2022
DOI: 10.1172/jci.insight.154379
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Endothelial cell polarity and extracellular matrix composition require functional ATP6AP2 during developmental and pathological angiogenesis

Abstract: The (Pro)renin receptor ((P)RR), also known as ATP6AP2, is a single-transmembrane protein that is implicated in a multitude of biological processes. However, the exact role of ATP6AP2 during blood vessel development remains largely undefined. Here, we use an inducible endothelial cell (EC)-specific Atp6ap2 knockout mouse model to investigate the role of ATP6AP2 during both physiological and pathological angiogenesis in vivo. We observed that postnatal deletion of Atp6ap2 in ECs results in cell migration defect… Show more

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Cited by 13 publications
(8 citation statements)
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“…Scratch wound healing assay was performed as previously described [ 22 ]. Briefly, a scratch was made using P200 pipette tip on confluent control and Zmiz1 knockdown HDLECs.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Scratch wound healing assay was performed as previously described [ 22 ]. Briefly, a scratch was made using P200 pipette tip on confluent control and Zmiz1 knockdown HDLECs.…”
Section: Methodsmentioning
confidence: 99%
“…RNA extraction and processing for sequencing was performed as previously described [ 22 ]. Briefly, total RNA was extracted from control and ZMIZ1 siRNA transfected HDLECs using GeneJET RNA Purification Kit (Thermo Fisher Scientific, K0732).…”
Section: Methodsmentioning
confidence: 99%
“…P7 cortices were dissected (n = 3 per genotype). RNA extraction and processing for sequencing were performed as previously described ( 90 , 91 ). Briefly, total RNA was extracted from wildtype and Zmiz1-KO cortex.…”
Section: Methodsmentioning
confidence: 99%
“…PARVA, part of the cell-cell communication pathway, is involved in reorganizing the actin cytoskeleton and cell polarity, was identified for the first time in the context of ADAD. 85,86 In summary, by performing network and subsequent pathway analyses, we were able to provide a better overview of the pathways that are disrupted in ADAD at different stages of the disease.…”
Section: Co-expression Network Analysis Identified Modules That Captu...mentioning
confidence: 99%