Endosomal protein expression of γ1-adaptin is associated with tumor growth activity and relapse-free survival in breast cancer
Nobuhiro Hoshi,
Takefumi Uemura,
Kazunoshin Tachibana
et al.
Abstract:Background
γ1-Adaptin is a subunit of adaptor protein complex-1 (AP-1), which regulates intracellular transport between the trans-Golgi network (TGN) and endosomes. Since expression levels of AP-1 subunits have been reported to be associated with cell proliferation and cancer malignancy, we investigated the relationships between the immunohistochemical expression of γ1-adaptin and both clinicopathological factors and relapse-free survival (RFS) in breast cancer tissue.
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