Endoscopic Finding of a Large Vanishing Tumor

Fujisawa, Kimihiko; Matsumoto, Takayuki; Yoshimura, Ryoichi; Ayabe, Seiji; Tominaga, Mitsuhiro

doi:10.1055/s-2001-16517

Cited by 11 publications

(7 citation statements)

References 1 publication

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“…33 Anisakis-induced granulomas have been mistaken for tumours in the past, but gradually disappear in most patients, leading to the term "vanishing tumours". 8,42 In some patients, the inflammation takes longer to resolve, resulting in symptoms of chronic anisakiasis. It has been suggested that invasion of bacteria into the lesions formed around larval remains could exacerbate and prolong the ulceration.…”

Section: Immune Pathology In Anisakiasismentioning

confidence: 99%

“…Dead Anisakis larvae are not easily degradable; therefore, they are typical of stimuli that incite a granulomatous response . Anisakis ‐induced granulomas have been mistaken for tumours in the past, but gradually disappear in most patients, leading to the term “vanishing tumours” . In some patients, the inflammation takes longer to resolve, resulting in symptoms of chronic anisakiasis.…”

Section: Introductionmentioning

confidence: 99%

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Anisakis – immunology of a foodborne parasitosis

Nieuwenhuizen

2016

Parasite Immunology

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SummaryAnisakis species are marine nematodes which can cause zoonotic infection in humans if consumed in raw, pickled or undercooked fish and seafood. Infection with Anisakis is associated with abdominal pain, nausea and diarrhoea and can lead to massive infiltration of eosinophils and formation of granulomas in the gastrointestinal tract if the larvae are not removed. Re-infection leads to systemic allergic reactions such as urticarial or anaphylaxis in some individuals, making Anisakis an important source of hidden allergens in seafood. This review summarizes the immunopathology associated with Anisakis infection. Anisakiasis and gastroallergic reactions can be prevented by consuming only fish that has been frozen to −20°C to the core for at least 24 hours before preparation. Sensitization to

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Section: Immune Pathology In Anisakiasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anisakis – immunology of a foodborne parasitosis

Nieuwenhuizen

2016

Parasite Immunology

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“…When the larva of Anisakis dies after penetrating the mucosa, eosinophil infiltration, and proliferation of the connective tissue occur around the larval body, followed by formation of an eosinophilic granuloma, which has the appearance of a submucosal tumor. Subsequently, the granuloma usually decreases in size and gradually disappears 3,9,10. In this case, eosinophilia was absent but eosinophil infiltration was observed.…”

Section: Discussionmentioning

confidence: 68%

“…Besides directly visualizing worms penetrating into the gastric mucosa, endoscopy may reveal erythema, edema, erosive, hemorrhagic gastritis, tumor, or ulceration 6,10,11…”

Section: Discussionmentioning

confidence: 99%

A Case of Anisakiasis Invading the Stomach and the Colon at the Same Time after Eating Anchovies

et al. 2013

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Anisakiasis of the gastrointestinal tract is caused by the ingestion of raw fish or uncooked food infested with Anisakis larvae. A large number of cases of gastric anisakiasis have been reported in countries where the eating of raw fish is customary. However, there have been few reports of anisakiasis of the colon confirmed by colonoscopy and also very few reports of endoscopic ultrasonographic findings of anisakiasis. A 47-year-old man had epigastric pain with nausea after eating raw anchovies. Endoscopy found a living tubular structure penetrating into the lesser curvature of the stomach and the midtranseverse colon area. It was withdrawn with biopsy forceps. We report a case of anisakiasis simultaneously invading the stomach and the colon confirmed by endosopic utrasonographic findings and biopsy findings.

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“…Although the infection regresses gradually, it is sometimes misdiagnosed as a gastric ulcer or gastric cancer [ 14 , 15 ]. Chronic anisakiasis infection is often difficult to diagnose because its symptoms are mild and nonspecific and the larvae are denaturalized and absorbed in the submucosal layer [ 16 ]. The diagnosis is often made incidentally during an endoscopy or after the discovery of a mass in the abdomen [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Endosonographic Findings and the Natural Course of Chronic Gastric Anisakiasis: A Single-Center Experience

Park

Baek

Kim

et al. 2018

Gastroenterology Research and Practice

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Background Chronic gastric anisakiasis is a rare, usually asymptomatic, and difficult to diagnose infection incidentally discovered during endoscopy, resembling a subepithelial tumor (SET). Because its endoscopic ultrasonography (EUS) findings are not established, it is occasionally misdiagnosed as gastrointestinal mesenchymal tumors and removed by endoscopic or surgical resection. We aimed to assess the characteristic EUS findings of chronic gastric anisakiasis and the clinical course during follow-up. Methods The database of all patients who underwent EUS at Pusan National University Hospital (Busan, Korea) between January 2011 and December 2016 was retrospectively analyzed. A total of 28 SET cases with EUS features suggesting chronic gastric anisakiasis were included in the study. The EUS, histopathologic, and follow-up endoscopic features were analyzed. Results On EUS, the lesions were mainly located in the submucosal and/or propria muscle layers. Twenty-seven lesions (27/28, 96%) showed hypoechoic echogenicity, and 22 lesions (22/28, 79%) were heterogeneous. Hyperechoic tubular structures suggesting denaturalized Anisakidae larvae were seen in 22 lesions (22/28, 79%). Endoscopic biopsies revealed significant eosinophil infiltration (≥30 per high-power field) in 12 lesions (12/21, 57%). During the median follow-up period of 9 months (range, 1–55 months), SETs decreased or subsided in 26 lesions (26/28, 93%) with no change in the size of the two lesions (2/28, 7%). Conclusions Chronic gastric anisakiasis, although rare, should be included in the differential diagnoses for gastric SETs, especially in regions where raw fish is widely consumed. EUS findings suggesting chronic gastric anisakiasis are heterogeneously hypoechoic lesions with hyperechoic tubular structures, mainly in the submucosal and/or muscularis propria layers. Because chronic gastric anisakiasis decreases or subsides in most cases, follow-up endoscopy 6–12 months later is recommended.

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Endoscopic Finding of a Large Vanishing Tumor

Cited by 11 publications

References 1 publication

Anisakis – immunology of a foodborne parasitosis

Anisakis – immunology of a foodborne parasitosis

A Case of Anisakiasis Invading the Stomach and the Colon at the Same Time after Eating Anchovies

Endosonographic Findings and the Natural Course of Chronic Gastric Anisakiasis: A Single-Center Experience

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