“…The high accuracy and reliability of this novel registration device was proven by the measurement of values in the submillimetric range for target fiducials located in the lateral skull base region, which almost matched the accuracy of fixed bone-implanted marker registration. Although the more distant targets yielded slightly larger values, confirming the significant impact of the distance between the registration and target points on the accuracy [7,8,21], even the maximum deviation of 1.2 mm is still within the range (1 to 2 mm) that is often considered ''clinically acceptable'' for navigation system accuracy [1,21,25,26]. Maxillary splint-based systems with extraoral extensions for reference markers have been used previously with sufficient navigational accuracy in neurosurgery (0.29-0.86 mm [17], 0.0-2.0 mm [27]), in sinus surgery (1.56 AE 0.76 mm [28]), and in the temporal region (0.73 AE 0.25 mm [17,29]); however, only a few of these systems have been tested for targets in the lateral skull base region [15,29,30,31].…”