Endoscopic Kyoto classification of <i>Helicobacter pylori</i> infection and gastric cancer risk diagnosis

Toyoshima, Osamu; Nishizawa, Toshihiro; Koike, Kazuhiko

doi:10.3748/wjg.v26.i5.466

Cited by 95 publications

(98 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2b, ▶ Fig. 2c) [13][14][15]. Penthorum chinense Pursh, a rooted vascular plant distributed in eastern Asia, is frequently found in the muddy wetland, riparian food plains and fallow paddy fields in Japan and resembles the feet of octopus.…”

Section: Nodularitymentioning

confidence: 99%

Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders

et al. 2020

View full text Add to dashboard Cite

Background and study aims Eosinophilic gastrointestinal disorders are classified into eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis according to the site of eosinophilic infiltration. Although well established in eosinophilic esophagitis, endoscopic findings in eosinophilic gastritis and eosinophilic gastroenteritis with regard to gastric lesions have not been clearly described. The aim of this study was to identify endoscopic findings of gastric lesions associated with eosinophilic gastrointestinal disorders. Patients and methods Out of 278 patients with eosinophilic gastrointestinal disorders, 18 had eosinophilic gastritis or eosinophilic gastroenteritis confirmed by biopsy; their endoscopic images were analyzed retrospectively. The association between endoscopic findings and number of eosinophils in the gastric mucosa was investigated. Results Erythema was most frequently observed (72 %), followed by ulcers (39 %), discoloration (33 %), erosions (28 %), nodularity (28 %), and polyps (28 %). There were several unique endoscopic findings such as submucosal tumor-like deep large ulcers in three patients, antral Penthorum-like appearances (small nodules radially lined toward the pyloric ring) in three patients, “muskmelon-like appearances” (discolored mucosa-composed mesh pattern) in three patients, multiple white granular elevations in two patients, cracks (appearance of furrows similar to those in eosinophilic esophagitis) in five patients, and antral rings in one patient. No significant association was observed between endoscopic findings and number of gastric eosinophils. Conclusions Several unique endoscopic findings of gastric lesions were observed in patients with eosinophilic gastritis or eosinophilic gastroenteritis. Submucosal tumor-like ulcers, antral Penthorum-like appearances, muskmelon-like appearances, and cracks might be associated with eosinophilic gastrointestinal disorders.

show abstract

Section: Nodularitymentioning

confidence: 99%

Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[16][17][18] Endoscopy is essential to diagnose gastritis, evaluate the presence or absence of H. pylori infection, and assess the risk of gastric cancer. [19][20][21] The Kyoto classification of gastritis is an endoscopy-based classification proposed by the Japan Gastroenterological Endoscopy Society in 2013. It was introduced to estimate the risk of H. pylori infection and gastric cancer on endoscopy.…”

Section: Introductionmentioning

confidence: 99%

“…A high score indicates an increased risk of gastric cancer and H. pylori infection. 20 Endoscopic atrophy was classified according to the extent of mucosal atrophy, as described by Kimura and Takemoto. [29][30][31] Nonatrophy and C-I were scored as atrophy score 0, C-II and C-III as atrophy score 1, and O-I to O-III as atrophy score 2.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylorieradication improved the Kyoto classification score on endoscopy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background and Aim: Endoscopy-based Kyoto classification predicts the risk of Helicobacter pylori infection and gastric cancer; however, the change in score following H. pylori eradication remains unknown. We retrospectively compared the Kyoto score before and after H. pylori eradication. Methods: H. pylori-positive patients who underwent baseline esophagogastroduodenoscopy (EGD), successful H. pylori eradication, and surveillance EGD were enrolled. The Kyoto score is a sum of scores for atrophy (Kimura-Takemoto atrophicborder classification none or C1: 0, C-II or C-III: 1

show abstract

“…Endoscopic Kyoto classification score for gastritis, from 0 to 8, is based on the total scores of the following five endoscopic findings: Atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. A high score represents increased risk for gastric cancer and H. pylori infection[ 12 ].…”

Section: Methodsmentioning

confidence: 99%

“…The Kyoto classification was established with the aim to unify the endoscopic diagnosis of gastritis in daily practice and match it with the histological diagnosis. The Kyoto classification score consisted of scores in gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness[ 12 ]. Several studies have revealed the association of the Kyoto score with H. pylori infection[ 13 - 17 ] and gastric cancer risk[ 18 - 20 ]; however, the consistency of the Kyoto score with pathological findings has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity

Toyoshima¹,

Nishizawa²,

Yoshida³

et al. 2020

WJG

Self Cite

View full text Add to dashboard Cite

BACKGROUND Endoscopy-based Kyoto classification for gastritis and pathological topographic distribution of neutrophil infiltration are correlated with gastric cancer risk. AIM To investigate the association between Kyoto classification and the topographic distribution of neutrophil activity. METHODS Kyoto classification score, ranging from 0 to 8, consisted of atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. Neutrophil activity was scored according to the updated Sydney System using biopsy samples obtained from the greater curvature of the corpus and the antrum. The participants were divided into four categories, inactive stomach, antrum-predominant gastritis, pangastritis, and corpus-predominant gastritis, based on the topographic distribution of neutrophil activity. Effects of sex, age, body mass index, drinking habit, smoking habit, family history of gastric cancer, serum Helicobacter pylori ( H. pylori ) antibody, and Kyoto score on topography of neutrophil infiltration were analyzed. RESULTS A total of 327 patients (comprising 50.7% women, with an average age of 50.2 years) were enrolled in this study. H. pylori infection rate was 82.9% with a mean Kyoto score of 4.63. The Kyoto score was associated with the topographic distribution of neutrophil activity. Kyoto scores were significantly higher in the order of inactive stomach, antrum-predominant gastritis, pangastritis, and corpus-predominant gastritis (3.05, 4.57, 5.21, and 5.96, respectively). Each individual score of endoscopic findings ( i.e ., atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness) was correlated with the topographic distribution of neutrophil activity. On multivariate analysis, the Kyoto score, age, and serum H. pylori antibody were independently associated with the topographic distribution of neutrophil activity. CONCLUSION The Kyoto classification score was associated with the topographic distribution of neutrophil activity.

show abstract

Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis

Cited by 95 publications

References 86 publications

Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders

Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders

Helicobacter pylorieradication improved the Kyoto classification score on endoscopy

Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity

Contact Info

Product

Resources

About