Endosomal escapable cryo-treatment-driven membrane-encapsulated Ga liquid-metal transformer to facilitate intracellular therapy

Wang, Xuelin; Li, Xuedong; Duan, Minghui; Shan, Shaobo; Zhu, Xiaobiao; Chai, Yi; Wang, Hongzhang; Sun, Xuyang; Sheng, Lili; Qing, Guangchao; Rao, Wei; Hu, Liang; Chen, Junge; Jing, Liu

doi:10.1016/j.matt.2021.11.006

Cited by 42 publications

(32 citation statements)

References 60 publications

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“…[ 9,22,23,32 ] Meanwhile, micro‐/nanoscaled LM can also be processed into various shapes including sphere, rod, rice, and sword to adapt to the needs of different environments of organisms. [ 17,21,24 ] Owing to their processing flexibility and maneuverability, transformable LM droplets provide an emerging platform for drug delivery, anticancer therapy, and biosensors.…”

Section: Advantages Of Lms In Biomedicinementioning

confidence: 99%

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

“…[ 48 ] Furthermore, the morphology of Ga microparticles encapsulated with the cell membrane (Ga/MPs) could also be controlled to transform from the sphere to the cactus‐like structure at a low temperature (Figure 3b). [ 21 ] The volume expansion of Ga particles as well as the bonding point for Ga solidification and crystallization provided by ruptured cell membranes caused the formation of a cactus‐like structure. The transformations of Ga/MPs combined with the volume expansion during the phase transition could puncture the endosome membrane directly, achieving efficient drug endosomal escape.…”

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

“…LMs modified with enhanced targeting capacity will not only aggregate to disease sites with a higher targeting ratio but also act in a multifunctional manner, destroying lesions through combination therapy such as targeted drug delivery, targeted photothermal therapy, and synergistic chemo‐photothermal anticancer therapy ( Table 4 ). [ 17,21,22,24,34 ]…”

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

“…For instance, LMs decorated with cancer cell membranes from the same tumor cell origin exhibited good tumor targeting based on the homotypic binding, contributing to intracellular therapy with the low immune response of LMs in vivo (Figure 5b). [ 21 ]…”

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

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Emerging Liquid Metal Biomaterials: From Design to Application

et al. 2022

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Liquid metals (LMs) as emerging biomaterials possess unique advantages including their favorable biosafety, high fluidity, and excellent electrical and thermal conductivities, thus providing a unique platform for a wide range of biomedical applications ranging from drug delivery, tumor therapy, and bioimaging to biosensors. The structural design and functionalization of LMs endow them with enhanced functions such as enhanced targeting ability and stimuli responsiveness, enabling them to achieve better and even multifunctional synergistic therapeutic effects. Herein, the advantages of LMs in biomedicine are presented. The design of LM‐based biomaterials with different scales ranging from micro‐/nanoscale to macroscale and various components is explored in‐depth to promote the understanding of structure–property relationships, guiding their performance optimization and applications. Furthermore, the related advanced progress in the development of LM‐based biomaterials in biomedicine is summarized. Current challenges and prospects of LMs in the biomedical field are also discussed.

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Section: Advantages Of Lms In Biomedicinementioning

confidence: 99%

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

Section: Design Of Lm‐based Materialsmentioning

confidence: 99%

See 3 more Smart Citations

Emerging Liquid Metal Biomaterials: From Design to Application

et al. 2022

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Liquid Metal‐Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization

Zhu

Duan

Zhang

et al. 2023

Adv Funct Materials

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The drug-eluting microspheres that have been widely used in clinical treatments such as chemoembolization commonly suffer from inadequate drug loading and tracking difficulties. With inherent high density and excellent biocompatibility, liquid metal (LM) has been explored at the frontiers of medical imaging and clinical therapy. Herein, multifunctional microspheres (SA/LM/DOX) are reported with high drug loading and multimodal imaging by adsorbing silanized LM particles on sulfonated agarose microspheres (SA), which are capable of heating and accelerating drug release under an 808 nm near-infrared (NIR) laser. The negative SA microspheres can adsorb more positive drugs such as doxorubicin (DOX) up to 104 mg DOX per mL microspheres. It deserves to be mentioned that SA/LM/DOX microspheres have the function of multimodal imaging under computed tomography (CT), magnetic resonance imaging (MRI), and B-scan ultrasonography (US), which significantly facilitate location tracking during the embolization process. In rabbit ear central artery embolization, these microspheres are smoothly injected into the intended location of the vessel and successfully blocked blood flow, and eventually led to necrosis of rabbit ear. Overall, these microspheres with high drug loading capacity and multimodal contrast properties are promising candidates to be developed as new products for future clinical medicine.

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Dynamic Zinc in Liquid Metal Media as a Metal Ion Source for Highly Porous ZIF‐8 Synthesis

Zheng

Sharma

Kumeria

et al. 2023

Adv Funct Materials

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Liquid metals provide new dimensions for controlling and governing of reactions. The concept of freely moving metal solutes in liquid metals can be potentially used for enhancing and tuning interfacial reactions. In this work, zinc (Zn), as the solute metal is shown that, can move to the interface, enriching the interfacial area for the efficient synthesis of highly crystalline and porous zeolitic imidazolate framework‐8 (ZIF‐8). The highest rate of reaction is illustrated, and the best quality ZIF‐8, are obtained when a eutectic liquid metal system of Zn with gallium (Ga), containing 3.6 wt.% of Zn, is implemented. It is computationally shown that a combination of Ga activation and freely moving Zn leads to the highest reaction rate and better coordination with organic linkers. The comparisons with solid samples and non‐eutectic systems of Ga liquid demonstrate the advantages of eutectic mix. The work can be expanded to a variety of future interfacial reactions of zeolite imidazole frameworks for commercial scale up.

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Endosomal escapable cryo-treatment-driven membrane-encapsulated Ga liquid-metal transformer to facilitate intracellular therapy

Cited by 42 publications

References 60 publications

Emerging Liquid Metal Biomaterials: From Design to Application

Emerging Liquid Metal Biomaterials: From Design to Application

Liquid Metal‐Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization

Dynamic Zinc in Liquid Metal Media as a Metal Ion Source for Highly Porous ZIF‐8 Synthesis

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