Endoscopic detection of dysplasia in inflammatory bowel disease using time-gated laser-induced fluorescence spectroscopy

Time gated fluorescence spectroscopy in Barrett's oesophagus

“…[18][19][20][21][22][23] The aim of our study, therefore, was to examine, whether it is possible to endoscopically locate LGD or HGD in Barrett's oesophagus and to distinguish columnar lined oesophagus with SIM from columnar lined oesophagus without SIM, especially in short Barrett's. In contrast with previous investigations 13 we administered 5-aminolaevulinic acid (5-ALA) [24][25][26] to stimulate the metabolic production of protoporphyrin IX (PpIX) particularly in neoplastic tissue. Furthermore, we used a tuneable, pulsed solid state laser system to record immediate and delayed fluorescence spectra online, simultaneously with white light endoscopy.…”