“…Despite being shown to be effective, widespread application of EUS-PDD is limited by its high complication rate, similar to EUS-BD [18,42,54]. In the EUS-RV technique, adverse event rates ranged from 0 to 25% and included pancreatitis, peripancreatic abscess, and pancreatic fluid leakage [26], whereas in EUS-TMD, the adverse event rates ranged from 0% to 67% and included abdominal pain, pancreatitis, bleeding, perforation, shaving of the guidewire coating, peripancreatic abscess, pseudocyst, and stent migration [18,29]. The higher adverse events observed in EUS-TMD may be related to the need for fistula tract dilation and the risk of pancreatic fluid leakage.…”