Endothelial keratoplasty: DSEK/DSAEK or DMEK - the thinner the better?

Dapena, Isabel; Ham, Lisanne; Melles, Gerrit R.J.

doi:10.1097/icu.0b013e32832b8d18

Cited by 260 publications

(202 citation statements)

References 80 publications

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“…The development in surgical treatment of corneal endothelial diseases, with progressive thinning of grafts and its related advantages (13,14) , leads us to conclude that transplantation with cultured en- dothelial cells may represent the next advance in this field (2)(3)(4)(5)(6)(7)(8)(9) . Animal studies have demonstrated promising results (15,16) .…”

Section: Discussionmentioning

confidence: 99%

Characterization of cryopreserved primary human corneal endothelial cells cultured in human serum-supplemented media

Vianna¹,

Li²,

Holiman

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Section: Discussionmentioning

confidence: 99%

Characterization of cryopreserved primary human corneal endothelial cells cultured in human serum-supplemented media

Vianna¹,

Li²,

Holiman

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…12,13 As duas formas de uso de corticosteroide intravítreo são injeção e implante de liberação lenta. O quadro 1 resume as principais características dos corticosteroides intravítreos.…”

Section: Diretrizesunclassified

Uveítes: diretrizes terapêuticas

Biancardi

Lani²,

Moraes

2015

e-oftalmo

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RESUMOEsta publicação tem como objetivo estabelecer diretrizes baseadas em evidências científicas para tratamento da uveíte. A necessidade de normatização de condutas em uveítes foi a principal motivação para o Conselho Brasileiro de Oftalmologia, em parceria com a Associação Médica Brasileira e Sociedade Brasileira de Uveíte, promover a elaboração das diretrizes. Foi realizada busca de evidência na base de informação científica Medline / Pubmed até agosto de 2015 para abordar as indicações de injeções / implantes intravítreos e uso de imunossupressores em uveítes. ABSTRACTThe objective of this study was to establish evidence-based guidelines for the treatment of uveitis. The Brazilian Council of Ophthalmology, in partnership with the Brazilian Medical Association and the Brazilian Society of Uveitis, has created guidelines to standardize the procedures for the treatment of uveitis. We searched the Medline and Pubmed databases dated until August 2015 to find indications of intravitreal injections/implants and the use of immunosuppressants for the treatment of uveitis. RESUMENEsta publicación tiene como objetivo establecer las directrices basadas en la evidencia científica para el tratamiento de la uveítis. La necesidad de una regulación de las tuberías en la uveítis fue la motivación principal para el Consejo Brasileño de Oftalmología, en colaboración con la Asociación Médica Brasileña y la Sociedad Brasileña de uveítis, promoviendo el desarrollo de las directrices. Búsqueda de pruebas se llevó a cabo en la base de información científica Medline / Pubmed hasta agosto de 2015 para hacer frente a los signos de inyecciones intravítreas / implantes y el uso de la terapia inmunosupresora en uveítis.Como citar: Biancardini AL, Lani A, Moraes Jr HV. Uveítes: diretrizes terapêuticas. e-Oftalmo.CBO: Rev Dig Oftalmol. 2015;1(4):01-07.

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“…1,2 Currently, descemet stripping automated endothelial keratoplasty (DSAEK) is the most popular form of endothelial keratoplasty (EK). EK has been associated with quicker visual recovery, less postoperative astigmatism, reduced risk of infection and better wound integrity giving it clear advantages over penetrating keratoplasty.…”

Section: Scanning Electronic Microscopy Evaluation Of the Roughness Omentioning

confidence: 99%

Scanning Electronic Microscopy Evaluation of the Roughness of the Stromal Bed After Deep Corneal Cut with the LDV Femtosecond Laser (Z6) (Ziemer) and the ONE Microkeratome (Moria)

Varga

Bergin

Roy³

et al. 2016

Current Eye Research

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Purpose: To compare the stromal bed surface quality and the accuracy of dissection depth after deep lamellar cuts using the Leonardo Da Vinci (LDV) femtosecond laser (Z6) and the ONE Microkeratome. Methods: Deep lamellar cuts were performed on nine human donor corneoscleral buttons: five with the LDV femtosecond (FS) laser (Z6) (Ziemer) and four with the ONE Microkeratome (MK) (Moria). Corneal thickness was measured with ultrasound pachymetry before and after the dissection. The Stromal bed quality was evaluated using light microscopy (n = 4) and scanning electron microscopy (SEM) (n = 9). The surface roughness on SEM images was graded on the scale of 1 (smoothest) to 5 (roughest) by four observers, blinded to the method used. Particle analysis on the SEM images was performed in order to have an objective measure of smoothness. Results: The achieved dissection depth using the FS laser was 496.4 ± 46.4 µm when attempting 500 µm and 474 ± 60 µm with the microkeratome when attempting 350 µm. Histological evaluation of the corneoscleral buttons by both light and electron microscopy showed significantly smoother surface using the FS laser compared to the microkeratome. There were fewer and smaller particles observed in the SEM images of FS laser cut buttons (p < 0.001).The average observer based score of anterior surface roughness (50×) was 2.2 for the FS laser and 3.9 for the microkeratome dissections (p < 0.001). Conclusions: The LDV femtosecond laser (Z6) platform is capable of creating deep corneal lamellar dissection with smoother surface quality and with more predictable cut depth as compared to the One Microkeratome.ARTICLE HISTORY

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Endothelial keratoplasty: DSEK/DSAEK or DMEK - the thinner the better?

Cited by 260 publications

References 80 publications

Characterization of cryopreserved primary human corneal endothelial cells cultured in human serum-supplemented media

Characterization of cryopreserved primary human corneal endothelial cells cultured in human serum-supplemented media

Uveítes: diretrizes terapêuticas

Scanning Electronic Microscopy Evaluation of the Roughness of the Stromal Bed After Deep Corneal Cut with the LDV Femtosecond Laser (Z6) (Ziemer) and the ONE Microkeratome (Moria)

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