Endothelial iNOS versus platelet iNOS: Responsibility for the platelet/leukocyte endothelial cell interaction in murine antigen induced arthritis in vivo

Schmitt‐Sody, Marcus; Gottschalk, Oliver; Metz, P; Zysk, S.; Hausdorf, Jörg; Pellengahr, Christoph von Schulze; Veihelmann, A.; Jansson, Volkmar

doi:10.1007/s00011-007-6171-x

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…In antigen-induced arthritis (AiA) mouse, Andreas et al found that the development of AIA is related to the overexpression of iNOS in synovial microcirculation of knee joint, the elevated NO production and the increased leukocyte adhesion/infiltration in synovium (Veihelmann et al, 2001). Meantime, in the C57/Bl6 mice with AIA, the iNOS expresses, after stimulation, up to ten times more NO than the two constitutive forms of NOS (Schmitt-Sody et al, 2007). When detailed mechanisms are explored, researchers found that the activation of NF-κB in multiple arthritis models including RA, CIA and AIA is necessary for both the initiation and development of inflammation (Makarov, 2001).…”

Section: Nitric Oxide Synthase (Nos) and Nitric Oxide (No)mentioning

confidence: 99%

Research Progress of Therapeutic Enzymes and Their Derivatives: Based on Herbal Medicinal Products in Rheumatoid Arthritis

Cai

Han

et al. 2021

Front. Pharmacol.

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Rheumatoid arthritis (RA) acts as one of the most common, agnogenic and chronic inflammatory-autoimmune disorder which is characterized by persistent synovitis, cartilage destruction, and joint deformities, leads to a wide range of disabilities, and increased mortality, thus imposing enormous burdens. Several drugs with anti-inflammatory and immunomodulatory properties such as celecoxib, diclofenac and methotrexate are being selected as conventional drugs in the allopathic system of medicine for the treatment of RA in clinic. However, there are some serious side effects more or less when using these drugs because of their short poor bioavailability and biological half-life for a long time. These shortcomings greatly promote the exploration and application of new low- or no-toxicity drugs for treating the RA. Meanwhile, a growing number of studies demonstrate that several herbs present certain anti-inflammatory and anti-arthritic activities through different enzymes and their derivatives, which indicate that they are promising therapeutic strategies when targeting these mediators based on herbal medicinal products in RA research. This review article summarizes the roles of the main enzymes and their derivatives during the pathogenesis of RA, and clearly clarifies the explicit and potential targeted actions of herbal medicinal products that have anti-RA activity. Our review provides timely and critical reference for the scientific rationale use of herbal medicinal products, with the increasing basic research and clinical application of herbal medicinal products by patients with RA.

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Section: Nitric Oxide Synthase (Nos) and Nitric Oxide (No)mentioning

confidence: 99%

Research Progress of Therapeutic Enzymes and Their Derivatives: Based on Herbal Medicinal Products in Rheumatoid Arthritis

Cai

Han

et al. 2021

Front. Pharmacol.

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“…The model we used in our study has been used previously to evaluate anti-inflammatory effects (37)(38)(39)(40). Therefore, we concluded that this model would be the best choice for this research project.…”

Section: Discussionmentioning

confidence: 97%

Therapeutic effect of methotrexate encapsulated in cationic liposomes (EndoMTX) in comparison to free methotrexate in an antigen-induced arthritis study in vivo

Gottschalk

Metz

Trong

et al. 2015

Scandinavian Journal of Rheumatology

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“…Thrombotic inflammatory cells may have a role in this process. Besides monocytes, other cells may express iNOS, such as platelets and VSMCs (Schmitt‐Sody et al. 2007).…”

Section: Discussionmentioning

confidence: 99%

Can eccentric arterial plaques alone cause flow stagnation points and favour thrombus incorporation?

Beneli¹,

Barbosa²,

Floriano³

et al. 2009

Int J Experimental Path

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We have used an experimental model of aorta stenosis, with a Plexiglas plug, simulating a stable atheromatous plaque that promotes local turbulence and thrombosis. With animal survival of more than 24 h, we followed the partial fibrinolysis of the thrombus as well as its posterior organization and incorporation to the arterial wall as a neointima for up to 30 days. The mushroom plug form permitted the development of recirculation and stasis areas around it, favouring this evolution. Despite noted limitations, this study demonstrates that thrombus incorporation can contribute to plaque extension, as it can promote recirculation and stasis areas.

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Endothelial iNOS versus platelet iNOS: Responsibility for the platelet/leukocyte endothelial cell interaction in murine antigen induced arthritis in vivo

Cited by 7 publications

References 38 publications

Research Progress of Therapeutic Enzymes and Their Derivatives: Based on Herbal Medicinal Products in Rheumatoid Arthritis

Research Progress of Therapeutic Enzymes and Their Derivatives: Based on Herbal Medicinal Products in Rheumatoid Arthritis

Therapeutic effect of methotrexate encapsulated in cationic liposomes (EndoMTX) in comparison to free methotrexate in an antigen-induced arthritis study in vivo

Can eccentric arterial plaques alone cause flow stagnation points and favour thrombus incorporation?

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