Endosulfan causes the alterations of DNA damage response through ATM-p53 signaling pathway in human leukemia cells

Xu, Dan; Dong, Liang; Guo, Yubing; Sun, Yeqing

doi:10.1016/j.envpol.2018.03.044

Cited by 16 publications

(3 citation statements)

References 43 publications

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“…Table 1. Some examples of organochlorines pesticides, which are organic compounds with five or more chlorine atoms [10][11][12][13]. Table 1 shows the most common examples of pesticides within the organochlorine group, which are organic compounds with five or more chlorines atoms attached.…”

Section: Classification and Propertiesmentioning

confidence: 99%

Fate of Residual Pesticides in Fruit and Vegetable Waste (FVW) Processing

Nguyen

Rosello

Bélanger

et al. 2020

Foods

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Plants need to be protected against pests and diseases, so as to assure an adequate production, and therefore to contribute to food security. However, some of the used pesticides are harmful compounds, and thus the right balance between the need to increase food production with the need to ensure the safety of people, food and the environment must be struck. In particular, when dealing with fruit and vegetable wastes, their content in agrochemicals should be monitored, especially in peel and skins, and eventually minimized before or during further processing to separate or concentrate bioactive compounds from it. The general objective of this review is to investigate initial levels of pesticide residues and their potential reduction through further processing for some of the most contaminated fruit and vegetable wastes. Focus will be placed on extraction and drying processes being amid the main processing steps used in the recuperation of bioactive compounds from fruit and vegetable wastes.

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Section: Classification and Propertiesmentioning

confidence: 99%

Fate of Residual Pesticides in Fruit and Vegetable Waste (FVW) Processing

Nguyen

Rosello

Bélanger

et al. 2020

Foods

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“…To explain these results, one model (as discussed by Kannan et al [2000]) is that oxidative stress triggered by ENDO and/or its metabolites may lead to increased production of reactive oxygen species (ROS) among the exposed cells and that this agent in turn might trigger apoptosis. This triggering of apoptosis may be rapid (at higher concentrations) or delayed (at lower concentrations) and dependent on an inhibition of expression of antiapoptosis molecules or release of apoptogenic proteases to the cytosol (Vaux 2011;Zhang et al 2017;Xu et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells

Téllez‐Bañuelos

González-Ochoa

Ortiz‐Lazareno

et al. 2019

Journal of Immunotoxicology

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Endosulfan is a DDT-era organochlorine pesticide. Due to past and current environmental contamination, investigation of endosulfan exposure is of current importance. Acute high dose exposure precipitates neural/endocrine system damage, but the effects on the immune system and of lower doses are not well-characterized. Two relatively low concentrations of endosulfan (i.e. 0.1 and 17 mM ENDO) were investigated in an in vitro study using human peripheral blood mononuclear cells (PBMC) to understand effects of relatively low doses (0.1-25.0 mM [%0.04-10 ppm/40-10,000 ppb]) of ENDO upon normal human T-and B-lymphocytes and NK cells. The study here found that 17 mM ENDO inhibited phytohemagglutinin-M (PHA)-induced human PBMC proliferation. It was also seen that senescence and apoptosis among nonstimulated cells was increased, specifically within CD8 and NK populations, and that CD4:CD8 ratios also were increased. Treatment of non-stimulated PBMC with ENDO led to overall increases in production of tumor necrosis factor (TNF)-a, interferon (IFN)-c, interleukin (IL)-2,-4, and-6, and decreased production of anti-inflammatory IL-10, suggesting an immunosenescence secretory phenotype. Interestingly, when the cells were pre-stimulated with mitogen (PHA), ENDO became inhibitory against the mitogen-induced proliferation and cytokine formationwith the exception of that of TNFa and IL-6, suggesting differential effects of ENDO on activated cells. Thus, at the organismal level, ENDO might also display differential effects during states of autoimmune disease or chronic viral infection in the exposed host.

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“…OCPs such as endosulfan have a high persistence in aquatic ecosystems and low biodegradability and biomagnification in the tropical chain. They have also been associated with some types of cancer in humans (Xu, Liang, Guo, & Sun, 2018) but the role of endosulfan in leukemia cells has been unexplored. The aim of one of most representative study was to elucidate molecular mechanism of endosulfan-induced DNA damage response in human leukemia cells.…”

Section: Introductionmentioning

confidence: 99%

Pesticide residues in Junca Onion (Allium fistulosum) cultivated in Risaralda, Colombia

Vélez

Pulgarín

Betancur

et al. 2020

Semina: Ciênc. Agrár.

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By 2050, the world population will reach 9.2 billion, increasing the food demand by twice. Lowering loss due to pests is still challenging, where pesticides play an important role, but its indiscriminate use causes inadequate residual amounts to be present in foods. This study aims to monitor the organochlorine and organophosphorus pesticide residuality in Allium fistulosum cultivated in Risaralda, Colombia using gas chromatography - mass spectrometry (GC-MS). This method presented a highly sensitive (LOD: 0.11-7.15 µg kg-1), acceptable precision (RSD: 0.83-1.35%) and recoveries percentages between 46.32% - 118.67%. A greater presence of organochlorine pesticides banned or severely restricted by the Rotterdam agreement, such as 4,4'-DDT, was reported in samples of Allium fistulosum, with concentrations up to 221.22 ?g kg-1, while endrin with a concentration of 469.23 ?g kg-1 and its degradation products which exceed the maximum residue limite (MRL) for plant samples, reported by the Codex Alimentarius. According to this MRL, it was found that 73.1% of the samples have residual exceeding the allowed limit of organochlorine pesticides by more than forty times, posing a risk to human health and the ecosystem. Continuous monitoring and strict governmental control are required to reduce the exposure of humans and other living beings.

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Endosulfan causes the alterations of DNA damage response through ATM-p53 signaling pathway in human leukemia cells

Cited by 16 publications

References 43 publications

Fate of Residual Pesticides in Fruit and Vegetable Waste (FVW) Processing

Fate of Residual Pesticides in Fruit and Vegetable Waste (FVW) Processing

Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells

Pesticide residues in Junca Onion (Allium fistulosum) cultivated in Risaralda, Colombia

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