Endothelial dysfunction is associated with impaired lung function in two independent community cohorts

Rydell, Andreas; Janson, Christer; Lisspers, Karin; Ställberg, Björn; Nowak, Christoph; Carlsson, Axel C.; Feldreich, Tobias; Iggman, David; Lind, Lars; Ärnlöv, Johan

doi:10.1016/j.rmed.2018.09.009

Cited by 5 publications

(2 citation statements)

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“…These findings indicate that endothelial function contributes to CBF regulation. On the other hand, endothelial function is impaired by respiratory dysfunction (63). Moreover, previous study (9) demonstrated that endothelial dysfunction of the cerebral vasculature is related to increase in oxidative stress.…”

Section: Reactive Oxygen Species and Endothelial Functionmentioning

confidence: 98%

Interaction between the respiratory system and cerebral blood flow regulation

Ogoh

2019

Journal of Applied Physiology

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This review summarizes the interaction between the regulatory system of respiration and cerebral vasculature. Some clinical reports provide evidence for the association between these two physiological regulatory systems. Physiologically, arterial carbon dioxide concentration is mainly regulated by two feedback control systems: respiration and cerebral blood flow. In other words, both of these systems are sensitive to the same mediator, i.e., carbon dioxide, at a set point. In addition, respiratory dysfunction alters various physiological factors that affect the cerebral vasculature. Therefore, it is physiologically plausible that these systems are closely linked. The regulation of arterial carbon dioxide concentration affected by respiration and cerebral blood flow may be a key factor for a rise in the risk of brain disease in the patients with respiratory dysfunction. For example, the management of respiratory disease (e.g., patients with chronic obstructive pulmonary disease) and the use of prophylactic therapy are essential to reduce the risk of stroke.

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Section: Reactive Oxygen Species and Endothelial Functionmentioning

confidence: 98%

Interaction between the respiratory system and cerebral blood flow regulation

Ogoh

2019

Journal of Applied Physiology

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“…Moreover, it is important to explore factors common to lung function and atherosclerosis to prevent CVD. dysfunction, and cIMT [52][53][54] . Therefore, although arterial stiffness and endothelial dysfunction may be confounding factors for the association between lung function and cIMT, we could not consider them because we did not collect information on them.…”

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study

Takase

Yamada

Nakamura

et al. 2023

JAT

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Aim: Impaired lung function is associated with atherosclerotic vascular events. Carotid intima-media thickness (cIMT) is a marker for subclinical atherosclerosis. However, few studies have examined the association between lung function and cIMT among never smokers or individuals stratified by age. We investigated the association between lung function and cIMT in the Japanese population. Methods:We conducted a cross-sectional study of 3,716 men and 8,765 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was evaluated using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) was measured using spirometry. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between lung function and cIMT and adjusted for potential confounders. A linear trend test was conducted by scoring the categories from 1 (lowest) to 4 (highest) and entering the score as a continuous term in the regression model.Results: After adjusting for potential confounders including passive smoking, lower FEV1 and FVC were associated with higher cIMT in both men and women (P＜0.001 for linear trend). This association was confirmed even when we restricted our study to never smokers. Furthermore, even when we stratified by age, an inverse association between lung function and cIMT was confirmed in middle-aged (40-64 years) and elderly participants (65-74 years).Conclusions: Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.

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Plasma proteomics and lung function in four community-based cohorts

Rydell

Nowak

Janson

et al. 2021

Respiratory Medicine

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Background: Underlying mechanism leading to impaired lung function are incompletely understood. Objectives: To investigate whether protein profiling can provide novel insights into mechanisms leading to impaired lung function. Methods: We used four community-based studies (n = 2552) to investigate associations between 79 cardiovascular/inflammatory proteins and forced expiratory volume in 1 s percent predicted (FEV 1 %) assessed by spirometry. We divided the cohorts into discovery and replication samples and used risk factor-adjusted linear regression corrected for multiple comparison (false discovery rate of 5%). We performed Mendelian randomization analyses using genetic and spirometry data from the UK Biobank (n = 421,986) to assess causality. Measurements and main results: In cross-sectional analysis, 22 proteins were associated with lower FEV 1 % in both the discovery and replication sample, regardless of stratification by smoking status. The combined proteomic data cumulatively explained 5% of the variation in FEV 1 %. In longitudinal analyses (n = 681), higher plasma levels of growth differentiation factor 15 (GDF-15) and interleukin 6 (IL-6) predicted a more rapid 5-year decline in lung function (change in FEV 1 % per standard deviation of protein level − 1.4, (95% CI, − 2.5 to − 0.3) for GDF-15, and -0.8, (95% CI, − 1.5 to − 0.2) for IL-6. Mendelian randomization analysis in UK-biobank provided support for a causal effect of increased GDF-15 levels and reduced FEV 1 %. Conclusions: Our combined approach identified GDF-15 as a potential causal factor in the development of impaired lung function in the general population. These findings encourage additional studies evaluating the role of GDF-15 as a causal factor for impaired lung function.

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Endothelial dysfunction is associated with impaired lung function in two independent community cohorts

Abstract: Our findings suggest that even individuals with sub-clinical impairments of lung function in the community have concomitant endothelial dysfunction.

Cited by 5 publications

References 40 publications

Interaction between the respiratory system and cerebral blood flow regulation

Interaction between the respiratory system and cerebral blood flow regulation

The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study

Plasma proteomics and lung function in four community-based cohorts

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