Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease – a cross-sectional study of predialysis, dialysis and kidney-transplantation patients

Recio-Mayoral, Alejandro; Banerjee, Debasish; Streather, Christopher P.; Kaski, Juan Carlos

doi:10.1016/j.atherosclerosis.2011.02.017

Cited by 205 publications

(178 citation statements)

References 22 publications

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“…Potential mediators between kidney function and endothelial function included ADMA and TNF-α [19]. Similar results were found by Recio-Mayoral et al [20] and Shukla et al [21] who observed that hemodialysis and CKD stage 4patients had reduced FMD values as compared to controls. Chong et al [19] found an inverse relationship between renal function and FMD in symptomatic peripheral arterial disease.…”

Section: Discussionsupporting

confidence: 77%

Relationship Between Asymmetric Dimethylarginine (ADMA) and Atherosclerosis in Chronic Renal Failure Patients

Rashed¹,

Soliman²,

Aun³

et al. 2017

J Nephrol Ther

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Section: Discussionsupporting

confidence: 77%

Relationship Between Asymmetric Dimethylarginine (ADMA) and Atherosclerosis in Chronic Renal Failure Patients

Rashed¹,

Soliman²,

Aun³

et al. 2017

J Nephrol Ther

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“…First, we investigated only the effect of baseline serum albumin and CRP levels at the time of entry into the study and changes in serum albumin over time have been demonstrated to predict mortality 30) . A recent study has shown that patients with ESRD have a higher inflammatory status with increased CRP associated with endothelial dysfunction and atherosclerosis 31) . Second, we did not assess different approaches to the detection of malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients

Amemiya

Ogawa

Otsuka

et al. 2011

JAT

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Aim:Although serum albumin and C-reactive protein (CRP) levels and pulse wave velocity (PWV) are known to be associated with the clinical outcome of hemodialysis (HD) patients, it is unknown which of these parameters are more predictive of the long-term mortality of such patients. Methods: We measured biochemical parameters, including serum albumin and CRP, and the PWV of 202 patients on maintenance HD therapy and followed their course for 4 years, and 186 of the patients were enrolled in the current study analyses. We divided the 186 patients into three tertiles according to their serum albumin and CRP levels and PWV values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality. Results: Twenty-three (12.4%) patients died during the follow-up period, and the serum albumin of the group that died was significantly lower than in the group that survived, but the CRP levels and PWV were significantly higher in the group that died. The results of Kaplan-Meier analyses revealed a significantly higher risk of all-cause mortality in HD patients with higher CRP based on the results of Cox proportional hazards analyses; however, the serum albumin and PWV values were not associated with all-cause mortality. Conclusion:The results of this study suggest that serum CRP levels are a better mortality predictor than serum albumin or PWV values of chronic HD patients.

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“…28) Increased hs-CRP level was an independent predictor of abnormal flow mediated dilation, which indicated systemic endothelial function, after adjusting for age, systolic and diastolic blood pressure, and total cholesterol. 29) Systemic endothelial cell dysfunction may contribute to arterial stiffness. 30) In the pre-DM patients in the present study, an increased HOMA index and increased hs-CRP level may result in systemic endothelial cell dysfunction, subsequently affecting arterial stiffness indices.…”

Section: Possible Mechanisms Of Increased Arterial Stiffness In Pre-dmmentioning

confidence: 99%

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

et al. 2013

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SummaryPremature arteriosclerosis may be one of the mechanisms linking pre-diabetes mellitus (pre-DM) and cardiovascular disease. We sought to characterize premature arteriosclerosis in pre-DM using different arterial stiffness indices and to fi nd the independent contributors of this process. We recruited 33 patients without DM, 53 patients with pre-DM, and 34 subjects with DM. Both the compliance index (CI) and stiffness index (SI) were measured. Patients with pre-DM and DM had lower CI (3.8 ± 2.1 versus 5.2 ± 3.0 units; P < 0.05 and 3.6 ± 1.8 versus 5.2 ± 3.0 units; P < 0.05, respectively) and higher SI (8.0 ± 2.0 versus 6.7 ± 1.6 m/s; P < 0.01 and 9.4 ± 2.3 versus 6.7 ± 1.6 m/s; P < 0.001, respectively) than patients without DM. Using multivariate linear regression analysis, age, heart rate, and HOMA index were independent determinants for SI (whole model: R 2 = 0.47, P < 0.001), whereas male gender, hsCRP, and HOMA index were independent determinants for CI (whole model: R 2 = 0.34, P < 0.01). The HOMA index was an independent determinant for arterial stiffness. Increased insulin resistance may associate with increased arterial stiffness at peripheral arteries in pre-DM patients. (Int Heart J 2013; 54: 27-32)

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Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease – a cross-sectional study of predialysis, dialysis and kidney-transplantation patients

Cited by 205 publications

References 22 publications

Relationship Between Asymmetric Dimethylarginine (ADMA) and Atherosclerosis in Chronic Renal Failure Patients

Relationship Between Asymmetric Dimethylarginine (ADMA) and Atherosclerosis in Chronic Renal Failure Patients

Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

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