Endothelial dysfunction predicted cardiovascular events in patients with paroxysmal atrial fibrillation

Zhang, Jing; Tan, Qiang; Wang, Lina; Zhaoqian, Zhang

doi:10.15537/smj.2022.43.7.20220214

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…In another prospective observational study, FMD was measured by ultrasound in 291 patients with a positive history of PAF lasting no longer than six months. After a mean follow up of 33 months, subjects with FMD lower than 5.9% showed a doubled rate of composite adverse CV events, which included cardiovascular death, non-fatal myocardial infarction, stroke and heart failure hospitalization (37.1% versus 18% in patients with FMD > 5.9%, p < 0.001), which remained significant after adjustment for classical CV risk factors (HR: 3.036, 95%CI 1.546–5.963, p = 0.01) [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions—A Review from the VascAgeNet COST Action

Pucci,

Grillo,

Dalakleidi

et al. 2024

JCM

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Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with adverse CV outcomes. Vascular aging (VA), which is defined as the progressive deterioration of arterial function and structure over a lifetime, is an independent predictor of both AF development and CV events. A timing identification and treatment of early VA has therefore the potential to reduce the risk of AF incidence and related CV events. A network of scientists and clinicians from the COST Action VascAgeNet identified five clinically and methodologically relevant questions regarding the relationship between AF and VA and conducted a narrative review of the literature to find potential answers. These are: (1) Are VA biomarkers associated with AF? (2) Does early VA predict AF occurrence better than chronological aging? (3) Is early VA a risk enhancer for the occurrence of CV events in AF patients? (4) Are devices measuring VA suitable to perform subclinical AF detection? (5) Does atrial-fibrillation-related rhythm irregularity have a negative impact on the measurement of vascular age? Results showed that VA is a powerful and independent predictor of AF incidence, however, its role as risk modifier for the occurrence of CV events in patients with AF is debatable. Limited and inconclusive data exist regarding the reliability of VA measurement in the presence of rhythm irregularities associated with AF. To date, no device is equipped with tools capable of detecting AF during VA measurements. This represents a missed opportunity to effectively perform CV prevention in people at high risk. Further advances are needed to fill knowledge gaps in this field.

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Section: Resultsmentioning

confidence: 99%

Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions—A Review from the VascAgeNet COST Action

Pucci,

Grillo,

Dalakleidi

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Endothelial function is crucial for physiological activities. Patients with AF exhibit significantly reduced endothelial function compared to those with normal sinus rhythm, which is associated with adverse cardiovascular outcomes ( 28 , 29 ). Moreover, AF triggers the elevation of c-reactive protein and cytokines, exerting a proinflammatory effect on endothelial cells, potentially leading to endothelial dysfunction ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Factors influencing early recurrence of atrial fibrillation among elderly patients following radiofrequency catheter ablation and the impact of different antiarrhythmic regimens

Fei,

Zhao,

et al. 2024

Front. Med.

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BackgroundPatients with atrial fibrillation (AF) who undergo radiofrequency catheter ablation (RFCA) necessitate the administration of antiarrhythmic drugs to prevent early recurrence. The clinical outcomes among these patients may be influenced by varying antiarrhythmic regimens.ObjectivesTo identify the risk factors associated with early recurrence and compare the clinical outcomes among different antiarrhythmic regimens in elderly patients with AF following radiofrequency catheter ablation (RFCA) during a 3-month period.MethodsA retrospective observational study encompassed 420 elderly patients with AF following RFCA. Baseline data were collected during the initial postoperative visit and clinical outcomes were carefully monitored over a 3-month follow-up period. Logistic regression and Cox-proportional hazard regression analyses were performed to investigate the relationship between various antiarrhythmic regimens and the clinical outcomes.ResultsMultivariate logistic regression analysis revealed that age (p = 0.001), left atrial diameter (p < 0.001), left ventricular diameter (p = 0.015), reactive hyperemia index (RHI) (p < 0.001), antiarrhythmic drug (p < 0.001) and hs-cTnI (p = 0.017) were independent risk factors of early recurrence. Furthermore, in cox survival regression analysis model, survival rate of early recurrence in the amiodarone group was higher than in the propafenone group (HR 2.30, 95%CI 1.17–4.53, p = 0.016) and in the sotalol group (HR 3.60, 95%CI 2.17–5.95, p < 0.001). Compared to the amiodarone group, the incidence of liver dysfunction was lower in the dronedarone group (p = 0.046) and the propafenone group (p = 0.021). The incidence of bradyarrhythmia (p = 0.003), QT interval prolongation (p = 0.035) and atrioventricular transmission block (p = 0.021) were higher in the sotalol group than in the amiodarone group.ConclusionRHI was identified as an independent risk factor for early recurrence among elderly AF patients after RFCA. Compared to amiodarone, propafenone and sotalol exhibited an elevated risk of early recurrence. Although there was no significant difference in early recurrence between amiodarone and dronedarone, dronedarone emerged as the preferred option due to its lower frequency of adverse drug reactions than amiodarone.

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Subclinical Hypothyroidism Predicted Adverse Cardiovascular Events in Patients with Ejection Fraction Preserved Heart Failure

Tan,

Chen,

Yang

et al. 2024

TCRM

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Endothelial dysfunction predicted cardiovascular events in patients with paroxysmal atrial fibrillation

Cited by 3 publications

References 17 publications

Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions—A Review from the VascAgeNet COST Action

Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions—A Review from the VascAgeNet COST Action

Factors influencing early recurrence of atrial fibrillation among elderly patients following radiofrequency catheter ablation and the impact of different antiarrhythmic regimens

Subclinical Hypothyroidism Predicted Adverse Cardiovascular Events in Patients with Ejection Fraction Preserved Heart Failure

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