Endothelial dysfunction as a long-term effect of late onset hypertensive pregnancy disorders: High BMI is key

Alma, Lisa J.; Groot, Christianne de; Menezes, Renée X. de; Hermes, Wietske; Hordijk, Peter L.; Kovačević, Igor

doi:10.1016/j.ejogrb.2018.04.003

Cited by 13 publications

(9 citation statements)

References 24 publications

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“…Pre-pregnancy obesity has been reported to be an independent risk factor for subsequent hypertension among women who ever experienced preeclampsia [43]. Furthermore, women may have elevated markers of long-term endothelial dysfunction if they were overweight before developing preeclampsia [44]. Although we restricted our analysis to women with complete information on antenatal BMI, we cannot rule out the possibility of unmeasured confounding from dyslipidaemia or recurrent preeclampsia, particularly if women with a first episode of preeclampsia received anti-hypertensive treatment or alternative cardio-protective intervention post partum.…”

Section: Plos Medicinementioning

confidence: 99%

Hypertensive disorders of pregnancy and the risk of chronic kidney disease: A Swedish registry-based cohort study

et al. 2020

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Background Hypertensive disorders of pregnancy (HDP) (preeclampsia, gestational hypertension) are associated with an increased risk of end-stage kidney disease (ESKD). Evidence for associations between HDP and chronic kidney disease (CKD) is more limited and inconsistent. The underlying causes of CKD are wide-ranging, and HDP may have differential associations with various aetiologies of CKD. We aimed to measure associations between HDP and maternal CKD in women who have had at least one live birth and to identify whether the risk differs by CKD aetiology. Methods and findings Using data from the Swedish Medical Birth Register (MBR), singleton live births from 1973 to 2012 were identified and linked to data from the Swedish Renal Register (SRR) and National Patient Register (NPR; up to 2013). Preeclampsia was the main exposure of interest and was treated as a time-dependent variable. Gestational hypertension was also investigated as a secondary exposure. The primary outcome was maternal CKD, and this was classified into 5 subtypes: hypertensive, diabetic, glomerular/proteinuric, tubulointerstitial, and other/nonspecific CKD. Cox proportional hazard regression models were used, adjusting for maternal age, country of origin, education level, antenatal BMI, smoking during pregnancy, gestational diabetes, and parity. Women with pre-pregnancy comorbidities were excluded. The final sample consisted of 1,924,409 women who had 3,726,554 singleton live births. The mean (±SD) age of women at first delivery was 27.0 (±5.1) years. Median follow-up was 20.7 (interquartile range [IQR] 9.9-30.0) years. A total of 90,917 women (4.7%) were diagnosed with preeclampsia, 43,964 (2.3%) had gestational hypertension, and 18,477 (0.9%) developed CKD. Preeclampsia was associated with a higher risk of developing CKD during

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Section: Plos Medicinementioning

confidence: 99%

Hypertensive disorders of pregnancy and the risk of chronic kidney disease: A Swedish registry-based cohort study

et al. 2020

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“…It is believed that endothelial cells phagocytose the deported trophoblasts and apoptosis-derived debris to suppress the activation of endothelial cells caused by the low level of necrotic trophoblastic debris during normal pregnancy (Chen et al, 2006; Chen Q. et al, 2012). When this process becomes dysregulated, the apoptotic trophoblastic debris-mediated protection of endothelial cells is lost and excessive necrotic debris of trophoblasts could then activate endothelial cells or prevent them from self-renewal (Kertesz et al, 2000; Gupta et al, 2005c), consistent with endothelial injury being the pathological hallmark of PE (Alma et al, 2018).…”

Section: Sdevs and Pe-associated Endothelial Injurymentioning

confidence: 99%

Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia

Han

Huang

et al. 2019

Front. Physiol.

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Preeclampsia is a common obstetric complication associated with pregnancy and it endangers lives of the mother and the infant. The histopathological changes associated with preeclampsia include systemic endothelial dysfunction, persistent inflammatory state, and coagulation and fibrinolysis dysregulations. Preeclampsia is considered to be caused by the systemic vasoconstriction of small arteries and disruption of the endothelial integrity, resulting in hypertension, proteinuria, and multiple organ dysfunction. However, mediators that trigger or propagate the pathology of preeclampsia remain poorly defined. Syncytiotrophoblast-derived extracellular vesicles (SDEVs) are increasingly recognized as a key mediator for the development of preeclampsia, but the underlying mechanisms through which these SDEVs are released and induce systemic responses are not fully understood. This review focuses on multiple roles of SDEVs in the pathogenesis of preeclampsia.

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“…The probable explanation might be that high occurrence of cardiovascular disease such as hypertension, hyperlipidemia and diabetes along with the increasing BMI contributed to the damage of microvascular endothelial structure. 38 …”

Section: Resultsmentioning

confidence: 99%

Body Mass Index Influence on the Clinical Outcomes for Nonvalvular Atrial Fibrillation Patients Admitted to a Hospital Treated with Direct Oral Anticoagulants: A Retrospective Cohort Study

Li¹,

Zuo²,

Ji³

et al. 2021

DDDT

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Endothelial dysfunction as a long-term effect of late onset hypertensive pregnancy disorders: High BMI is key

Cited by 13 publications

References 24 publications

Hypertensive disorders of pregnancy and the risk of chronic kidney disease: A Swedish registry-based cohort study

Hypertensive disorders of pregnancy and the risk of chronic kidney disease: A Swedish registry-based cohort study

Syncytiotrophoblast-Derived Extracellular Vesicles in Pathophysiology of Preeclampsia

Body Mass Index Influence on the Clinical Outcomes for Nonvalvular Atrial Fibrillation Patients Admitted to a Hospital Treated with Direct Oral Anticoagulants: A Retrospective Cohort Study

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