Endothelial dysfunction in patients with rheumatoid arthritis and comorbidity

Константиновна, Князева Антонина; Комарова, Е Б; Bludova, N.

doi:10.14412/1996-7012-2017-4-25-29

Cited by 3 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When duration of the disease is longer, VEGF content in the blood of patients increases. At the same time, it does not find age dependence with RA and did not change additionally with comorbid IHD [10]. Therefore, it is chronic inflammatory process with RA that becomes the major factor in detection of levels of this regulator protein.…”

Section: Discussionmentioning

confidence: 76%

“…Since it stimulates growth and migration of vascular endothelium cells for the formation of the basal lamina, it can influence on the processes of chronic inflammation promoting collagen deposits in the place of inflammation, remodeling the cartilaginous and osseous tissues, stimulating osteoclastogenesis, forming subchondral cysts and provoking RA and osteoporosis. Now VEGF present in the focus of inflammation is a possible marker of the blood plasma inducing synthesis of TNF-α and IL-1β, IL-6 by mononuclear leukocytes of the synovial fluid [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parameters of Endothelial Dysfunction and Immune Response in Patients With Rheumatoid Arthritis With and Without Ischemic Heart Disease

et al. 2022

View full text Add to dashboard Cite

The aim: To determine changes in endothelial dysfunction and immunological response in patients with rheumatoid arthritis with and without coronary heart disease. Materials and methods: The study involved 151 patients with RA and coronary heart disease. The ED was assessed by examining the NO system in RA for determination of the content in the blood of the product of NO synthase – the final metabolites of NO2– and NO3– and the level of VEGF and CD28 in the serum. Results: The results of the study of the levels of metabolites NO2– and NO3– in the first and second groups showed their increased content. Analysis of the content of VEGF in the blood for patients with different durations of the disease showed that the concentration of the studied protein grows larger with increasing duration of the disease. The maximum of sCD28 concentration was found in middle-aged patients, and the minimum (the difference was significant) – in the elderly. Conclusions: As the duration of the disease increases, the content of VEGF in the blood of patients increases, which, at the same time, did not show age dependence on RA and did not change further with concomitant coronary heart disease. Detected concentrations of sCD28 are higher in patients with less prolonged RA, and begin to decrease with increasing duration of the disease.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Parameters of Endothelial Dysfunction and Immune Response in Patients With Rheumatoid Arthritis With and Without Ischemic Heart Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This applies particularly to such diseases as acute/chronic rheumatic fever and rheumatoid arthritis. Late diagnosis of psychiatric disorders complicates the possibility of providing a qualified medical assistance for patients, adversely affecting the further rehabilitation, and impairs social consequences of rheumatic diseases [11][12][13][14]. The psy-chopathological study assessing this pathology is of great importance since mental disorders affect the psychological state of patients [15,16,[21][22][23][24].…”

mentioning

confidence: 99%

Psychocorrection of psychic and psychopathological disorders in rheumatologic pathology

Kozidubova

Doluda

Honcharov

et al. 2020

ZMJ

View full text Add to dashboard Cite

Ревматична патологія -одна з найбільш актуальних проблем сучасної медицини у зв'язку з впливом захворювань цієї групи на якість життя пацієнтів, оскільки призводить до інвалідизації.Мета роботи -розробити комплекс психокорекції порушень на підставі системного аналізу клініко-психопатологічних і патопсихологічних особливостей пацієнтів із ревматичною патологією.Матеріали та методи. Обстежили 124 особи, середній вік -39,5 року; 99 пацієнтів із ревматичною патологією включили в основну групу в період рандомізації. Перша група включала 48 пацієнтів із гострою/хронічною ревматичною лихоманкою (R), друга -51 пацієнт із ревматоїдним артритом (RA). У 25 пацієнтів із ревматичною патологією не виявили психічні розлади, тому вони не були рандомізовані. Клініко-психопатологічний метод використовували для виявлення різних рівнів психопатології відповідно до МКХ-10. Психодіагностичні методи застосовували для вивчення патопсихологічних характеристик пацієнтів: тест Люшера -для вивчення та оцінювання індивідуального й емоційного стану пацієнтів (Собчик Л., 2002); колірний тест відносин (КТВ) -для виявлення емоційних компонентів ставлення пацієнта до значущого оточення та самого себе (Бажин Е. Ф., Еткінд А. М., 1985); тест Кеттелла -для виявлення характеристик особистості (16 PF, форма A), шкала самооцінки Т. Дембо і С. Дж. Рубінштейна (Bleyher В. М., Крук І. В., 1986) -для оцінювання критичних навичок. Індивідуальні психокорекційні комплекси включали методи м'язової релаксації Якобсона та аутогенного тренування, техніки саморегуляції, навички емоційної релаксації, перемикання уваги.

show abstract

Features of dyslipidemia and its influence on endothelium functional state in patients with rheumatoid arthritis and arterial hypertension

Fushtey

Подсевахіна

Palamarchuk

et al. 2021

Modern Medical Technology

View full text Add to dashboard Cite

Purpose of the study. Was to identify the features of blood lipid spectrum and endothelium functional state in patients with rheumatoid arthritis (RA) and arterial hypertension (AH). Materials and methods. 83 patients were examined (40 with RA combined with AH, 23 with RA and 20 with AH). The blood lipid spectrum and endothelial function were studied in all patients. Results. The analysis of blood serum lipid parameters demonstrated that in patients with RA, regardless of the presence of AH, there was a significant increase of proatherogenic lipid profile parameters in comparison with those in healthy subjects. It was shown, that lower concentrations of high-density lipoproteins and higher atherogenic coefficient indices was a characteristic feature of the lipid profile in RA patients both with and without AH - in contrast to the same parameters of the lipid spectrum in patients with AH without RA. In the groups of patients with RA a significant increase of the brachial artery diameter at rest and decreased indices of endothelium-dependent vasodilation and endothelium-independent vasodilation were revealed. Subjects with RA in combination with AH had significantly lower indices according to the tests with both reactive hyperemia and nitroglycerin, while in patients with RA without AH, only NG-test was significantly lower. Conclusion. Dyslipidemia of atherogenic type and endothelial dysfunction develops at the initial stages of rheumatoid process and depends on the activity of the inflammatory process, the presence of extra-articular manifestations and rheumatoid factor seropositivity. Keywords: rheumatoid arthritis, arterial hypertension, dyslipidemia, endothelial dysfunction.

show abstract

Endothelial dysfunction in patients with rheumatoid arthritis and comorbidity

Cited by 3 publications

References 11 publications

Parameters of Endothelial Dysfunction and Immune Response in Patients With Rheumatoid Arthritis With and Without Ischemic Heart Disease

Parameters of Endothelial Dysfunction and Immune Response in Patients With Rheumatoid Arthritis With and Without Ischemic Heart Disease

Psychocorrection of psychic and psychopathological disorders in rheumatologic pathology

Features of dyslipidemia and its influence on endothelium functional state in patients with rheumatoid arthritis and arterial hypertension

Contact Info

Product

Resources

About