Endothelial Cell Lining of PET Vascular Prostheses: Modification with Degradable Polyester-based Copolymers and Adhesive Protein Multi-layers

Filova, Jaroslav Chlupac Elena

doi:10.4172/2157-7552.1000139

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…Differences in the mechanical properties between the prosthetic graft and the native aorta can have unwanted hemodynamic effects such as pressure and flow of the vasculature, causes excessive stresses at the suture lines which can lead to anastomotic aneurysms, intimal hyperplasia and eventually to graft failure (23). It is well-known that PET vascular replacements have relatively good mechanical characteristics in terms of their ability to withstand cyclic loads produced by pulsatile blood flow (24). However, compared to the native blood vessels, PET prosthetic materials are stiffer and less compliant.…”

Section: Commercialized Vascular Membranementioning

confidence: 99%

Tissue Engineering for Cardiovascular Regeneration: Brief Review on Scaffold Fabrication

Parveen Malick,

Vangetaraman,

Saidin

et al. 2024

HumEnTech

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Tissue engineering is the combination of engineering and fundamental sciences to develop an artificial organ that derived from the tissue human sources. It involves the construction of three main pillars include cell sources, scaffold materials and biological factors. These three important elements are necessary to be incorporated and integrated well, to construct a functional artificial tissue engineering product. Few applications can be associated with the expansion of tissue engineering where cardiovascular regeneration is one of the targets of tissue engineering. Among the fabrication techniques, electrospinning, three-dimensional printing, molding and decellularization, are four engineering methods that are commonly used in fabricating scaffolds for cardiovascular tissue engineering. One of the purposes of the emerging of cardiovascular tissue engineering is the limitation of current commercialized patches or membranes that often cause post-complications following the cardiovascular treatments. This review paper covering a brief introduction on the tissue engineering for cardiovascular regeneration, focusing on the scaffold fabrication.

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Section: Commercialized Vascular Membranementioning

confidence: 99%

Tissue Engineering for Cardiovascular Regeneration: Brief Review on Scaffold Fabrication

Parveen Malick,

Vangetaraman,

Saidin

et al. 2024

HumEnTech

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Surface-transformed osteoinductive polyethylene terephthalate scaffold as a dual system for bone tissue regeneration with localized antibiotic delivery

Sreeja

Muraleedharan

Varma

et al. 2020

Materials Science and Engineering: C

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The Role of Smooth Muscle Cells in Vessel Wall Pathophysiology and Reconstruction Using Bioactive Synthetic Polymers

Pařízek¹,

Novotná²,

Bačáková

2011

Physiol Res

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This review summarizes recent trends in the construction of bioartificial vascular replacements, i.e. hybrid grafts containing synthetic polymeric scaffolds and cells. In these advanced replacements, vascular smooth muscle cells (VSMC) should be considered as a physiological component, although it is known that activation of the migration and proliferation of VSMC plays an important role in the onset and development of vascular diseases, and also in restenosis of currently used vascular grafts. Therefore, in novel bioartificial vascular grafts, VSMCs should be kept in quiescent mature contractile phenotype. This can be achieved by (1) appropriate physical and chemical properties of the material, such as its chemical composition, polarity, wettability, surface roughness and topography, electrical charge and conductivity, functionalization with biomolecules and mechanical properties, (2) appropriate cell culture conditions, such as composition of cell culture media and dynamic load, namely cyclic strain, and (3) the presence of a confluent, mature, semipermeable, non-thrombogenic and non-immunogenic endothelial cell (EC) barrier, covering the luminal surface of the graft and separating the VSMCs from the blood. Both VSMCs and ECs can also be differentiated from stem and progenitor cells of various sources. In the case of degradable scaffolds, the material will gradually be removed by the cells and will be replaced by their own new extracellular matrix. Thus, the material component in advanced blood vessel substitutes acts as a temporary scaffold that promotes regeneration of the damaged vascular tissue.

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Endothelial Cell Lining of PET Vascular Prostheses: Modification with Degradable Polyester-based Copolymers and Adhesive Protein Multi-layers

Abstract: Background: Bypass surgery for atherosclerosis is confronted with the absence of endothelial cells in the lumen of vascular prosthesis in humans. This imposes a risk of thrombosis. New biomaterials try to minimize surface thrombogenicity.

Cited by 4 publications

References 54 publications

Tissue Engineering for Cardiovascular Regeneration: Brief Review on Scaffold Fabrication

Tissue Engineering for Cardiovascular Regeneration: Brief Review on Scaffold Fabrication

Surface-transformed osteoinductive polyethylene terephthalate scaffold as a dual system for bone tissue regeneration with localized antibiotic delivery

The Role of Smooth Muscle Cells in Vessel Wall Pathophysiology and Reconstruction Using Bioactive Synthetic Polymers

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