Endoscopic treatment of early oesophageal or gastric cancer.

“…Dr. Furukawa, of the Osaka Medical Center for Cancer and Cardiovascular Disease, introduced a report from the Osaka cancer population-based registry showing a declining trend in reported gastric cancer mortality, but indicating that the morbidity of gastric cancer is still the highest among other cancers [9]. Nevertheless, in recent years, since the development of EMR, surgical resections for early gastric cancer are declining [3]. It should be noted that EMR patients will be included in the results for treatment of gastric cancer in future statistics.…”

Section: Total Number Of Gastric Cancer Patients Treated Surgicallymentioning

confidence: 99%

“…The proportion of patients with early gastric cancer has increased steadily, from approximately 20% in the 1970s to 50% in the 1990s [1]. Endoscopic mucosal resection (EMR) and limited surgery are commonly employed for patients with early gastric cancer [3], while, D2 or more extensive lymph node dissection has commonly been employed safely the treatment results at each institution, the 5-year survival rates, determined by the Kaplan-Meier method, were employed.…”

Section: Introductionmentioning

confidence: 99%

State of the art in the treatment of gastric cancer: from the 71st Japanese Gastric Cancer Congress

1999

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“…In Western countries, some studies reporting results aft er ER for AC of the esophagus suggested a favorable prognosis, although the rates of local and metachronous recurrence were relatively high (4.2 ~ 21.5 % ) ( 15,16 ). Similarly, in Japan, some studies suggested a favorable prognosis aft er ER for SCC of the esophagus (0 ~ 2.3 % ) ( 17,18 ), although the rates of local and metachronous recurrence were also relatively high (16.4 ~ 20 % ) ( 19,20 ). In addition, it had been reported that the rate of lymph node metastasis was low in both SCC ( 21 ) and AC ( 22 -26 ) when the lesion was limited to the superfi cial submucosa (SM1).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Nakagawa

Koike

Iijima

et al. 2014

American Journal of Gastroenterology

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OBJECTIVES:Few studies have simultaneously evaluated the long-term outcomes of endoscopic resection (ER) for squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus in Japan. The objective of this study was to evaluate the long-term outcomes of ER for superfi cial esophageal cancer in consecutive patients. METHODS:This was a retrospective study from a single institution. From April 2001 to June 2012, 204 patients with SCC and 26 patients with AC were included from a total of 355 consecutive patients who were treated by esophageal ER at the Tohoku University Hospital. Patients with submucosal invasion deeper than 200 μ m and lymphovascular involvement were excluded. The intervention followed was endoscopic therapy. RESULTS:Overall survival, disease-free survival, and recurrence rates were evaluated as long-term outcomes. In the SCC group, during the median observation time of 36.5 months (range, 6 -120 months), 22 (10.8 % ) patients experienced metachronous recurrence, 4 (2.0 % ) patients experienced local recurrence, and 27 (13.2 % ) patients died from causes unrelated to SCC. In the AC group, during the median observation time of 45.5 months (range, 6 -131 months), one patient (3.8 % ) experienced metachronous recurrence and two (7.7 % ) died from causes unrelated to AC. The cumulative 5-year overall survival rates were not signifi cantly different between SCC (75.9 % ) and AC (88.9 % ) ( P = 0.120). The cumulative 5-year disease-free survival rates of SCC (57.1 % ) were signifi cantly lower than those of AC (85.2 % ; P = 0.017). The cumulative 5-year recurrence rates of SCC (32.0 % ) were signifi cantly higher than those of AC (4.2 % ; P = 0.023). CONCLUSIONS:The rate of recurrence after ER was higher in patients with SCC than that in patients with AC. These fi ndings suggest that, by detecting AC of the esophagus earlier, a satisfactory prognosis without recurrence can be expected after ER in Japan, and more rigorous endoscopic follow-up is necessary after ER in patients with SCC than in those with AC.

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Endoscopic treatment of early oesophageal or gastric cancer.

Cited by 176 publications

References 10 publications

Adequate endoscopic mucosal resection for early gastric cancer obtained from the dissecting microscopic features of the resected specimens

Adequate endoscopic mucosal resection for early gastric cancer obtained from the dissecting microscopic features of the resected specimens

State of the art in the treatment of gastric cancer: from the 71st Japanese Gastric Cancer Congress

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

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