Endothelial dysfunction influences augmented aortic hemodynamic responses to metaboreflex activation in postmenopausal women

Martinez, Mauricio A.; Dillon, Katherine N.; Kang, Yejin; Maharaj, Arun; Fischer, Stephen M.; Figueroa, Arturo

doi:10.1007/s00421-024-05476-5

Cited by 1 publication

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A greater increase in SBP during exercise in older women, compared to young women and men, and older men is due to an inability to attenuate vasoconstriction [ 55 ]. Postmenopausal women have exaggerated SBP responses to exercise due, in part, to endothelial dysfunction and increased sympathetic-mediated vasoconstriction [ 33 , 56 , 57 ]. Although several endothelial-derived and skeletal muscle-derived (ATP, adenosine, potassium) factors are involved in augmenting local BF, NO and prostaglandin are the main vasodilators during exercise.…”

Section: Discussionmentioning

confidence: 99%

L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women

Kang,

Dillon,

Martinez

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

Endothelial dysfunction decreases exercise limb blood flow (BF) and muscle oxygenation. Acute L-Citrulline supplementation (CIT) improves muscle tissue oxygen saturation index (TSI) and deoxygenated hemoglobin (HHb) during exercise. Although CIT improves endothelial function (flow-mediated dilation [FMD]) in hypertensive women, the impact of CIT on exercise BF and muscle oxygenation (TSI) and extraction (HHb) are unknown. We examined the effects of CIT (10 g/day) and a placebo for 4 weeks on blood pressure (BP), arterial vasodilation (FMD, BF, and vascular conductance [VC]), and forearm muscle oxygenation (TSI and HHb) at rest and during exercise in 22 hypertensive postmenopausal women. Compared to the placebo, CIT significantly (p < 0.05) increased FMD (Δ−0.7 ± 0.6% vs. Δ1.6 ± 0.7%) and reduced aortic systolic BP (Δ3 ± 5 vs. Δ−4 ± 6 mmHg) at rest and improved exercise BF (Δ17 ± 12 vs. Δ48 ± 16 mL/min), VC (Δ−21 ± 9 vs. Δ41 ± 14 mL/mmHg/min), TSI (Δ−0.84 ± 0.58% vs. Δ1.61 ± 0.46%), and HHb (Δ1.03 ± 0.69 vs. Δ−2.76 ± 0.77 μM). Exercise BF and VC were positively correlated with improved FMD and TSI during exercise (all p < 0.05). CIT improved exercise artery vasodilation and muscle oxygenation via increased endothelial function in hypertensive postmenopausal women.

show abstract