Endothelial Dysfunction Is Reversible in Helicobacter Pylori-Positive Subjects

Blum, Arnon; Tamir, Snait; Mualem, Keren; Ben-Shushan, Rotem Shelly; Keinan‐Boker, Lital; Paritsky, Maya

doi:10.1016/j.amjmed.2011.08.015

Cited by 37 publications

(32 citation statements)

References 22 publications

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“…Measurement of the FMD in the brachial artery using high-resolution ultrasound has been widely adopted as a method to assess the endothelial function 55,56) . Furthermore, the endothelial dysfunction noted in H. pylori-positive subjects improves after H. pylori eradication 57) . There are several possible mechanisms underlying the potential causative role of H. pylori in endothelial dysfunction.…”

Section: Potential Mechanisms Through Which H Pylori May Contribute mentioning

confidence: 99%

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Yang

Lü

2014

JAT

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Accumulating evidence implicates Helicobacter pylori (H. pylori) infection in the pathogenesis of certain diseases localized outside the stomach, particularly those characterized by persistent and lowgrade systematic inflammation. Recently, the role of H. pylori infection in the development of atherosclerosis and its clinical complications has received attention. Atherosclerosis is a high-cost disease, and acute events resulting from this condition rank first among morbidity and mortality statistics in most industrialized countries. Atherosclerosis is a multifactorial disorder, and traditional risk factors explain only 50% of its etiology. Therefore, identifying new risk factors for atherosclerosis is necessary. Serological studies indicate that chronic H. pylori infection, especially that with more virulent strains, may predispose patients to the onset of atherosclerosis and related adverse clinical events, and PCR studies have detected H. pylori DNA in atherosclerotic plaques, although this finding remains controversial. If this association were to be confirmed, its importance to public health would be substantial, as the eradication of H. pylori is more straightforward and less costly than the longterm treatment of other risk factors. This review investigates the potential relationship between H. pylori infection and atherosclerosis from both epidemiological and pathogenic perspectives and characterizes the potential mechanisms underlying this correlation.

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Section: Potential Mechanisms Through Which H Pylori May Contribute mentioning

confidence: 99%

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Yang

Lü

2014

JAT

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“…Due to lack of similar studies, we could not compare the results of this study with other findings. Blum and colleagues reported that H. pylori eradication could improve endothelial dysfunction according to attenuated FMD and ankle brachial index after 3 months (3) . This study also revealed a reverse correlation between FMD changes and the serum level of IgG as a serological marker of H. pylori infection, for the first time.…”

Section: Relationship Between Igg Level With Markers Of Endothelial Dmentioning

confidence: 99%

Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

Judaki

Norozi

Ahmadi

et al. 2017

Arq. Gastroenterol.

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“…[57818] In addition, H. pylori may have a role in promoting atherosclerosis by modifying lipid metabolism by elevating lowdensitylipoproteinand decreasing high density lipoprotein (HDL). [1927414243] H. pylori positive subjects have severe endothelial dysfunction which predisposes them to atherosclerosis. [1926]…”

Section: Discussionmentioning

confidence: 99%

“…[1927414243] H. pylori positive subjects have severe endothelial dysfunction which predisposes them to atherosclerosis. [1926]…”

Section: Discussionmentioning

confidence: 99%

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No detection of Helicobacter pylori in atherosclerotic plaques in end stage renal disease patients undergoing kidney transplantation

et al. 2013

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Chronic infection known to be a predisposing factor for the development of atherosclerosis. Several studies have found a possible role of Helicobacter pylori in the pathogenesis of atherosclerosis. The aim of this study was to investigate the presence of H. pylori in atherosclerotic plaques in iliac arteries in 25 end stage renal disease (ESRD) patients undergoing kidney transplantation. Esophagogastroduodenoscopy was performed in all patients before transplantation. Biopsy specimens obtained from gastric antrum were sent for pathologic evaluation. Gastric H. pylori infection was confirmed by microscopic assessment and rapid urease test. Arterial specimens were obtained from iliac arteries during kidney transplantation. Presence of H. pylori DNA in atherosclerotic plaques and healthy vessel samples was evaluated by the polymerase chain reaction (PCR). The mean age of patients was 44.1 ± 22.6 years. Risk factors in patients with atherosclerosis were hypertension (68%), diabetes mellitus (20%), hyperlipidemia (20%), positive family history (16%). Atherosclerotic plaques were found in 21 (84%) patients. PCR analysis did not detect H. pylori in any case. There was a significant relationship of atherosclerosis with hypertension (P = 0.006) but not with diabetes mellitus and hyperlipidemia (P = 0.5). There was no significant relationship between atherosclerosis and gastric H. pylori infection (P = 0.6). This study revealed no association between the presence of H. pylori as a pathogen of vessel walls and atherosclerosis in ESRD.

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Endothelial Dysfunction Is Reversible in Helicobacter Pylori-Positive Subjects

Cited by 37 publications

References 22 publications

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Flow Mediated Dilation and Carotid Intima Media Thickness in Patients With Chronic Gastritis Associated With Helicobacter Pylori Infection

No detection of Helicobacter pylori in atherosclerotic plaques in end stage renal disease patients undergoing kidney transplantation

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