Endothelial Dysfunction: From Physiology to Therapy

Mombouli, Jean-Vivien; Vanhoutte, Paul M.

doi:10.1006/jmcc.1998.0844

Cited by 426 publications

(299 citation statements)

References 5 publications

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“…Interestingly, dysfunctional endothelium-dependent vasodilator responses have been demonstrated in the vasculature of various hypertensive animal models. 2 However, endothelial abnormalities associated with hypertension may not fully explain the mechanism for the decreased erectile response in hypertensive rat models. A large part of nitric oxide release during erection is thought to be generated by neuronal nitric oxide synthase (nNOS) through the stimulation of the nonadrenergic, noncholinergic nerves to the corpus cavernosum.…”

Section: Discussionmentioning

confidence: 99%

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Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats

et al. 2001

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Numerous etiological studies have established a positive clinical association between hypertension and erectile dysfunction. However, to date, the mechanism underlying this dysfunction remains to be established. In this study, we demonstrate the presence of erectile dysfunction in two rat models of hypertension, and hypothesize that increased vasoconstrictor signaling via Rhokinase contributes to the decreased erectile response. We found deoxycorticosterone-salt and stroke prone-spontaneously hypertensive rats to exhibit a decreased erectile response, recorded as intracavernosal pressure=mean arterial pressure (ICP=MAP) upon electrical stimulation of the major pelvic ganglion. As previously shown, inhibition of Rho-kinase activity by intracavernosal injection of the selective inhibitor, Y-27632, resulted in an increase in ICP=MAP. However, Y-27632 was significantly less effective at increasing ICP=MAP in the hypertensive as compared to normotensive rats. Additionally, intracavernosal injection of Y-27632 potentiated the voltagestimulated increase in ICP=MAP in both hypertensive and normotensive rats, but was less effective at potentiating the voltage-mediated erectile response in the hypertensive rats. Altogether, our data demonstrate a decreased erectile response in a mineralocorticoid and genetic model of hypertension, and suggest the role of increased cell signaling by Rho-kinase in the vasoconstrictor activity of erectile dysfunction associated with hypertension.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3] The pathological changes resulting from altered vascular functioning include injury to the brain, kidney and heart. Various studies have established a clinical correlation between incidence of hypertension and erectile dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats

et al. 2001

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“…The endothelium regulates the contractility of the underlying vascular smooth muscle cells by releasing a number of factors, the most important of which are the nitric oxide (NO) and endothelium derived hyperpolarizing factor (EDHF). These two factors play a major role in the controlling of vascular homeostasis [46–49]. Endothelial NO-release is related to an activation of the endothelial nitric oxide synthase (eNOS) and can be stimulated by various agonists.…”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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“…Angiotensin II could be partly responsible for endothelial dysfunction because it induces resistance to the vasodilatory effect of the NO, so that by stopping the production of angiotensin II the direct and indirect vasoconstrictive effects of this peptide are blocked. 9 Another possible contribution of DM to endothelial dysfunction is the impairment of the lipid profile; it has been demonstrated that hypercholesterolaemia accelerates the deficit of intracellular arginine, reducing the activity of the NO synthetase, lowering the production of NO and increasing endothelin secretion predominating the vasoconstrictive response. It is important to remark that the development of the atherosclerotic process begins with an initial injury produced either by a metabolic trauma like diabetes, hypercholesterolaemia, smoking, infections, ischaemia, etc; or by a physical trauma such as hypertension and percutaneous coronary angioplasty.…”

Section: Journal Of Human Hypertensionmentioning

confidence: 99%

Diabetes and hypertension physiopathology and therapeutics

et al. 2000

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Diabetes mellitus by itself, is a frequent and increasing public health problem. The prevalence in most Western countries varies between 2 to 5% and it is rapidly increasing in Asiatic countries due to changes in dietary habits during the last years. The association between diabetes mellitus and hypertension has been described in 60 to 65% of diabetics. In hypertension we find insulin resistance mainly in skeletal muscle involving the conversion of glucose to glycogen independently of blood flow. The degree of resistance is related to the severity of hypertension and varies between races. States of

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Endothelial Dysfunction: From Physiology to Therapy

Cited by 426 publications

References 5 publications

Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats

Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Diabetes and hypertension physiopathology and therapeutics

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