Endothelial lesions in the aorta of egg yolk-fed miniature swine: A study by scanning and transmission electron microscopy

Oxygen free radicals as a mechanism of hypercholesterolemic atherosclerosis: Effects of probucol

“…Endothelial cell injury has been theorized to be the basic mechanism for initiation and maintenance of atherosclerosis [57,58]. Hypercholesterolemia-induced atherosclerosis may be due to endothelial cell injury which is known to be produced by cholesterol [39,78]. However, the mechanism of cholesterol-induced endothelial cell injury is not clear.…”

Aortic endothelium of alloxan diabetic rabbits: A quantitative study using scanning electron microscopy

“…We have used scanning electron microscopy for quantitative analysis of the main types of endothelial injury in experimental diabetes; using this method, large areas of endothelial luminal surface can be observed for the presence of micro-damage. The criteria for early endothelial injury are 1) number and size of zones of de-endothelialization, 2) presence of argyrophilic cells, 3) craters and openings on the cell surface and at intercellular junctions and 4) changes in the cell size [9][10][11][12].…”