Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines

Milošević, Nenad; Rütter, Marie; David, Ayelet

doi:10.3389/fmedt.2022.846065

Cited by 15 publications

(14 citation statements)

References 201 publications

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“…CAMs are a group of molecules that mediate the interaction among cells or between cells and a matrix, which are mainly distributed in the extracellular matrix (ECM) and exert regulatory functions by binding to specific receptors [ 24 ]. CAMs are involved in multiple types of pathological and physiological processes including the recognition of cell types, activation of cellular signal pathways, maintenance of the cellular structure, wound healing, coagulation, and tumor metastasis [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Yao

Wei

Jiang

2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. Febuxostat is a novel inhibitor of xanthine oxidase that suppresses cell adhesion molecules-mediated (CAMs) inflammation by activating KLF6. In this study, we explored the therapeutic function and potential mechanisms of febuxostat against allergic rhinitis (AR). Methods. We investigated the role of febuxostat through in vitro cell and in vivo animal experiments. Human nasal epithelial cells (hNECs) were cultured with histamine as an in vitro model. To establish the AR animal model, rats were exposed to ovalbumin. Rats were randomly grouped into control, model, 7.5 mg/kg febuxostat, and 15 mg/kg febuxostat groups. Results. In the in vitro study, we found significantly increased release of lactate dehydrogenase, elevated production of inflammatory factors and chemokines, and upregulated CAMs in histamine-treated hNECs. However, these results were significantly reversed for the 10 and 20 μM febuxostat treatments. The enhanced adhesion between hNECs and monocytes induced by histamine was dramatically repressed by febuxostat. In the vivo experiments, we observed that febuxostat ameliorated the increased sneezing times, the number of nose scratching episodes, and elevated HE pathological scores as well as alleviated the inflammation in nasal mucous tissues of AR mice. We found that KLF6, which was downregulated in histamine-treated hNECs, was significantly upregulated by febuxostat. The inhibitory effects of febuxostat on the expression levels of CAMs and adhesion between histamine-treated hNECs and monocytes were significantly abolished by the knockdown of KLF6. Conclusion. Febuxostat alleviates AR by inhibiting inflammation and monocyte adhesion in human nasal epithelial cells through the regulation of KLF6.

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Section: Discussionmentioning

confidence: 99%

Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Yao

Wei

Jiang

2022

Evidence-Based Complementary and Alternative Medicine

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“…The adhesion process of both leukocytes and monocytes is related to the presence of adhesive particles, i.e. ICAM-1 (intercellular adhesion molecule-1) and vascular target adhesion molecule-1 [7]. The induction of ICAM-1 secretion and an increase in the concentration of its soluble form in the serum (s-ICAM-1) is the result of the mediators of inflammation, e.g.…”

Section: Introductionmentioning

confidence: 99%

The concentration of IL-6, TNF-α, s-ICAM-1, and EBV DNA load – predictive factors of hepatological complications in children with infectious mononucleosis. A pilot study

Moppert¹,

Pawłowska²,

Domagalski³

et al. 2023

polp

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Introduction:The aim of the study was to assess the relationship between the concentration of pro-inflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor α (TNF-α), soluble intercellular adhesion molecule 1 (s-ICAM-1), and Epstein-Barr virus (EBV) DNA viraemia in children with infectious mononucleosis and hepatitis. Material and methods: The Epstein-Barr virus DNA load in the plasma of 36 immunocompetent patients aged 2.5-18 years with a symptomatic (sore throat, cervical lymph node enlargement, fatigue, and fever), antibody-confirmed EBV primary infection was assessed using a quantitative real-time polymerase chain reaction assay. The concentration of IL-6, s-ICAM-1, and TNF-α in serum was determined using enzyme-linked immunosorbent assay tests. Results: In a group of patients with infectious mononucleosis caused by EBV and viraemia > 3.5 log10 copies/ ml, shorter duration of symptoms, and higher serum levels of s-ICAM-1 and C-reactive protein (CRP) were confirmed. In group of children with EBV hepatitis and CRP > 5 mg/l, levels of s-ICAM-1, γ-glutamyl transpeptidase activity, count of total white blood cells and lymphocytes, and EBV DNA load were significantly higher than in patients with CRP < 5 mg/l. Among patients with EBV hepatitis the increase of s-ICAM-1 concentration correlated with the increase of IL-6 and TNF-α serum levels. Conclusions: The results suggest a higher risk of cholestatic complications in children with elevated CRP level. They indicate that EBV DNA viraemia in conjunction with an s-ICAM-1, IL-6, and TNF-α assessment may be helpful in selecting patients requiring hospitalization.

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“…Molecules involved in vascular response and leukopedesis have been widely investigated to enhance vector targeting including selectins, integrins, 30 cellular adhesion molecules (CAMs) 31 and so forth in the process of leukocyte capture, adhesion, and rolling 32,33 . Wherein initial tethering and rolling of leukocytes on inflamed endothelial cells are facilitated by selections, and the ensuing firm adhesion and transmigration are mainly mediated by leukocyte integrin's interacting with CAMs 34 …”

Section: Introduction Of Inflammation Core Eventsmentioning

confidence: 99%

“…32,33 Wherein initial tethering and rolling of leukocytes on inflamed endothelial cells are facilitated by selections, and the ensuing firm adhesion and transmigration are mainly mediated by leukocyte integrin's interacting with CAMs. 34 The selectins constitute a group of three members namely L-selectin, P-selectin and E-selectin. The expression of P-selectin (CD62P) is restricted in activated platelets and endothelia.…”

Section: Introduction Of Inflammation Core Eventsmentioning

confidence: 99%

Development of nanoparticle‐based drug delivery system for inflammation treatment and diagnosis

Qin,

Wang,

Zou

et al. 2023

MedComm – Biomaterials and Applications

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Inflammation is a prevalent pathological process that accompanies the onset and progression of numerous acute and chronic diseases including rheumatoid arthritis, sepsis, pancreatitis, atherosclerosis, ischaemic brain/heart disease and so forth. However, conventional anti‐inflammatory drugs have certain disadvantages such as nonspecific tissue distribution, low bioavailability, and a short half‐life, resulting in off‐target side effects and limited efficacy in disease control. To address these issues, nanoparticles have emerged as a novel therapeutic paradigm in this field to attain inflammation targeting and improve drug pharmacokinetic properties via the well‐recognized enhanced permeability and retention (EPR) effect at the inflammatory site. Existing reviews are predominantly centered on inflammatory pathology introduction and vector design. As a necessary complement, this review mainly elaborates on the introduction of inflammation core events, the history of the drug delivery system for anti‐inflammatory drugs, the action mechanism of inflammation targeting vectors, nanoparticle classification based on targeting moiety, methods to combine targeting moiety with core nanoparticles, techniques to assess targetability in vitro and in vivo and finally the challenges and prospects in this field. The information provided herein offers practical guidance to researchers seeking to develop and evaluate inflammation targeting vectors rationally.

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Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines

Cited by 15 publications

References 201 publications

Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

Febuxostat Alleviates Allergic Rhinitis by Inhibiting Inflammation and Monocyte Adhesion in Human Nasal Epithelial Cells via Regulating KLF6

The concentration of IL-6, TNF-α, s-ICAM-1, and EBV DNA load – predictive factors of hepatological complications in children with infectious mononucleosis. A pilot study

Development of nanoparticle‐based drug delivery system for inflammation treatment and diagnosis

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