2017
DOI: 10.1016/j.gie.2016.09.023
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Endoscopic submucosal dissection for Barrett’s early neoplasia: a multicenter study in the United States

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Cited by 94 publications
(86 citation statements)
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“…EUS has been reported as unreliable in staging T2N0M0 cancers (19,20); therefore, for cT1N0M0 and cT2N0M0 cancers, additional information is needed for decision-making. For T1N0M0 cancers, endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are highly effective in confirming EUS cT1N0M0 and differentiating cT1a from cT1b (18,(21)(22)(23). Note that pathologically confirmed T1 by EMR remains cT1, not pT1 (24).…”
Section: Histologic Cell Typementioning
confidence: 99%
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“…EUS has been reported as unreliable in staging T2N0M0 cancers (19,20); therefore, for cT1N0M0 and cT2N0M0 cancers, additional information is needed for decision-making. For T1N0M0 cancers, endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are highly effective in confirming EUS cT1N0M0 and differentiating cT1a from cT1b (18,(21)(22)(23). Note that pathologically confirmed T1 by EMR remains cT1, not pT1 (24).…”
Section: Histologic Cell Typementioning
confidence: 99%
“…Tumors that are likely to demonstrate submucosal invasion are larger than 15 mm or poorly "lifting" (22). Similar to EMR specimens, the tissue orientation in ESD specimens facilitates the crucial distinction between pT1a and pT1b cancer (23).…”
Section: Handling Of Resection Specimenmentioning
confidence: 99%
“…Most early Barrett's neoplasia can be adequately treated by EMR to remove all visible abnormalities followed by eradication of the remaining flat Barrett's esophagus with radiofrequency ablation . Larger lesions (≥15 mm) usually require piecemeal EMR . Complete endoscopic resection (CER) of short‐segment Barrett's neoplasia including high‐grade dysplasia (HGD) or early adenocarcinoma, by 2–3 stage radical band mucosectomy is an effective, safe and durable treatment, with complete remission of neoplasia achieved in 98% of patients after mean follow up of 40 months .…”
Section: Role Of Esd: Comparing Outcomes For Early Gastrointestinal Tmentioning
confidence: 99%
“…Our results add to the evidence that supports the use of ESD for the treatment of Barrett's neoplasia . The nature of EMR limits the endoscopist's ability to accurately and consistently control the depth of resection and ESD has been suggested as an alternative that allows for better visualization of depth of both the lesion and resection plane . Unfortunately, direct comparisons between ESD and EMR for the treatment of Barrett's neoplasia are limited to relatively small studies or extrapolations from treatment of superficial squamous cell carcinoma of the esophagus .…”
Section: Discussionmentioning
confidence: 73%