2004
DOI: 10.1152/japplphysiol.00236.2004
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Endothelial cells as early sensors of pulmonary interstitial edema

Abstract: We studied responses of endothelial and epithelial cells in the thin portion of the air-blood barrier to a rise in interstitial pressure caused by an increase in extravascular water (interstitial edema) obtained in anesthetized rabbits receiving saline infusion (0.5 ml.kg(-1).min(-1) for 3 h). We obtained morphometric analyses of the cells and of their microenvironment (electron microscopy); furthermore, we also studied in lung tissue extracts the biochemical alterations of proteins responsible for signal tran… Show more

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Cited by 49 publications
(39 citation statements)
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“…5B,D,G). No signs of interstitial edema (Conforti et al, 2002;Daffara et al, 2004) or inflammatory infiltration were detected.…”
Section: Ultrastructural Findingsmentioning
confidence: 89%
“…5B,D,G). No signs of interstitial edema (Conforti et al, 2002;Daffara et al, 2004) or inflammatory infiltration were detected.…”
Section: Ultrastructural Findingsmentioning
confidence: 89%
“…When lungs suffer relatively mild forms of interstitial pulmonary edema, the lipid microdomains of lung cell surface membranes undergo a substantial reorganization (158,159). The functional consequence of membrane remodeling, which is almost certainly accompanied by changes in surface protein expression, remains to be explored.…”
Section: Cellular Remodeling: Prevention Of Plasma Membrane Woundingmentioning
confidence: 99%
“…Although lung overexpansion exacerbates lung injury in mechanically ventilated patients (1), our aim was to avoid excessive hyperinflation that might elicit independent signaling effects secondary to events such as pulmonary edema (23) and stress fracture (24). Previous reports indicate that stretch-mediated increase of vascular diameter by â€«Ùâ€Ź 8% induces Ca 2Ï© and NO signaling in lung endothelial cells in situ (25,26).…”
Section: Discussionmentioning
confidence: 99%