Endoscopic Mucosal Resection of an Epstein–Barr Virus-Associated Lymphoepithelioma-Like Gastric Carcinoma

Tang, Shou‐jiang; Ahmed, Naveed; Bhaijee, Feriyl; Sheehan, John F.; Subramony, Charu; Jackson, Courtney; Lewin, Jack R.

doi:10.1007/s10620-012-2223-3

Cited by 9 publications

(6 citation statements)

References 5 publications

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“…Shin et al reported the clinicopathological features of 70 early GCLS patients and showed an extremely low rate of LNM, as well as the tendency for the macroscopic type, tumor location, and tumor size [30]. With its low likelihood of LNM, endoscopic resection has been suggested as an alternative treatment option for early GCLS patients [17][18][19]. However, despite the favorable prognosis of early GCLS, it remains unclear whether AGCLS also shows a favorable prognosis and similar clinicopathological features.…”

Section: Discussionmentioning

confidence: 99%

“…There have been several reports demonstrating the favorable prognosis of GCLS compared with other gastric adenocarcinomas, as well as its differentiating clinicopathological features [11][12][13][14][15][16]. With its low frequency of lymph node metastasis (LNM), an expanded indication of endoscopic resection in early GCLS cases has been suggested [17][18][19][20]. However, to our knowledge, current information on GCLS including its clinicopathological features, survival outcomes, and treatment remains inadequate with only a few studies owing to its rarity [13].…”

Section: Introductionmentioning

confidence: 99%

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Postoperative outcomes of gastric carcinoma with lymphoid stroma

et al. 2020

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Background: Gastric carcinoma with lymphoid stroma (GCLS) is a rare subtype of gastric cancer. There have been several reports demonstrating the favorable prognosis of early GCLS without lymph node metastasis (LNM) compared with gastric adenocarcinomas. However, it remains unknown whether advanced GCLS (AGCLS) with LNM has a similar prognosis and clinicopathological features. This study aimed to assess the clinicopathological features of GCLS of all stages. Methods: We retrospectively assessed 375 patients who were pathologically diagnosed with gastric cancer and underwent curative surgical resection at Tokyo Medical University, Japan, between September 2013 and October 2019. Of these patients, 357 (95.2%) patients were pathologically diagnosed with gastric adenocarcinomas, and 18 (4.8%) patients were diagnosed with GCLS. The GCLS patients (n = 18) were compared with the gastric adenocarcinoma patients (non-GCLS patients, control) (n = 357) in terms of their clinicopathological features and clinical outcome. Results: The GCLS patients showed significantly predominant upper gastric locations (P = 0.003), lower number of LNM (P = 0.01), and better overall survival rate than the non-GCLS patients (P = 0.029). The predominant upper gastric locations (P = 0.0002), lower number of LNM (P = 0.003), and better overall survival rate (P = 0.04) were significantly correlated in the AGCLS with LNM patients compared with the advanced non-GCLS with LNM patients. For survival analyses, surgical procedure, tumor location, and numbers of positive LNM were adjusted by 1:1 propensity score matching. After adjustment, the overall survival rate was significantly higher in the AGCLS group than in the advanced non-GCLS group (P = 0.03). Conclusion: AGCLS has distinct clinicopathological features and clinical behavior that are similar to those of early GCLS. AGCLS with LNM patients showed a significantly lower number of LNM and a better survival rate than advanced non-GCLS with LNM patients. To our knowledge, this study is the first report to describe the clinicopathological features of AGCLS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Postoperative outcomes of gastric carcinoma with lymphoid stroma

et al. 2020

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“…There are several previous case reports that describe gastric LELC as a submucosal mass on macroscopic observation, endoscopy or other imaging modalities, such as endoscopic ultrasound or CT [5][6][7][8][9]. However, at our institution, we have observed several gastric LELCs that show various morphological distributions, including submucosal mass-like lesions with features that overlap with other gastric submucosal tumours.…”

Section: Introductionmentioning

confidence: 60%

“…In that study, it was reported that the expansive growth of tumour cells with lymphoid infiltration enabled them to be recognized as submucosal nodules, and they also proposed that EBV-associated EGC might form nodules after invading the submucosal layer. Other studies and case reports with endoscopic and pathological evaluations of EBVassociated gastric carcinoma reported submucosal nodules with lymphocytic infiltration [6,[15][16][17][18]. In addition, all of the reported tumours presented as submucosal tumours, except for two lesions which were classified as EGC.…”

Section: Discussionmentioning

confidence: 82%

Computed tomography findings for a gastric lymphoepithelioma-like carcinoma: How often does it present as a submucosal mass?

Kim

Son

et al. 2015

Eur Radiol

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“…The patients with this variant tumor can be good candidates for EMR in regard to a lower frequency of lymph node metastasis and a relative well circumscribed tumor margin that can be easily assessed endoscopically. Some clinical trials to remove EBVassociated LELCS in an early stage have been reported using an endoscopic resection such as EMR or submucosal dissection [36,37]. The patients treated with endoscopic resection have shown a benign clinical course without recurrence or metastasis.…”

Section: Introductionmentioning

confidence: 99%

Variants of Gastric Carcinoma: Morphologic and Theranostic Importance

Lee¹,

Kim²,

Ro³

2013

Gastric Carcinoma- New Insights Into Current Management

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Endoscopic Mucosal Resection of an Epstein–Barr Virus-Associated Lymphoepithelioma-Like Gastric Carcinoma

Cited by 9 publications

References 5 publications

Postoperative outcomes of gastric carcinoma with lymphoid stroma

Postoperative outcomes of gastric carcinoma with lymphoid stroma

Computed tomography findings for a gastric lymphoepithelioma-like carcinoma: How often does it present as a submucosal mass?

Variants of Gastric Carcinoma: Morphologic and Theranostic Importance

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