Endoscopic Hemostasis Using N-Butyl-2-Cyanoacrylate for Massive Gastric Bleeding During Endoscopic Transgastric Drainage of a Pancreatic Pseudocyst

Kim, Young Jee; Moon, Jong Ho; Ko, Bong Min; Lee, Jong Chan; Min, Seul Ki; Yoo, Hee Yong; Lee, Moon Sung

doi:10.1111/j.1443-1661.2010.01096.x

Cited by 1 publication

(1 citation statement)

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“…Some of them have, moreover, a huge impact in the medicine field. n -Butyl cyanoacrylate (BCA) is one of the most successfully used tissue adhesives [2,3,4,5,6], because it provides great tension resistance with bacteriostatic and haemostatic characteristics [7,8]. It is also used as precursor for nanoparticle preparations for controlled delivery of drugs [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

n-Butyl Cyanoacrylate Synthesis. A New Quality Step Using Microwaves

et al. 2014

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Alkyl cyanoacrylates are interesting products for use in industry because of their properties enabling them to stick together a wide range of substrates. n-Butyl cyanoacrylate is one of the most successfully used tissue adhesives in the field of medicine because it exhibits bacteriostatic and haemostatic characteristics, in addition to its adhesive properties. At present, its synthesis is performed with good yields via Knoevenagel condensation using conventional sources of heating, but this requires a long processing time. The aim of this work was to look for a new way of synthesising n-butyl cyanoacrylate using microwave irradiation as the source of heating. This non-conventional source of heating most likely reduces the process time of the synthesis. In comparison with a conventional heating source, such as an oil bath, the results showed the advantages of this method whereby the n-butyl cyanoacrylate gave the same yield and quality with a reduction in the reaction time by a factor of 3-5-fold.

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