Endothelial dysfunction in patients with pulmonary thromboembolism: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Kurtipek, Ercan; Buyukterzi, Zafer; Buyukterzi, Meral; Alpaydın, Mehmet Sertaç; Erdem, Sami

doi:10.1111/crj.12308

Cited by 34 publications

(32 citation statements)

References 23 publications

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“…Moreover, ED independently predicted endothelial dysfunction among middle‐aged men presenting for wellness screening (Peyton et al ., ). An association between NLR and endothelial dysfunction was previously reported in men with pulmonary thromboembolism (Kurtipek et al ., ).…”

Section: Discussionmentioning

confidence: 97%

The role of neutrophil‐to‐lymphocyte ratio in men with erectile dysfunction—preliminary findings of a real‐life cross‐sectional study

et al. 2018

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The aim of this study was to investigate the role of systemic inflammation by means of the neutrophil-to-lymphocyte ratio (NLR) in men with erectile dysfunction (ED). Complete demographic, clinical, and laboratory data from 279 consecutive men with newly diagnosed ED were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). A complete blood count was requested for every man, and the NLR was calculated for every individual. Patients were invited to complete the IIEF questionnaire. Logistic regression models tested the odds (OR, 95% CI) of severe ED (defined as IIEF-EF <11, according to Cappelleri's criteria) after adjusting for age, BMI, comorbidities (CCI >0), metabolic syndrome, NLR, cigarette smoking, and color duplex Doppler ultrasound parameters. Likewise, LNR values were also dichotomized according to the most informative cutoff predicting severe ED using the minimum p value approach. Median [IQR] age of included men was 51 [40-64] years. Of all, 87 (31%) men had severe ED. Men with severe ED were older (median [IQR] age: 61 [47-67] vs. 49 [39-58] years) and had a higher rate of CCI>0 [46/87 (53%) vs. 44/192 (23%) patients]. Thereof, NLR was dichotomized according to the most informative cutoff (NLR>3); patients with severe ED more frequently had NLR>3 as compared to all other ED patients [namely, 18/87 (21%) vs. 13/192 (7%)]. At multivariable logistic regression analysis, NLR>3.0 emerged as an independent predictor (OR [CI] 2.43 [1.06; 5.63]) of severe ED, after accounting for other clinical variables. A NLR>3 increased the risk of having severe ED in our cohort, boosting the already existing evidence linking systemic inflammation to ED. Moreover, this easily obtainable index can be clinically useful in better risk-stratifying patients with ED.

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Section: Discussionmentioning

confidence: 97%

The role of neutrophil‐to‐lymphocyte ratio in men with erectile dysfunction—preliminary findings of a real‐life cross‐sectional study

et al. 2018

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“…Altintas et al [ 33 ] found that a higher PLR is significantly associated with the presence of silent brain infarcts (SBIs) in patients with paroxysmal atrial fibrillation (PAF) ( P = 0.001); increased PLR might be a factor that induces inflammatory processes on SBIs in patients with PAF even with low CHA2DS2–VASc scores. Kurtipek et al [ 34 ] showed that in pulmonary thromboembolism (PTE) patients, using noninvasive ultrasonography combined with higher PLR in endothelial dysfunction diagnosis is effective. The study of Zuo et al [ 35 ] proved that the PLR was a predictive marker of thrombogenesis in nonvalvular atrial fibrillation.…”

Section: Discussionmentioning

confidence: 99%

Value of the platelet-to-lymphocyte ratio in the prediction of left ventricular thrombus in anterior ST-elevation myocardial infarction with left ventricular dysfunction

Zhang

et al. 2020

BMC Cardiovasc Disord

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Background The predictors of left ventricular thrombus (LVT) formation are not well defined in the contemporary era, especially in those patients at high risk. We aimed to evaluate whether the platelet/lymphocyte ratio (PLR) is valuable in the determination of LVT formation in patients with anterior ST-elevation myocardial infarction (STEMI) and left ventricular (LV) dysfunction. Methods The LVT group (n = 46) was identified from anterior STEMI patients with LV dysfunction who were treated with primary percutaneous coronary intervention (PCI) from January 2017 to December 2019 at the China-Japan Union Hospital of Jilin University. The no-LVT group (n = 92) were also selected from the same batch of patients and were age- and sex-matched to the patients with LVT. The PLR was determined at admission and was calculated as the ratio of the platelet count to the lymphocyte count using the complete blood count. The presence of LVT was determined by echocardiography. Results The PLR were significantly higher in patients with LVT than in no-LVT group (p = 0.001). In a receiver operator characteristic curve (ROC) analysis, using a cut-off value of 118.07 (AUC 0.673, 95% CI: 0.574–0.771, P = 0.001), the PLR could independently predict the occurrence of LVT. Multivariate analysis showed that an increased PLR (OR = 1.011, 95% CI: 1.004–1.018, P = 0.002), the presence of a left ventricular aneurysm (OR = 46.350, 95% CI: 5.659–379.615, P < 0.001) and increased DTBT (OR = 1.005, 95% CI: 1.001–1.009, P = 0.012) were independent predictors of LVT formation. Conclusions In acute anterior STEMI patients with LV dysfunction, an increased PLR and DTBT and the presence of an LV aneurysm were independent predictors of LVT formation. A larger prospective study is warranted to evaluate this result. Trial registration This study was registered (May 4, 2019) on Chinese Clinical Trial Registry (ChiCTR-DDD-17011214).

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“…[ 13 , 14 ] Recently, the pathophysiology of severe PE has been extended beyond simple RV obstruction. Several studies highlighted the role of inflammation [ 15 ] and endothelial dysfunction [ 16 ] in the alteration of organ perfusion at the microcirculation level in the context of acute circulatory failure related to infection [ 17 ] or myocardial infarction. [ 18 ] In this study, we evaluated microcirculatory hypoperfusion parameters available at bedside and found these “easy to use and easy to learn” tools are helpful to identify high-risk patients in acute PE.…”

Section: Discussionmentioning

confidence: 99%

Tissue perfusion alterations correlate with mortality in patients admitted to the intensive care unit for acute pulmonary embolism

Urbina¹,

Bigé²,

Nguyen³

et al. 2018

Medicine

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Endothelial dysfunction in patients with pulmonary thromboembolism: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Cited by 34 publications

References 23 publications

The role of neutrophil‐to‐lymphocyte ratio in men with erectile dysfunction—preliminary findings of a real‐life cross‐sectional study

The role of neutrophil‐to‐lymphocyte ratio in men with erectile dysfunction—preliminary findings of a real‐life cross‐sectional study

Value of the platelet-to-lymphocyte ratio in the prediction of left ventricular thrombus in anterior ST-elevation myocardial infarction with left ventricular dysfunction

Tissue perfusion alterations correlate with mortality in patients admitted to the intensive care unit for acute pulmonary embolism

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