Endoscopic injection sclerotherapy for esophageal varices in cirrhotic patients without hepatocellular carcinoma: a comparison of longterm survival between prophylactic therapy and emergency therapy

Ogusu, Tomofumi; Iwakiri, Ryuichi; Sakata, Hiroyuki; Matsunaga, Keiji; Shimoda, Ryo; Oda, Kayoko; Watanabe, Kei; Ootani, Hibiki; Kikkawa, Atsushi; Ootani, Akifumi; Tsunada, Seiji; Fujimoto, Kazuma

doi:10.1007/s005350300064

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Moreover, Ogusu et al . showed that prophylactic EIS might be more effective in prolonging long‐term survival of patients with liver cirrhosis in the absence of HCC than emergency EIS 9 . EIS is an effective therapy for esophageal varices and is less invasive than surgery.…”

Section: Discussionmentioning

confidence: 99%

“…8 Moreover, Ogusu et al showed that prophylactic EIS might be more effective in prolonging long-term survival of patients with liver cirrhosis in the absence of HCC than emergency EIS. 9 EIS is an effective therapy for esophageal varices and is less invasive than surgery. However, EIS is associated with several complications, such as pleural effusion, pulmonary failure, renal failure, and esophageal stricture.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Gastric Ulcer After Endoscopic Injection Sclerotherapy for Esophageal Varices

Sato

Yamazaki

Toyota

et al. 2006

Digestive Endoscopy

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Background: Endoscopic injection sclerotherapy (EIS) is an effective procedure for the treatment of esophageal varices. In the present study, the pathogenesis of gastric ulcer after EIS for esophageal varices was investigated. Methods: EIS for esophageal varices was performed for 610 patients in our department, and the frequency and clinical course of gastric ulcer after EIS were investigated retrospectively. EIS was performed using 5% ethanolamine oleate with iopamidol, which was injected intermittently under fluoroscopy. Results: Gastric ulcer after EIS for esophageal varices was observed in 14 of the 610 (2.3%) patients. These were located around the cardia of the stomach from the fornix to the gastric body. Gastric ulcer extended from the stomach lining into the esophagus in 11 of the 14 cases. Severe chest pain was observed, and dark purple mucosal changes of the esophagus and stomach were detected endoscopically at the time of injection in all 14 cases. All cases received dripping therapy, and prescription of a proton pump inhibitor. Gastric ulcer after EIS was refractory, and almost 2 months was required until the healing stage was reached. Conclusion: Gastric ulcer after EIS for esophageal varices is a rare but important complication of EIS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Gastric Ulcer After Endoscopic Injection Sclerotherapy for Esophageal Varices

Sato

Yamazaki

Toyota

et al. 2006

Digestive Endoscopy

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“…Primary prophylaxis with pharmacological agents or endoscopic treatment has been adopted to reduce mortality associated with variceal bleeding [6–8]. However, treatment with beta blockers and/or endoscopic band ligation is useful for the primary prophylaxis of variceal bleeding only in some patients with high-risk EV [1, 8–10]. Therefore, endoscopic screening is required to detect high-risk EV in patients with liver cirrhosis so that appropriate prophylactic treatment can be initiated [8, 10].…”

Section: Introductionmentioning

confidence: 99%

Esophageal Capsule Endoscopy for Screening Esophageal Varices among Japanese Patients with Liver Cirrhosis

Ishiguro

Saito

Imazu

et al. 2012

Gastroenterology Research and Practice

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Purpose. Although esophageal capsule endoscopy (ECE) is reportedly useful in the diagnosis of esophageal varices (EV), few reports have described the benefits of this technique in Asian countries. The present paper evaluates the usefulness of ECE for diagnosing EV in Japanese patients with cirrhosis. Methods. We examined 29 patients with cirrhosis (20 males and 9 females; mean age 60 years; Child-Pugh classification A/B/C; 14/14/1) using ECE followed by esophagogastroduodenoscopy (EGD). High-risk EV were defined as F2 and/or RC2 and above. Results. The sensitivity and specificity of ECE for the diagnosis of high-risk EV were 92% and 80%, respectively. Conclusions. The findings showed that ECE is a highly sensitive method of diagnosing high-risk EV that requires endoscopic or pharmacological therapy. Thus, ECE might be a useful method for the screening and followup of EV in patients with cirrhosis.

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Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

Gattini

Cifuentes

Torres‐Robles

et al. 2020

Cochrane Database of Systematic Reviews

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Endoscopic injection sclerotherapy for esophageal varices in cirrhotic patients without hepatocellular carcinoma: a comparison of longterm survival between prophylactic therapy and emergency therapy

Abstract: Prophylactic sclerotherapy for esophageal varices might be more effective in prolonging longterm survival of patients complicated by liver cirrhosis in the absence of hepatocellular carcinoma, compared with emergency sclerotherapy.

Cited by 7 publications

References 20 publications

Evaluation of Gastric Ulcer After Endoscopic Injection Sclerotherapy for Esophageal Varices

Evaluation of Gastric Ulcer After Endoscopic Injection Sclerotherapy for Esophageal Varices

Esophageal Capsule Endoscopy for Screening Esophageal Varices among Japanese Patients with Liver Cirrhosis

Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

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