Endoscopic Endonasal Transsphenoidal Surgery for Pituitary Adenomas

Pınar, Ercan; Yüceer, Nurullah; İmre, Abdülkadir; Güvenç, Gönül; Gündoğan, Onur

doi:10.1097/scs.0000000000001240

Cited by 27 publications

(14 citation statements)

References 20 publications

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“…To date, endoscopic pituitary cerebrospinal fluid leak rates have not been shown to be significantly different from microscopic leak rates (12.8% vs 12.2%, respectively) . Published reports estimate endoscopic leak rates fall somewhere in a range between 0.5% and 14% ,,. Our postoperative CSF leak rate of 5.5% is within this range.…”

Section: Discussionmentioning

confidence: 42%

Multi‐institutional study of risk factors for perioperative morbidity following transnasal endoscopic pituitary adenoma surgery

Boling

Karnezis

Baker

et al. 2015

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 42%

Multi‐institutional study of risk factors for perioperative morbidity following transnasal endoscopic pituitary adenoma surgery

Boling

Karnezis

Baker

et al. 2015

Int Forum Allergy Rhinol

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“…Pituitary adenoma (PA), among the most commonly encountered sellar pathologies, accounts for 10% of primary intracranial tumors. 1 Transsphenoidal surgery (TSS) became the preferred treatment for most adenomas in the 1960s. Over the last two decades, many surgeons have shifted from the microscope to the endoscope for TSS 2,3 in the hope that its superior visualization would result in fewer complications.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous series have reported the frequencies of various complications of endoscopic TSS. 1,2,[4][5][6][7] The reported incidence of postoperative diabetes insipidus (DI) is highly variable, ranging from 0.3 to 45%, [8][9][10][11][12][13][14][15][16][17][18] perhaps reflecting inconsistent definition, varying interval of follow-up, and diverse sellar pathologies.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Insipidus following Endoscopic Transsphenoidal Surgery for Pituitary Adenoma

et al. 2017

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Pituitary adenoma (PA), among the most commonly encountered sellar pathologies, accounts for 10% of primary intracranial tumors. The reported incidence of postoperative diabetes insipidus (DI) is highly variable. In this study, we report our experience with DI following endoscopic transsphenoidal surgery (TSS) for PAs, elucidating the risk factors of postoperative DI, the likelihood of long-term DI, and the impact of DI on the length of stay (LOS). The study included 178 patients who underwent endoscopic resection of PAs. Early DI was defined as that occurring within the first postoperative week. The mean follow-up was 36 months. Long-term DI was considered as DI apparent in the last follow-up visit. Of the 178 patients included in the study, 77% of the tumors were macroadenomas. Forty-seven patients (26%) developed early DI. Long-term DI was observed in 18 (10.1%) of the full cohort. Age younger than 50 years was significantly associated with a higher incidence of long-term DI ( = 0.02). Macroadenoma and gross total resection were significantly associated with higher incidence of early DI ( = 0.05 and = 0.04, respectively). The mean LOS was 4 days for patients with early postoperative DI and 3 days for those without it. The reported incidence of postoperative DI is significantly variable. We identified age younger than 50 years a risk factor for developing long-term postoperative DI. Gross total surgical resection and tumor size (> 1 cm) were associated with development of early DI. Early DI increased the LOS on average by 1 day.

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“…Gonadotropin secreting macroadenomas are also treated with surgical resection and subsequent radiation, but medical therapy such as bromocriptine or octreotide are only administered to patients who deny surgery or radiation. Thyrotropin secreting macroadenomas respond well to octreotide after surgery and radiation and thus can be a useful adjuvant therapy [13][14][15][16].…”

Section: Treatment For Pituitary Adenomasmentioning

confidence: 99%

Neoplasms of Central Nervous System: A Diagnostic Approach

Shan¹,

Zhong²,

Hu³

et al. 2018

Neoplasm

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Neoplasms of central nervous system accounts for approximately 1% of tumors of the human body, and they can be primary or secondary (metastatic), benign or malignant, and intra-axial or extra-axial. This chapter includes some most common brain and spinal cord tumors, like pituitary adenomas, meningiomas and gliomas, with their clinical, imaging, and histological characteristics for the diagnosis purpose, with additional treatment options and prognosis.

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Endoscopic Endonasal Transsphenoidal Surgery for Pituitary Adenomas

Abstract: Endoscopic transsphenoidal surgery is an effective and safe treatment for most patients with pituitary adenoma and could be considered the first-choice therapy in these patients.

Cited by 27 publications

References 20 publications

Multi‐institutional study of risk factors for perioperative morbidity following transnasal endoscopic pituitary adenoma surgery

Multi‐institutional study of risk factors for perioperative morbidity following transnasal endoscopic pituitary adenoma surgery

Diabetes Insipidus following Endoscopic Transsphenoidal Surgery for Pituitary Adenoma

Neoplasms of Central Nervous System: A Diagnostic Approach

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