Endoscopic Hemostasis in Nonvariceal Bleeding: An Overview

Mierop, F Van de; Fleischer, DE

doi:10.1055/s-2007-1005418

Cited by 12 publications

(3 citation statements)

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“…However, patients without a visible vessel in the ulcer crater have a much lower risk of further haemorrhage: oozing without other signs (10%), gray slough flat spots (7%) or a clean ulcer base (3%) [20]. Other factors which are prognostic for early recurrent haemorrhage include: patient age over 65 years, an admission haemoglobin !8 g/dl, clinical shock, haematemesis, recurrent bleeding, severe comorbidity or coagulopathies, an inhospital bleed, the need for transfusions of 15 red blood cell units (RBCU) in the first 24 h after admission or the need for emergency surgery [6,23,24]. Prognostic factors indicative of the failure of endoscopic treatment to control bleeding include: ulcer diameter 12 cm and shock on admission [25,26].…”

Section: Peptic Ulcersmentioning

confidence: 99%

Drug Therapy for Non-Variceal Upper Gastrointestinal Bleeding

Jenkins¹

1999

Digestion

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Section: Peptic Ulcersmentioning

confidence: 99%

Drug Therapy for Non-Variceal Upper Gastrointestinal Bleeding

Jenkins¹

1999

Digestion

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“…However, patients without a visible vessel in the ulcer crater have a much lower risk of further haemorrhage: oozing without other signs (10%), gray slough flat spots (7%) or a clean ulcer base (3%) [20]. Other factors which are prognostic for early recurrent haemorrhage include: patient age over 65 years; an admission haemoglobin !8 g/dl; clinical shock; haematemesis; recurrent bleeding; severe comorbidity or coagulopathies; an in-hospital bleed; the need for transfusions of 15 red blood cell units (RBCU) in the first 24 h after admission, or the need for emergency surgery [6,23,24]. Prognostic factors indicative of the failure of endoscopic treatment to control bleeding include: ulcer diameter 12 cm, and shock on admission [25,26].…”

Section: Peptic Ulcersmentioning

confidence: 99%

Somatostatin in the Treatment of Non-Variceal Upper Gastrointestinal Bleeding

Jenkins

Poulianos

Coraggio

et al. 1998

Dig Dis

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The efficacies of somatostatin and octreotide have been widely studied in the control of bleeding from oesophageal varices. It has also been suggested that these drugs may be useful for the control of non-variceal upper gastrointestinal (UGI) bleeding, including that from peptic ulcers. In approximately 80% of patients presenting with non-variceal UGI bleeding, haemorrhage ceases spontaneously and does not recur. However, the remaining 20% of patients require active treatment. Results from recent studies have indicated that somatostatin is an effective treatment for the control of non-variceal UGI bleeding in high-risk patients, i.e. those in whom haemorrhage does not cease spontaneously or is likely to recur. In contrast there is no good evidence available at present to support a role for octreotide in this indication. The efficacy of somatostatin in controlling bleeding in patients with non-variceal UGI bleeding at high risk of mortality upon admission, or rebleeding following endoscopy, coupled with an excellent safety and tolerability profile, suggests that it may be a valuable therapeutic option in the management of non-variceal bleeding.

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“…Injection therapy of bleeding peptic ulcers is an attractive endoscopic treatment modality because it is widely available, easy to perform, the equipment is cheap, and the intervention is effective and safe [1]. It has been shown that repeated endoscopic injection of fibrin glue is more effective than a single injection of polidocanol in the treatment of bleeding peptic ulcer [2].…”

Section: Introductionmentioning

confidence: 99%

Factor V Inhibitor after Injection of Human Thrombin (Tissucol) into a Bleeding Peptic Ulcer

Caers¹,

Reekmans

Jochmans

et al. 2003

Endoscopy

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Endoscopic injection of fibrin glue into a bleeding peptic ulcer is an effective and safe treatment modality. The present report describes a patient who developed rectal bleeding from an arteriovenous malformation after endoscopic injection of fibrin glue containing human thrombin into a gastric ulcer. Additional laboratory investigations revealed the presence of an inhibitor against coagulation factor V, which resulted in severe coagulopathy, triggering the bleeding. Acquired factor V inhibitors have frequently been reported with the use of bovine thrombin, but to our knowledge, they have never been documented in patients exposed to human thrombin. Endoscopists should be aware of this rare, but potentially serious, complication.

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Endoscopic Hemostasis in Nonvariceal Bleeding: An Overview

Cited by 12 publications

References 0 publications

Drug Therapy for Non-Variceal Upper Gastrointestinal Bleeding

Drug Therapy for Non-Variceal Upper Gastrointestinal Bleeding

Somatostatin in the Treatment of Non-Variceal Upper Gastrointestinal Bleeding

Factor V Inhibitor after Injection of Human Thrombin (Tissucol) into a Bleeding Peptic Ulcer

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