Schistosoma proctocolitis is a rare disease entity, with limited literature on its occurrence. We report the case of a 17 year old male from an endemic area around Lake Victoria, Western Kenya, where detailed disease mapping of Schistosomiasis has been carried out. The patient presented with a seven year history of a protruding rectal mass and occasional hematochezia. Colonoscopy revealed multiple polyps involving the entire colon to the anus, and pathology showed inflammatory polyps secondary to Schistosoma