Endosulfan and flutamide impair testicular development in the juvenile Asian catfish, Clarias batrachus

Assessment of the health status of wild fish inhabiting a cotton basin heavily impacted by pesticides in Benin (West Africa)

“…Comparable variations in sex steroids have been observed in goldfish, Carassius auratus, by Spano et al (2004) who found an increase in the plasma E2 levels together with a decrease in the T of males exposed to 1000 ppb of the herbicide atrazine. A similar elevation of E2 was reported by Rajakumar et al (2012) and Chakrabarty et al (2012) in walking catfish, Clarias batrachus, exposed to 2.5 ppb of endosulfan. However, in contrast to our study, these authors did not detect a decrease in the 11-KT.…”

2, 4-Dichloro-6-nitrophenol, a photonitration product of 2, 4-dichlorophenol, caused anti-androgenic potency in Chinese rare minnows (Gobiocypris rarus)

“…Decreased testosterone levels obtained from fish assays could used to assess anti-androgenic effect within the HPG-axis (Scholz and Mayer, 2008). Antiandrogens, such as vinclozolin and flutamide, have been shown to reduce plasma testosterone concentration in fish (Golshan et al, 2014;Rajakumar et al, 2012). Given the important roles of sex hormones in the gonad development and reproductive system, the antagonistic effect caused by DCNP to endocrine system need to raise concern over its adverse environmental health risks.…”

Pesticides used in cotton production affect reproductive development, endocrine regulation, liver status and offspring fitness in African catfish Clarias gariepinus (Burchell, 1822)

“…Reaction pattern Alterations C TA-E TA-1 TA-2 TE-1 TE-2 Testis by Rajakumar et al (2012) and Chakrabarty et al (2012) in the walking catfish Clarias batrachus exposed to 2.5 ppb of endosulfan. For these authors, endosulfan acts as a weak endocrine disruptor by interacting with the estrogen and androgen receptors and interfering with sex steroids.…”