Endothelial mechanosensors of shear stress as regulators of atherogenesis

Zaragoza, Carlos; Marquez, Susana; Saura, Marta

doi:10.1097/mol.0b013e328357e837

Cited by 52 publications

(36 citation statements)

References 63 publications

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“…Endothelial cells are equipped with a variety of factors to detect mechanical stimuli (Ando and Yamamoto 2013;Zaragoza et al 2012;Chatzizisis et al 2007). The long protruding primary cilium (Egorova et al 2012), glycocalyx, G-protein coupled receptors (GPCRs) (Chachisvilis et al 2006), ion channels (Ranade et al 2014), receptor tyrosine kinases (RTKs), and caveolae are present at the cell's apical surface in contact with the bloodstream.…”

Section: Mechanosensitive Systems Of Endothelial Cellsmentioning

confidence: 99%

Innovation of Vascular Engineering by Mechanomedicine

Takahashi

Naruse

2016

Vascular Engineering

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This article describes how physical forces contribute to development, physiology, and pathology of vascular cells, focusing on endothelial cells and vascular smooth muscle cells. Based on these basic understandings of the mechanobiology, we discuss mechanomedicine, an application of the mechanobiology to medicine. Basic knowledge about cellular responses, such as cellular signal transduction pathway, gene expression, and cytoskeletal remodeling, to mechanical stimuli is important for understanding the pathology of vascular diseases including atherosclerosis. Introducing the knowledge of the vascular mechanobiology will not only contribute to the development of regenerative medicine using pluripotent stem cells but also provide a way to prevent diseases caused by thromboembolisms, such as myocardial and cerebral infarctions. IntroductionMankind has made remarkable advances in machine technology, which have enabled the realization of the creation of not only devices that act on the external world but also artificial organs that complement or replace the diminished functions of organs in our bodies. Functions of machine technology-derived organs (e.g.,

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Section: Mechanosensitive Systems Of Endothelial Cellsmentioning

confidence: 99%

Innovation of Vascular Engineering by Mechanomedicine

Takahashi

Naruse

2016

Vascular Engineering

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“…Transport into the local tissue bed requires permeability of the endothelium, cell membrane and other vascular barriers (Komarova and Malik 2010;Zaragoza et al 2012). When administered systemically, only a small fraction of the injected drug ever reaches the target tissue, with the rest circulating through the healthy tissue, resulting in dose-limiting toxic side effects (Hanahan and Weinberg 2011).…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Ultrasound Promotes Clathrin-Dependent Endocytosis for Drug Penetration into Tumor Cells

Tardoski

Gineyts

Ngo

et al. 2015

Ultrasound in Medicine & Biology

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“…The geometric distribution of mechanical stress is closely associated with site-specific susceptibility to pathological changes [1,2,18,103], such as atherosclerosis and inflamma-tion in arteries, suggesting the effects of mechanical stress on the phenotypic changes of ECs and vascular wall. Clinical studies suggested that the sites of atherosclerosis are not random, but preferentially located at arterial branches and curvatures where the local flow is disturbed.…”

Section: The Interaction Between Mechanosensors and Mechanical Stressmentioning

confidence: 99%

Endothelial mechanosensors: the gatekeepers of vascular homeostasis and adaptation under mechanical stress

Deng

Huo

Luo

2014

Sci. China Life Sci.

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Endothelial cells (ECs) not only serve as a barrier between blood and extravascular space to modulate the exchange of fluid, macromolecules and cells, but also play a critical role in regulation of vascular homeostasis and adaptation under mechanical stimulus via intrinsic mechanotransduction. Recently, with the dissection of microdomains responsible for cellular responsiveness to mechanical stimulus, a lot of mechanosensing molecules (mechanosensors) and pathways have been identified in ECs. In addition, there is growing evidence that endothelial mechanosensors not only serve as key vascular gatekeepers, but also contribute to the pathogenesis of various vascular disorders. This review focuses on recent findings in endothelial mechanosensors in subcellular microdomains and their roles in regulation of physiological and pathological functions under mechanical stress.

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Endothelial mechanosensors of shear stress as regulators of atherogenesis

Abstract: The discovery of a connection between endothelial cell structures such as cilia, integrin, extracellular matrix, and signaling events opens today a new chapter in our understanding of the molecular mechanisms regulating vascular responses to the changes in flow.

Cited by 52 publications

References 63 publications

Innovation of Vascular Engineering by Mechanomedicine

Innovation of Vascular Engineering by Mechanomedicine

Low-Intensity Ultrasound Promotes Clathrin-Dependent Endocytosis for Drug Penetration into Tumor Cells

Endothelial mechanosensors: the gatekeepers of vascular homeostasis and adaptation under mechanical stress

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