Endoscopic optical coherence tomography based on a microelectromechanical mirror

Pan, Yingtian; Xie, Huikai; Fedder, Gary K.

doi:10.1364/ol.26.001966

Cited by 257 publications

(127 citation statements)

References 13 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…Distal-actuated catheters are based on either miniaturized actuators [39][40][41] or microelectromechanical systems (MEMS) technology [42][43][44][45][46][47][48][49]. These catheters generally can scan in 2D for 3D imaging and can scan at high speeds.…”

Section: Introductionmentioning

confidence: 99%

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Kim¹,

Park²,

Maguluri³

et al. 2007

Opt. Express

158

111

View full text Add to dashboard Cite

A two-axis scanning catheter was developed for 3D endoscopic imaging with spectral domain optical coherence tomography (SD-OCT). The catheter incorporates a micro-mirror scanner implemented with microelectromechanical systems (MEMS) technology: the micro-mirror is mounted on a two-axis gimbal comprised of folded flexure hinges and is actuated by magnetic field. The scanner can run either statically in both axes or at the resonant frequency (>= 350Hz) for the fast axis. The assembled catheter has an outer diameter of 2.8 mm and a rigid part of 12 mm in length. Its scanning range is ± 20˚ in optical angle in both axes with low voltages (1~3V), resulting in a scannable length of approximately 1 mm at the surface in both axes, even with the small catheter size. The catheter was incorporated with a multi-functional SD-OCT system for 3D endoscopic imaging. Both intensity and polarization-sensitive images could be acquired simultaneously at 18.5K axial scans/s. In vivo 3D images of human fingertips and oral cavity tissue are presented as a demonstration. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996). 26. B. E. Bouma and G. J. Tearney, "Power-efficient nonreciprocal interferometer and linear-scanning fiberoptic catheter for optical coherence tomography," Opt. Lett. 24, 531-533 (1999).

show abstract

Section: Introductionmentioning

confidence: 99%

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Kim¹,

Park²,

Maguluri³

et al. 2007

Opt. Express

158

111

View full text Add to dashboard Cite

show abstract

“…First, the scanning MEMS mirrors are operated by using electrostatic [25][26][27][28][29][30][31], electromagnetic [22,32], or electrothermal [33][34][35][36][37][38][39] actuation. An electrostatic force between suspending and fixed electrodes induces the electrostatic actuation, which allows a high scanning resonant frequency but it often requires high operational voltages.…”

Section: Actuation Mechanism Of Microscannersmentioning

confidence: 99%

“…In particular, a simple configuration of a bimorph cantilever substantially increases the fill factor of a mirror plate. Pan et al have reported an early model of a 1D electrothermal MEMS mirror [34]. The MEMS mirror is actuated by the bimorph structure composed of Al and SiO 2 .…”

Section: Actuation Mechanism Of Microscannersmentioning

confidence: 99%

Microscanners for optical endomicroscopic applications

Hwang

Seo

Jeong

2017

Micro and Nano Syst Lett

View full text Add to dashboard Cite

MEMS laser scanning enables the miniaturization of endoscopic catheters for advanced endomicroscopy such as confocal microscopy, multiphoton microscopy, optical coherence tomography, and many other laser scanning microscopy. These advanced biomedical imaging modalities open a great potential for in vivo optical biopsy without surgical excision. They have huge capabilities for detecting on-demand early stage cancer with non-invasiveness. In this article, the scanning arrangement, trajectory, and actuation mechanism of endoscopic microscanners and their endomicroscopic applications will be overviewed.

show abstract

“…OCT has been extended to perform Doppler imaging of blood flow and birefringence imaging to investigate laser intervention [29][30][31]. Imaging delivery systems have been engineered to enable OCT of external and internal tissues, including microscopes, hand-held probes, imaging needles, catheters, and endoscopes (Figure 2) [14,15,32,33]. Most recently, OCT has been combined with endoscope-based delivery to perform in vivo imaging in human patients [12,[34][35][36][37].…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Optical Coherence Tomography: Feasibility for Basic Research and Image-guided Surgery of Breast Cancer

Boppart

Luo

Marks

et al. 2004

Breast Cancer Res Treat

221

178

View full text Add to dashboard Cite

SummaryDiagnostic trends in medicine are being directed toward cellular and molecular processes, where treatment regimens are more amenable for cure. Optical imaging is capable of performing cellular and molecular imaging using the short wavelengths and spectroscopic properties of light. Diffuse optical tomography is an optical imaging technique that has been pursued as an alternative to X-ray mammography. While this technique permits noninvasive optical imaging of the whole breast, to date it is incapable of resolving features at the cellular level. Optical coherence tomography (OCT) is an emerging high-resolution biomedical imaging technology that for larger and undifferentiated cells can perform cellular-level imaging at the expense of imaging depth. OCT performs optical ranging in tissue and is analogous to ultrasound except reflections of near-infrared light are detected rather than sound. In this paper, an overview of the OCT technology is provided, followed by images demonstrating the feasibility of using OCT to image cellular features indicative of breast cancer. OCT images of a well-established carcinogen-induced rat mammary tumor model were acquired. Images from this common experimental model show strong correlation with corresponding histopathology. These results illustrate the potential of OCT for a wide range of basic research studies and for intra-operative image-guidance to identify foci of tumor cells within surgical margins during the surgical treatment of breast cancer.

show abstract

Endoscopic optical coherence tomography based on a microelectromechanical mirror

Cited by 257 publications

References 13 publications

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Microscanners for optical endomicroscopic applications

Optical Coherence Tomography: Feasibility for Basic Research and Image-guided Surgery of Breast Cancer

Contact Info

Product

Resources

About