Endosymbionts as a substitute for the paternal genome in asexual haplodiploid insects

Fang-ying, Chen

doi:10.33612/diss.174044388

Cited by 1 publication

(2 citation statements)

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“…In hymenopterans the proper initiation of female development relies on a paternally derived signal. This might be in combination with a maternal effect (as in Nasonia vitripenis (Beukeboom and Van De Zande 2010)), or the paternal signal might be sufficient on its own (as is predicted to be the case in Leptopilina clavipes (Chen 2021)).…”

Section: Discussionmentioning

confidence: 99%

“…In Nasonia vitripennis, the maternal tra allele is transcriptionally repressed in the embryo, and a combination of maternally loaded traF mRNAs and a transcriptionally active paternal tra allele is necessary for female development (Beukeboom and Van De Zande 2010). In contrast, maternally provided traF is absent in Wolbachia-uninfected Leptopilina clavipes embryos (Chen 2021), and it may be the case that paternal activation of traF is sufficient. Importantly, tra isoforms differ 20 between Wolbachia-infected and Wolbachia-uninfected adult female Leptopilina clavipes.…”

Section: Discussionmentioning

confidence: 99%

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Identification of parthenogenesis-inducing effector proteins inWolbachia

Fricke,

Lindsey

2023

Preprint

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Bacteria in the genusWolbachiahave evolved numerous strategies to manipulate arthropod sex, including the conversion of would-be male offspring to asexually reproducing females. This so-called “parthenogenesis-induction” phenotype can be found in a number ofWolbachiastrains that infect arthropods with haplodiploid sex determination systems, including parasitoid wasps. Despite the discovery of microbe-mediated parthenogenesis more than 30 years ago, the underlying genetic mechanisms have remained elusive. We used a suite of genomic, computational, and molecular tools to identify and characterize two proteins that are uniquely found in parthenogenesis-inducingWolbachiaand have strong signatures of host-associated bacterial effector proteins. These putative parthenogenesis-inducing proteins have structural homology to eukaryotic protein domains including nucleoporins, the key insect sex-determining factor Transformer, and a eukaryotic-like serine-threonine kinase with leucine rich repeats. Furthermore, these proteins significantly impact eukaryotic cell biology in the model,Saccharomyces cerevisiae. We suggest these proteins are parthenogenesis-inducing factors and our results indicate this would be made possible by a novel mechanism of bacterial-host interaction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%