Endothelial dysfunction following drug-eluting stent implantation: A systematic review of the literature

All-cause mortality and cardiovascular events with nicorandil in patients with IHD: Systematic review and meta-analysis of the literature

“…The potential reasons of the different benefits of nicorandil in IHD patients with and without hemodialysis are not clear. It is well known that the ischemic injuries of the heart in hemodialysis patients with IHD might be induced not only by obstructive arteries but also by the increased inflammation [42,43], microvascular dysfunction [44,45], endothelial dysfunction [46][47][48][49], platelet dysfunction, thrombosis, and vasomotor dysfunction [50,51]. The biological functions of nicorandil of nitric oxide release and its antiinflammatory effects might partially explain its benefit effect in hemodialysis individuals.…”

Bioresorbable scaffold — A magic bullet for the treatment of coronary artery disease?

“…More recent data suggested that second generation DES (everolimus-eluting, biolimus-eluting, zotarolimus eluting) do not cause this effect (71)(72)(73). Bioresorbable scaffolds disappear over time, thus it is presumed that in BVS-implanted arteries, the initial resistance to vasomotion induced by vasoactive drugs decreases gradually, thereby allowing the potential recovery of normal vasomotor tone (74).…”

Prevalence of coronary artery spasm after stent placement and its association with inflammation

“…Recent studies have shown impaired coronary vasomotion in the peristent region [1] and development of coronary artery spasm (CAS) after sirolimus-eluting stent and paclitaxel-eluting stent implantation [2]. In such cases, stent lengths were longer in spastic coronary arteries than in non-spastic coronary arteries [2].…”