Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension*

Brunner, Hanspeter; Cockcroft, John R.; Deanfield, John; Donald, Ann; Ferrannini, Ele; Halcox, Julian; Kiowski, Wolfgang; Lüscher, Thomas F.; Mancia, Giuseppe; Natali, Andrea; Oliver, James; Pessina, Achille C.; Rizzoni, Damiano; Rossi, Gian Paolo; Salvetti, Antonio; Spieker, Lukas E.; Taddei, Stefano; Webb, David J.

doi:10.1097/00004872-200502000-00001

Cited by 694 publications

(558 citation statements)

References 161 publications

(125 reference statements)

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“…The mechanisms other than elevated BP, including endothelial dysfunction and arterial stiffness, are both involved in the pathogenesis of vascular disease. 7,35 Earlier, we have found that impaired endothelial function is associated with increased arterial stiffness. 13,14 Large artery stiffness causes a premature return of reflected waves in late systole, leading to increase in central pulse pressure, and thus systolic BP and load on the ventricle and oxygen demand.…”

Section: Discussionmentioning

confidence: 97%

“…1,[7][8][9][10] We and others showed that endothelial function is involved in the regulation of arterial elasticity. [11][12][13][14] Our previous study, using brachial-ankle pulse wave velocity (baPWV) for artery elasticity and circulating endothelial microparticles (EMPs, defined as CD31 þ /CD42À MPs) for endothelial function assessment showed that the level of circulating EMPs was highly closed to baPWV in well-functional healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

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Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients

Wang

et al. 2008

J Hum Hypertens

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Vascular dysfunction in hypertensive condition is characterized by impaired endothelial function and reduced artery elasticity. Circulating endothelial microparticles (EMPs) and brachial-ankle pulse wave velocity (baPWV) are novel evaluation parameters for vascular function. However, their changes in patients with well-controlled blood pressure (BP) have not been fully acquired. To address this issue, circulating EMPs, defined as CD31 þ /CD42À MPs and baPWV were detected in 30 healthy subjects, 30 uncontrolled hypertensive (UCHT) patients and 23 well-controlled hypertensive (WCHT) patients. UCHT patients displayed elevated baPWV (Po0.01) and circulating EMPs (Po0.01) compared with healthy subjects. In WCHT patients, vascular damage represented by these two parameters constantly existed (Po0.01). Values of circulating EMPs were positively related to baPWV (Po0.01). Multivariate regression defined circulating EMPs as an independent contributor to the increase of baPWV value (Po0.05). Our study indicated that though BP was controlled, impaired endothelial function and arterial elasticity continued. The optimal therapy for patients with hypertension should include not only lowering BP but also improvement of vascular injury in parallel.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients

Wang

et al. 2008

J Hum Hypertens

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“…Indeed, vascular aging is an independent risk factor of cardiovascular diseases that impair vascular health (Lakatta & Levy, 2003) and is now recognized as a target for intervention to achieve a healthier old age (Wang & Bennett, 2012). For that reason, understanding of the significance of age‐associated changes in the vascular endothelium is essential for the development of a therapeutic strategy to maintain vascular integrity (Brunner et al ., 2005). …”

Section: Introductionmentioning

confidence: 99%

Age‐associated downregulation of vasohibin‐1 in vascular endothelial cells

2016

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SummaryVasohibin‐1 (VASH1) is an angiogenesis‐inhibiting factor synthesized by endothelial cells (ECs) and it also functions to increase stress tolerance of ECs, which function is critical for the maintenance of vascular integrity. Here, we examined whether the expression of VASH1 would be affected by aging. We passaged human umbilical vein endothelial cells (HUVECs) and observed that VASH1 was downregulated in old HUVECs. This decrease in VASH1 expression with aging was confirmed in mice. To explore the mechanism of this downregulation, we compared the expression of microRNAs between old and young HUVECs by performing microarray analysis. Among the top 20 microRNAs that were expressed at a higher level in old HUVECs, the third highest microRNA, namely miR‐22‐3p, had its binding site on the 3′ UTR of VASH1 mRNA. Experiments with microRNA mimic and anti‐miR revealed that miR‐22‐3p was involved at least in part in the downregulation of VASH1 in ECs during replicative senescence. We then clarified the significance of this defective expression of VASH1 in the vasculature. When a cuff was placed around the femoral arteries of wild‐type mice and VASH1‐null mice, neointimal formation was augmented in the VASH1‐null mice accompanied by an increase in adventitial angiogenesis, macrophage accumulation in the adventitia, and medial/neointimal proliferating cells. These results indicate that in replicative senescence, the downregulation of VASH1 expression in ECs was caused, at least in part, by the alteration of microRNA expression. Such downregulation of VASH1 might be involved in the acceleration of age‐associated vascular diseases.

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“…[8][9][10] This could be attributed to the fact that both CAD and ED are characterized by endothelial dysfunction and injury. 11,12 These shared risk factors contribute to endothelial dysfunction and impede vasodilatation, thereby inhibiting the occurrence of normal erection.…”

Section: Introductionmentioning

confidence: 99%

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Chu

et al. 2009

Int J Impot Res

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We determined the association between the severity of erectile dysfunction (ED) and traditional cardiovascular risk factors, including metabolic syndrome (MS). A total of 141 ED patients were divided into three groups on the basis of ED severity, which was determined using the International Index of Erectile Function (IIEF) scores. The prevalence of MS among the ED patients was 32.6%. Significantly lower IIEF scores were noted in patients with MS than in patients without MS (7.6±6.4 vs 11.6±7.4, P ¼ 0.003). As assessed by the anthropometric indices of body mass index, waist circumference and waist-to-hip ratio, obesity was detected in 58.9, 54.6 and 32.6% of the patients, respectively. Of the 141 patients, 39 had mild, 24 had moderate and 78 had severe ED. Statistically significant differences were noted among the different ED severity groups with regard to the presence of hypertension, systolic blood pressure, presence of MS and number of MS components. Multivariate analysis showed that the odds ratio for high-low-density lipoprotein (LDL) cholesterol level in moderate and severe ED, determined with reference to mild ED, were 9.346 and 6.452, respectively. The presence of MS, number of MS components, and certain traditional cardiovascular risk factors, particularly high-LDL cholesterol level and hypertension, may influence the severity of ED.

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Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension*

Cited by 694 publications

References 161 publications

Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients

Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients

Age‐associated downregulation of vasohibin‐1 in vascular endothelial cells

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

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