Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension

Fletcher, Aaron M.; Greenlee, Jeremy D.W.; Chang, Kristi; Smoker, Wendy R. K.; Kirby, Patricia; O’Brien, Erin

doi:10.1016/j.jocn.2011.11.016

Cited by 22 publications

(16 citation statements)

References 7 publications

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“…The frequent adjacent granulomatous and inflammatory reaction along with an indolent course and a generally good prognosis support a benign or reactive rather than neoplastic process . Of the 65 cases of CAPNON that we identified in the literature, only one case presented with two separate lesions diagnosed 8 years apart in the same individual . The remaining 64 cases were solitary.…”

Section: Introductionmentioning

confidence: 77%

“…This entity shows male predominance (1.92:1) but does not seem to have a predilection for an age group . Sixty‐five cases have been reported in the literature, 41 of which were intracranial and mostly intradural, 20 in the spinal canal and four at the craniovertebral junction . Of the 65 reported cases, 64 cases consisted of a solitary lesion, while only one case presented with one initial lesion and the second many years later …”

Section: Discussionmentioning

confidence: 99%

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Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Abdaljaleel

Mazumder

et al. 2016

Neuropathology

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We report a case of multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON) with associated multifocal perivascular microcalcifications and vascular calcinosis. Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a very rare condition that may arise in extra-axial and occasionally, in intra-axial locations. Moreover, it is nearly always a solitary mass with only one case with two lesions reported. While the etiology and pathogenesis of CAPNON remains unclear, the histopathology findings of this entity have been well described. We report a case of a 62-year-old woman with 18 calcifying radiologic lesions involving bilateral cerebral hemispheres. Histologically, these lesions have features similar to that reported for CAPNON, including nodular calcification with fibro-osseous components and peripheral histiocytic reaction. The patient had a poorly documented diagnosis of neurocyticercosis 32 years prior, although without tissue confirmation. The lack of detectable cysticercus serum antibody titers, and absence of residual larval or cyst wall tissue render multifocal calcific involution of that parasite unprovable although still plausible. We also raise the possibility of a blood-brain barrier derangement and/or a metabolic disorder as an alternative etiology. Whether this case of MCAPNON shares the same pathogenesis as the usual solitary CAPNON is unclear.

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Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Abdaljaleel

Mazumder

et al. 2016

Neuropathology

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“…The surviving patient was a woman who suffered from bilateral headaches and a calcified mass was seen near the right orbital roof on skull X‐ray. Since then, several authors have reported additional patients with calcified intracranial and spinal masses. The resected lesion has the classical appearance of CAPNON described in the literature with the chondromyxoid matrix, delicate stroma, radiating fibrillary striations and rimming by eccentric “epithelioid” cells .…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory changes, including foreign‐body reaction also are frequently seen. The cell of origin of this process is uncertain but arachnoidal cells or fibroblasts have been proposed . Most pathologists believe it is a reactive rather than neoplastic condition .…”

Section: Discussionmentioning

confidence: 99%

Multiple calcifying pseudoneoplasms of the neuraxis

et al. 2015

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Calcified pseudoneoplasms of the neuraxis (CAPNON) are a rare diagnostic entity. They have been reported intra-cranially as well as in the spine, and are most commonly found at the skull base. This is a case report of a 38-year-old woman who presented with bilateral CAPNON, diagnosed 8 years apart. While there are approximately 46 reported in the current literature of cerebral and spinal fibro-osseous lesions, this is the first report of separate lesions.

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“…Most of the lesions were safely removed via open craniotomy as in our case, but some cases have been reported to be resected endoscopically as in the case of a CAPNON of the anterior skull base 10. No additional chemotherapy or radiotherapy is needed due to the benign behaviour of this lesion.…”

Section: Discussionmentioning

confidence: 76%

Occipital calcified pseudoneoplasms of the neuraxis (CAPNON): understanding a rare pathology

et al. 2014

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SUMMARYCalcifying pseudoneoplasms of the neuraxis (CAPNON) are rare and typically benign lesions that can occur anywhere within the central nervous system. Aetiology of this lesion is unclear and surgical removal is usually curative. We present a 24-year-old male patient with a history of occipital migraines who was admitted after sudden onset seizure and loss of vision. CT and MRI demonstrated a small calcifying lesion in the right temporo-occipital lobe. The patient underwent gross total resection of the tumour mass and pathological analysis revealed a CAPNON. The preoperative diagnosis of CAPNON remains difficult due to unspecific radiological findings, yet a clear understanding of characteristic pathological findings and prognosis of CAPNON remains paramount. BACKGROUND

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Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension

Cited by 22 publications

References 7 publications

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Multiple calcifying pseudoneoplasms of the neuraxis

Occipital calcified pseudoneoplasms of the neuraxis (CAPNON): understanding a rare pathology

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