1.12 Clinical Problems - COPD 2016
DOI: 10.1183/13993003.congress-2016.pa3661
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Endothelial dysfunction and systemic inflammation during acute exacerbations of COPD

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“…Furthermore, BAFF levels in BAL B-cells were inversely correlated with the severity of airflow limitation, suggesting that B-cell expansion, mediated by BAFF, may be a critical event in the pathogenesis of the disease. The problem of endothelial dysfunction was tackled by V ukic D ugac et al [ 2 ] in two phenotypically distinct groups of frequent and infrequent COPD exacerbators. Von Willebrand factor, as a marker of endothelial dysfunction, and C-reactive protein and fibrinogen, as markers of systemic inflammation, were measured in 117 consecutive subjects; a significantly higher increase of all markers in frequent than infrequent exacerbators was found.…”
Section: Clinical Problemsmentioning
confidence: 99%
“…Furthermore, BAFF levels in BAL B-cells were inversely correlated with the severity of airflow limitation, suggesting that B-cell expansion, mediated by BAFF, may be a critical event in the pathogenesis of the disease. The problem of endothelial dysfunction was tackled by V ukic D ugac et al [ 2 ] in two phenotypically distinct groups of frequent and infrequent COPD exacerbators. Von Willebrand factor, as a marker of endothelial dysfunction, and C-reactive protein and fibrinogen, as markers of systemic inflammation, were measured in 117 consecutive subjects; a significantly higher increase of all markers in frequent than infrequent exacerbators was found.…”
Section: Clinical Problemsmentioning
confidence: 99%