Endoscopic Treatment with Deflux<sup>®</sup> for Refluxing Duplex Systems

Rossini, C; Moriarty, Kevin P.; Courtney, Richard; Tashjian, David B.

doi:10.1089/lap.2008.0189

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…Nonreactive bulking agents have been used successfully in aesthetics, vesicoureteral reflux (VUR) in children, and stress urinary incontinence (SUI) for many years [28–30]. As a result, noninvasive treatment of FI with bulking agents has developed [31].…”

Section: Introductionmentioning

confidence: 99%

An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

Dodi

Jongen²,

Portilla

et al. 2010

Gastroenterology Research and Practice

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Fecal incontinence (FI) is the involuntary loss of rectal contents through the anal canal. Reports of its prevalence vary from 1–21%. Studies, have demonstrated a positive effect on FI symptoms with injectable bulking agents. This study evaluated the safety and efficacy of NASHA/Dx gel in the treatment of FI. One hundred fifteen eligible patients suffering from FI received 4 injections of 1 mL NASHA/Dx gel. Primary efficacy was based on data from 86 patients that completed the study. This study demonstrated a ≥50% reduction from baseline in the number of FI episodes in 57.1% of patients at 6 months, and 64.0% at 12 months. Significant improvements (P < .001) were also noted in total number of both solid and loose FI episodes, FI free days, CCFIS, and FIQL scores in all 4 domains. The majority of the treatment related AEs (94.9%) were mild or moderate intensity, and (98.7%) of AEs resolved spontaneously, or following treatment, without sequelae. Results of this study indicate NASHA/Dx gel was efficacious in the treatment of FI. Treatment effect was significant both in reduction of number of FI episodes and disease specific quality of life at 6 months and lasted up to 12 months after treatment.

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Section: Introductionmentioning

confidence: 99%

An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

Dodi

Jongen²,

Portilla

et al. 2010

Gastroenterology Research and Practice

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“…The cause of the early obstructions reported in the literature may be the physical obstruction caused by the injected material. 13 Rossini et al 14 reported that VUR in children can predispose patients to febrile UTIs. Repeated UTIs can lead to renal scarring, hypertension, and ultimately end-stage renal disease.…”

Section: Discussionmentioning

confidence: 99%

“…Although the resolution rate with open or laparoscopic surgery reportedly ranges from 90% to 98%, such treatment also has disadvantages such as the risks associated with invasive surgeries and a relatively long hospital stay. 14 Endoscopic subureteric injections have several advantages, including ease of administration, low cost, and proven safety. Even in the event of treatment failure, injections can be safely repeated.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and safety of Hyadex for treatment of vesicoureteral reflux: a multicenter experience

Oguz,

Yildiz,

Gecit

et al. 2023

J Int Med Res

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Objective This study was performed to evaluate the efficacy and safety of dextranomer/cross-linked hyaluronic acid (Hyadex) in patients with a clinical diagnosis of vesicoureteral reflux (VUR). Methods In this cross-sectional multicenter observational study, Hyadex was used in four different centers for the endoscopic treatment of VUR from 2020 to 2022. The study involved 74 patients (93 renal units) who were diagnosed with VUR according to voiding cystourethrography (VCUG) findings and were considered suitable for subureteric endoscopic treatment. The follow-up time (control VCUG time) was 3 months. Results In the VCUG evaluation, grade I VUR was found in 13 renal units, grade II in 23 renal units, grade III in 42 renal units, and grade IV in 12 renal units. The success rates of Hyadex treatment according to the degree of VUR were as follows: 84.6% for grade I, 82.6% for grade II, 71.4% for grade III, and 66.0% for grade IV. No major complications were observed. Conclusion Endoscopic subureteric Hyadex injection had high success rates in appropriately selected patients with VUR and may be used as the first-line treatment for children with VUR.

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“…However, as in single systems, EC is suitable only for mild to moderate VUR. 12,13 With decreased function of one of the moieties of the duplex collecting system kidney on DMSA scan or a MAG3 scan with dilatation due to obstruction or high grade reflux, or in case of breakthrough UTIs, surgical reimplantation of both ureters will often be done. 7 Chacko et al described in an 8-year retrospective review of 193 cases of complete DCS use of ipsilateral ureteroureterostomy in the surgical management of the severely dilated ureters.…”

Section: Discussionmentioning

confidence: 99%

Wrap Plication of Megaureter Around Normal-Sized Ureter for Complete Duplex System Reimplantations

et al. 2013

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Endoscopic Treatment with Deflux^® for Refluxing Duplex Systems

Abstract: We conclude that the Deflux procedure is a safe, effective minimally invasive treatment alternative for patients with refluxing duplex systems.

Cited by 11 publications

References 13 publications

An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

Efficacy and safety of Hyadex for treatment of vesicoureteral reflux: a multicenter experience

Wrap Plication of Megaureter Around Normal-Sized Ureter for Complete Duplex System Reimplantations

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Endoscopic Treatment with Deflux® for Refluxing Duplex Systems

Abstract: We conclude that the Deflux procedure is a safe, effective minimally invasive treatment alternative for patients with refluxing duplex systems.

Cited by 11 publications

References 13 publications

An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

Efficacy and safety of Hyadex for treatment of vesicoureteral reflux: a multicenter experience

Wrap Plication of Megaureter Around Normal-Sized Ureter for Complete Duplex System Reimplantations

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Product

Resources

About

Endoscopic Treatment with Deflux^® for Refluxing Duplex Systems