Endothelial dysfunction in subfertile women with polycystic ovary syndrome

Chen, Liang-Hsuan; Lin, Chia‐Pin; Wu, Hsien-Ming; Chu, Pao‐Hsien

doi:10.1016/j.rbmo.2022.11.013

Cited by 5 publications

(5 citation statements)

References 49 publications

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“…Maternal vascular endothelial dysfunction is a classic feature of PE that is thought to be secondary to reduced placental blood flow and the release of pro-inflammatory cytokines, reactive oxygen species, and extracellular vesicles, as well as the imbalance of angiogenic and anti-angiogenic factors [ 25 , 142 ]. Experimental studies have shown that women with PCOS exhibit endothelial dysfunction (impaired endothelium-dependent vasodilation) and reduced responses to the vasodilation effect of insulin [ 143 , 144 , 145 , 146 ]. The observed endothelial dysfunction may be related to both elevated androgen levels and IR [ 143 , 145 ].…”

Section: Mechanisms Of Action Of Nutritional Factors In the Pathophys...mentioning

confidence: 99%

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Parker,

O’Brien,

Yeoh

et al. 2024

JCM

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Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with a variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms and signs. Women with PCOS are at increased risk of pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labor, and pre-eclampsia (PE). This may be attributed to the presence of specific susceptibility features associated with PCOS before and during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), and hyperandrogenism, all of which have been associated with an increased risk of pregnancy complications. Many of the features of PCOS are reversible following lifestyle interventions such as diet and exercise, and pregnant women following a healthy lifestyle have been found to have a lower risk of complications, including PE. This narrative synthesis summarizes the evidence investigating the risk of PE and the role of nutritional factors in women with PCOS. The findings suggest that the beneficial aspects of lifestyle management of PCOS, as recommended in the evidence-based international guidelines, extend to improved pregnancy outcomes. Identifying high-risk women with PCOS will allow targeted interventions, early-pregnancy screening, and increased surveillance for PE. Women with PCOS should be included in risk assessment algorithms for PE.

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Section: Mechanisms Of Action Of Nutritional Factors In the Pathophys...mentioning

confidence: 99%

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Parker,

O’Brien,

Yeoh

et al. 2024

JCM

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show abstract

“…Similarities don't end there. PCOS is associated with endothelial dysfunction [384][385][386][387][388][389][390][391][392][393][394], IR [395][396][397][398][399][400], mitochondrial dysfunction [401][402][403][404][405][406], inflammation [407][408][409][410][411][412], elevated proinflammatory cytokines [413][414][415][416][417] and pathogenic immune system activation [418][419][420][421]. Women are often hyperlipidemic [422][423][424][425] and at heightened risk for type II diabetes and heart disease [426][427][428][429][430].…”

Section: Systemic Energy Deficitmentioning

confidence: 99%

Energy Dynamics in the Metabolic Syndrome: Underpinnings of an Evolving Global Catastrophe

Thorp,

Thorp

2024

G Med Sci

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In this article we describe the dynamic aspects of MetS and show the systemic nexus of derangements that occur in conjunction with insulin resistance (IR). But IR is not the primary problem and insulin, alas, is but an innocent bystander. In previous works we document the presence of an organized energy field taking origin in the blood through the contraction and dilation cycles of the heart. In the final analysis IR is secondary to a defect in the generation and availability of blood-borne energy. This is to say that all aspects of MetS and all ensuing states of organ dysfunction are manifestations of a progressing and cumulative energy deficit. On this basis it only stands to reason that all attempts at remediation must be aimed toward enhancing energy generation and flow in the blood.

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“…Maternal vascular endothelial dysfunction is a classic feature of PE that is thought to be secondary to reduced placental blood flow and release of pro-inflammatory cytokines, reactive oxygen species, extracellular vesicles, and imbalance of angiogenic and anti-angiogenic factors [39,137]. Experimental studies have shown that women with PCOS have endothelial dysfunction (impaired endothelium-dependent vasodilation) and reduced response to the vasodilation effect of insulin [138][139][140][141]. The observed endothelial dysfunction may be related to both elevated androgen levels and IR [138,140].…”

Section: Insulin Resistancementioning

confidence: 99%

Reducing the Risk of Pre-eclampsia in Women with Polycystic Ovary Syndrome using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Parker,

O'Brien,

Yeoh

et al. 2023

Preprint

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Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with a variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms and signs. Women with PCOS are at increased risk of pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labour, and preeclampsia (PE). This may be attributed to the presence of specific susceptibility features associated with PCOS before and during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), and hyperandrogenism, all of which have been associated with an increased risk of pregnancy complications. Many of the features of PCOS are reversible following lifestyle interventions such as diet and exercise, and pregnant women following a healthy lifestyle have been found to have a lower risk of complications, including PE. This review summarizes the evidence investigating the risk of PE and the role of nutritional factors in women with PCOS. The findings suggest that the beneficial aspects of lifestyle management of PCOS, as recommended in the evidenced-based international guidelines, extend to improved pregnancy outcomes. Identifying high-risk women with PCOS will allow targeted interventions, early pregnancy screening, and increased surveillance for PE. Women with PCOS should be included in risk assessment algorithms for PE.

show abstract

Endothelial dysfunction in subfertile women with polycystic ovary syndrome

Cited by 5 publications

References 49 publications

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Energy Dynamics in the Metabolic Syndrome: Underpinnings of an Evolving Global Catastrophe

Reducing the Risk of Pre-eclampsia in Women with Polycystic Ovary Syndrome using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

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