Endoscopic ultrasound guided radiofrequency ablation, for pancreatic cystic neoplasms and neuroendocrine tumors

Pai, Madhava; Habib, Nagy; Şentürk, Hakan; Lakhtakia, Sundeep; Reddy, Nageshwar; Cicinnati, Vito R.; Kaba, Iyad; Beckebaum, Susanne; Drymousis, Panagiotis; Kahaleh, Michel; Brugge, William R.

doi:10.4240/wjgs.v7.i4.52

Cited by 216 publications

(208 citation statements)

References 30 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…Then EUS-guided RFA, the other type of EUS-guided ablation, was investigated in the treatment of PCNs. Pai et al (10) used RFA in management of 6 patients with PCNs, and all the procedures were successfully finalized with a complete resolution in 2 out of 6 patients at a 3-to 6-month follow-up; two patients had mild abdominal pain and no post-procedural pancreatitis, and other complications were observed. That is the only clinical study on EUS-RFA for PCNs, to date and the preliminary data show the procedure is feasible and safe.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

New treatment of the pancreatic cystic neoplasm: Endoscopic ultrasonography-guided radiofrequency ablation combined with lauromacrogol ablation

Feng

Linghu

Chai

et al. 2018

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, the efficacy of ethanol lavage (EL) remains controversial and reports of patients undergoing surgery after EL showed a low rate of epithelial ablation (8,9). The septation in the PCNs also reduces the efficacy of EL (2,10). Then EUS-guided RFA, the other type of EUS-guided ablation, was investigated in the treatment of PCNs.…”

Section: Discussionmentioning

confidence: 99%

New treatment of the pancreatic cystic neoplasm: Endoscopic ultrasonography-guided radiofrequency ablation combined with lauromacrogol ablation

Feng

Linghu

Chai

et al. 2018

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…The only reported complications were limited abdominal pain. 80 More recently, Pai et al 81 went on to assess EUS-RFA with Habib catheter in 7 patients with inoperable adenocarcinoma of the pancreas. Two patients had neoplasms in the pancreatic body.…”

Section: Eus-guided Radiofrequency Ablationmentioning

confidence: 99%

“…5). 80 Pai et al 80 performed the first human study treating pancreatic cancer directly with EUS-RFA in eight patients, six of whom had cystic neoplasms. EUS-RFA was completed in all patients.…”

Section: Eus-guided Radiofrequency Ablationmentioning

confidence: 99%

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Luthra

Mishra

2017

Int J Gastrointest Interv

View full text Add to dashboard Cite

show abstract

“…The Medline database research shows 14 cases or case series of insulinoma EUS-guided ethanol ablation [17][18][19][20][21][22][23][24][25][26][27]. Moreover, there are also reports of alcoholic ablation of other pancreatic tumours of neuroendocrine and other origin (especially cystic pancreatic tumours) [28][29][30]. Some prospective studies are still in progress [29].…”

Section: Opis Przypadkumentioning

confidence: 99%

Successful EUS-guided ethanol ablation of insulinoma, four-year follow-up. Case report and literature review

Dąbkowski

Gajewska

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction: EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour. Ablation is recommended in patients who are poor surgical candidates or refuse surgery. We present a case of an 81-year-old female with symptomatic insulinoma, treated successfully with EUS-guided alcoholic ablation, along with a literature review including 28 other previously described cases. The effectiveness, safety of the therapy, and technical procedure-related issues are summarised. To the best of our knowledge, this is the first described case of successful insulinoma EUS-guided ablation in Poland. Material and methods:We searched the PubMed/Medline database to identify cases of EUS-guided alcoholic ablation. Our analysis included 14 articles (case reports or case series), with a total of 27 patients and 31 tumours described, published before February 2017. Results: The described tumours were relatively small (mean 13 mm), and the most common location was pancreatic head. The mean ethanol volume injected to the tumour was 1.8 ml and the concentration of infused alcohol varied from 95% to 98%.Side effects were observed in six cases; apart from one, they were mild and self-limiting. There was only one severe adverse event, treated conservatively with success. The median follow-up was 14.4 months (2-55 months). In all described cases ablation led to improvement of the symptoms and normalisation of glycaemia. Conclusions:The EUS-guided alcoholic ablation of insulinoma is a safe and effective method of treatment in patients who are poor surgical candidates and/or refuse surgery. The adverse effects are rare and mild and were observed when the volume of injected ethanol was equal to or above 3.0 ml. However, the data is limited, the follow-up is relatively short, and prospective studies are needed to confirm the long-term effects of treatment. The study shows also that there are important procedural differences (concentration and volume of alcohol, needle gauge, number of sessions) between the endoscopists, which should be specified. (Endokrynol Pol 2017; 68 (4): 472-479)

show abstract

Endoscopic ultrasound guided radiofrequency ablation, for pancreatic cystic neoplasms and neuroendocrine tumors

Abstract: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size.

Cited by 216 publications

References 30 publications

New treatment of the pancreatic cystic neoplasm: Endoscopic ultrasonography-guided radiofrequency ablation combined with lauromacrogol ablation

New treatment of the pancreatic cystic neoplasm: Endoscopic ultrasonography-guided radiofrequency ablation combined with lauromacrogol ablation

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Successful EUS-guided ethanol ablation of insulinoma, four-year follow-up. Case report and literature review

Contact Info

Product

Resources

About