Endotension is Influenced by Wall Compliance in a Latex Aneurysm Model

Gawenda, M.; Knez, Peter; Winter, S.; Jaschke, Gregor; Wassmer, Gernot; Schmitz‐Rixen, T.; Brunkwall, Jan

doi:10.1016/j.ejvs.2003.10.013

Cited by 40 publications

(31 citation statements)

References 35 publications

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“…8 that the influence of EVG wall compliance on possible migration appears to be insignificant. Specifically, when the EVG wall compliance increases from 1.8 to 7.8% per 100 mmHg of blood pressure change, the migration force only decreases by 0.2 N. However, one cannot say that EVGwall compliance is not important because the degree of EVGwall compliance determines the sac pressure and hence the AAA wall-stress as a result of the fluid-structure interaction effects (Gawenda et al 2004;Li 2005).…”

Section: Factors Effecting Migration Force On Evgmentioning

confidence: 97%

“…Particularly, our simulation results indicated that even in the absence of any kind of endoleaks the sac pressure can be generated by the complex fluid-structure interactions between luminal blood flow, EVG wall, stagnant sac blood, and aneurysm wall. Gawenda et al (2003); Gawenda et al (2004) measured the sac pressure with in vitro stented aneurysm models under the conditions of non-endoleaks and found that, indeed, the sac pressure is determined by the EVG/AAA wall compliance.…”

Section: Impact Of Evg Presencementioning

confidence: 99%

“…For example, Gawenda et al (2004) measured the sac pressure for in vitro stented aneurysm (bulge) models which consisted of 6 or 12 layers of latex. For direct comparisons, the sac pressures were computed for similar configurations and flow conditions employing the ANSYS ALE FSI-solver.…”

Section: Validationmentioning

confidence: 99%

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Computational analysis of biomechanical contributors to possible endovascular graft failure

Kleinstreuer

Farber

2005

Biomech Model Mechanobiol

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This paper evaluates numerically coupled blood flow and wall structure interactions in a representative stented abdominal aortic aneurysm (AAA) model, leading potentially to endovascular graft (EVG) failure. A total of 12 biomechanical contributors to possible EVG migration were considered. The results show that after EVG insertion for the given model, the peak AAA sac-pressure was reduced to 14.2 mmHg (11.8% of p(lumen)), and hence the maximum von Mises wall stress and wall deformation dropped by factors of 20 and 10, respectively. Thus, an EVG can significantly reduce sac pressure, mechanical stress, pulsatile wall motion, and the maximum diameter in AAAs and hence prevent AAA rupture effectively. In the absence of endoleaks, elevated sac-pressure can still be caused by fluid-structure interactions between the EVG, stagnant blood, and AAA wall. EVG migration forces vary from 1.4 to 7 N for different EVG geometries, material properties, and hemodynamic conditions. AAA-neck angle, iliac bifurcation angle, neck aorta-to-iliac diameter ratio, EVG size, aorto-uni-iliac EVG, and hypertension play important roles in generating forces potentially leading to EVG migration.

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Section: Factors Effecting Migration Force On Evgmentioning

confidence: 97%

Section: Impact Of Evg Presencementioning

confidence: 99%

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Computational analysis of biomechanical contributors to possible endovascular graft failure

Kleinstreuer

Farber

2005

Biomech Model Mechanobiol

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“…The aneurysm sac pressurei sr educed when the aneurysm is successfully excluded (20) and at least in the experimental situation, the ePTFE graft reduces the intra-aneurysm sac pressurem oret han the Dacron graft (21) does. however,due to several other factors influencing the pressure, such as aneurysm sac volume, patent side branches, wall compliance and the systemic blood pressure ( 22,23), the importance in theclinicalsituation is not yet defined. The aorto-uniiliac system, though, leads to al ower sac pressure than the aortobi-iliac systems.…”

Section: Prostethic Materialsmentioning

confidence: 99%

How to Design the Optimal Stent Graft — What Have We Learnt?

Brunkwall¹

2008

Scand J Surg

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aBstractit is now more than 20 years since the first report of stent graft insertion in the human arterial system was published. the first "homemade" devices proved that the technique was possible but could not show any durability.Using these devices, it was possible to get agood seal but not agood anchorage. not even the first generation of commercially available stent grafts proved to be durable. first after gaining knowledge about the forces acting on the stent graft, it was realized that attachment was important for the durability and the hooks and barbs or al ongitudinal stability are needed to minimise the risk for distal migration. not much of adifference in the overall performance is noticed between the eptfe graft or the polyester graft or when comparing stainless steel stents with those made out of nitinol. the systems are made much more flexible and hydrophilic leading to ab etter performance and ag reater chance of percutaneous approach. the optimal stent graft is not out on the market yet, but hopefully will come with further development.

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“…26 Gawenda et al performed an in vitro experiment with latex aneurysm models of variable compliance. 27 After endovascularly excluding the aneurysm sac and measuring the circumferential compliance, as well as the sac's mean and pulse pressure relative to the systemic mean pressure, they concluded that the intrasac pressure was influenced inversely by the compliance of the aneurysm wall; a decrease in compliance resulted in an increase of the pressure parameters, showing that stiffer AAAs are associated with higher intrasac pressures, 27 which in turn can influence the sac shrinkage process. The implantation of a stent-graft has been associated with a decrease in the AAA compliance.…”

Section: Remodeling Of the Aneurysm Wallmentioning

confidence: 99%

Aneurysm sac shrinkage after endovascular treatment of the aorta: Beyond sac pressure and endoleaks

et al. 2012

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The isolation of the aneurysm sac from systemic pressure and its consequent shrinkage are considered criteria of success after endovascular repair (EVAR). However, the process of shrinkage does not solely depend on the intrasac pressure, the predictive role of which remains ambiguous. This brief review summarizes the additional pathophysiological mechanisms that regulate the biomechanical properties of the aneurysm wall and may interfere with the process of aneurysm sac shrinkage.

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Endotension is Influenced by Wall Compliance in a Latex Aneurysm Model

Abstract: This in vitro model demonstrated that the aneurysm sac mean pressure (ASPmean) and the aneurysm sac pulse pressure (ASPpulse) were significantly influenced by the compliance of the aneurysm wall. These data highlight the need for further studies regarding endotension.

Cited by 40 publications

References 35 publications

Computational analysis of biomechanical contributors to possible endovascular graft failure

Computational analysis of biomechanical contributors to possible endovascular graft failure

How to Design the Optimal Stent Graft — What Have We Learnt?

Aneurysm sac shrinkage after endovascular treatment of the aorta: Beyond sac pressure and endoleaks

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