Endothelial dysfunction, left ventricular diastolic dysfunction and the Systematic Coronary Risk Evaluation2 algorithm – a cross-sectional study

Sušić, Livija; Maričić, Lana; Klobučar, Lucija; Šahinović, Ines; Kralik, Kristina; Sušić, Tihomir; Vincelj, Josip

doi:10.15836/ccar2022.256

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…In recent years, the potential role of ADMA in the development of CVD has attracted considerable attention of researchers. Due to the data of numerous studies, an increased level of ADMA in blood plasma was seen in patients with a combination of CHD with hypercholesterolemia, hypertension, diabetes mellitus (DM) type 2 and insulin resistance, hypertriglyceridemia, hyperhomocysteinemia [5,6,7]. Distinct attention is paid to the close relationship between CHD and the pathology of the hepatobiliary system, primarily with non-alcoholic fatty liver disease (NAFLD) [8,9].…”

Section: клінічна та експериментальна медицина / Clinical and Experim...mentioning

confidence: 99%

Features of the Functional State of the Liver and Indicators of Endothelial Dysfunction in Patients With Coronary Heart Disease Combined With Non-Alcoholic Fatty Liver Disease

Ihnatko,

Derbak,

Chubirko

et al. 2024

VPBM

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Вісник проблем біології і медицини -2024 -Вип. 1 (172) / Bulletin of problems in biology and medicine -2024 -Issue 1 (172) 156 КЛІНІЧНА ТА ЕКСПЕРИМЕНТАЛЬНА МЕДИЦИНА / CLINICAL AND EXPERIMENTAL MEDICINE of Baku. During the seven-year study period (2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020), 559 patients were diagnosed with MS. Of these, 392 (70.1%) patients were female and 167 (29.9%) were male. At the same time, in 390 (69.9%) patients the disease had recurrent (RMS), 109 (19.5%) had progressive (PMS) types of course, and 60 (10.6%) had a clinically isolated syndrome (CIS). CIS was more common in the age group of 20-29 years, RMS in the group of 30-39 years, and PMS was typical in the groups of 40-49 and 50-59 years. The manifestation of the disease in the CIS and RMS groups began at almost the same age (26.0 (24.0-34.0) and 27.0 (22.0-34.0)), with clinical manifestations of damage in one functional system, with a statistically significant difference in age with PRS (34.0 (25.0-41.0)), where the catastrophe was observed in several functional systems. Atrophic changes on MRI of the brain predominated in the group of patients with PMS type of course from the first symptoms of the disease (21.1% of cases), and with subsequent visualizations it tended to increase, reaching 57.4%. In patients treated with a drug that modifies the course of MS -beta interferon 1a, by the end of the year of treatment, EDSS in the CIS and PMS groups remained stable (3.0 (2.0-4.0) and 4.25 (4.0-5.5), respectively), while in the RMS group there was a statistically significant improvement in clinical condition (2.0 (1.0-4.0)).

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Section: клінічна та експериментальна медицина / Clinical and Experim...mentioning

confidence: 99%

Features of the Functional State of the Liver and Indicators of Endothelial Dysfunction in Patients With Coronary Heart Disease Combined With Non-Alcoholic Fatty Liver Disease

Ihnatko,

Derbak,

Chubirko

et al. 2024

VPBM

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“…Given that SCORE2 does not cover all known CV risk factors, some patients remain underestimated; so in recent decades, scientists have been focused on researching the molecular connection between CV risk factors, CVDs, CHD, and HF. The universal pathophysiological change that connects all entities is endothelial dysfunction (ED) [10]. ED is a disorder responsible for reducing the bioavailability of nitric oxide (NO), which leads to the development of atherosclerosis directly and, via the NO-soluble guanylate cyclase-protein kinase G (sGC-PKG) signaling pathway, to disturbed cardiomyocyte remodeling indirectly [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study

Sušić

Maričić

Šahinović

et al. 2023

IJERPH

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Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication (p < 0.001). They also had significantly lowest plasma ADMA values (p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations (p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects.

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Endothelial dysfunction, left ventricular diastolic dysfunction and the Systematic Coronary Risk Evaluation2 algorithm – a cross-sectional study

Cited by 2 publications

References 2 publications

Features of the Functional State of the Liver and Indicators of Endothelial Dysfunction in Patients With Coronary Heart Disease Combined With Non-Alcoholic Fatty Liver Disease

Features of the Functional State of the Liver and Indicators of Endothelial Dysfunction in Patients With Coronary Heart Disease Combined With Non-Alcoholic Fatty Liver Disease

The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study

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