Endoscopic resection of early-stage SMAD4 juvenile polyposis does not prevent disease spreading in the stomach

Baldysiak, Etienne; Benech, Nicolas; Calavas, Laura; Rivory, Jérôme; Lavrut, Pierre-Marie; Saurin, Jean‐Christophe; Pioche, Mathieu

doi:10.1055/a-0978-6734

Cited by 1 publication

(2 citation statements)

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“…Although we diagnosed the present case as GJP, it might be better described as "JPS of the gastric predominant type," as the patient had three colonic pol- According to the National Comprehensive Cancer Network guideline (13), EGD is recommended every two to three years in patients with JPS. In contrast, total gastrectomy should be considered in patients with refractory anemia, hypoproteinemia, and coexisting GJP and gastric cancer, as GJP has a high malignant potential (4,14).…”

Section: Discussionmentioning

confidence: 99%

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Gastric Juvenile Polyposis with Intramucosal Cancer Diagnosed by Magnifying Endoscopy with Narrow-band Imaging

et al. 2023

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Although gastric juvenile polyposis (GJP) often coexists with gastric cancer, a preoperative accurate diagnosis is still difficult to obtain. A 70-year-old woman was referred for epigastralgia and anemia. Esophagogastroduodenoscopy with a conventional endoscope showed numerous gastric polyps with no cancerous findings. Magnifying endoscopy with narrow-band imaging (M-NBI) showed cancerous findings, and a target biopsy revealed adenocarcinoma. Histopathological findings after endoscopic resection confirmed a diagnosis of juvenile polyposis with intramucosal adenocarcinoma. Genetic analyses revealed a germline pathogenic variant of SMAD4. A target biopsy using M-NBI and endoscopic resection proved useful for confirming the preoperative diagnosis of coexisting cancerous lesions in GJP.

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Section: Discussionmentioning

confidence: 99%

“…According to the National Comprehensive Cancer Network guideline ( 13 ), EGD is recommended every two to three years in patients with JPS. In contrast, total gastrectomy should be considered in patients with refractory anemia, hypoproteinemia, and coexisting GJP and gastric cancer, as GJP has a high malignant potential ( 4 , 14 ).…”

Section: Discussionmentioning

confidence: 99%