Endothelial Nitric Oxide Synthase Gene Polymorphism in the Indian and Mestizo Populations of Mexico

Rosas-Vargas, Haydeé; Flores-Segura, Adrían; Guizada-Claure, Boris; Vargas‐Alarcón, Gilberto; Granados, Julio; Salamanca, F; Coral-Vázquez, Ramón Mauricio

doi:10.1353/hub.2003.0027

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…There is only one previous study reporting the frequencies of eNOS polymorphisms in the Mexican Amerindians Huastec, Mayan, and Mayo (Rosas-Vargas et al, 2003), which showed that the Asp298 allele frequency in the Huastec (11.5%) is significantly higher ( p < 0.01) than the 5.0% fre-quency we found in the Amerindians studied here. This difference between Brazilian and Mexican Amerindians could be attributed to European admixture in the Huastec group (Rosas-Vargas et al, 2003). However, despite the scarcity of data, these findings suggest similar allele frequencies for North and South Amerindians.…”

Section: T -786 C Glu298aspcontrasting

confidence: 82%

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

Luizon

Izidoro-Toledo²,

Simões³

et al. 2009

DNA and Cell Biology

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Interethnic disparities in the distribution of endothelial nitric oxide synthase (eNOS) polymorphisms may affect nitric oxide (NO)-mediated effects of and responses to drugs. While there are differences between black and white subjects there is no information regarding the distribution of eNOS gene alleles and haplotypes in Amerindians. We studied three clinically relevant eNOS polymorphisms (T(-786)C in the promoter, a variable number of tandem repeats in intron 4, and the Glu298Asp in exon 7) and eNOS haplotypes in 170 Amerindians from three tribes of the Brazilian Amazon. The results were compared with previous findings for black and white Brazilians. The Asp298, C(-786), and 4a alleles were much less common in Amerindians (5.0%, 3.2%, and 4.1%, respectively) than in blacks (15.1%, 19.5%, and 32.0%, respectively) or whites (32.8%, 41.9%, and 17.9%, respectively) (p < 0.001). The haplotype including the most common alleles for each polymorphism was much more common in Amerindians (89%) than in blacks (45%) or whites (41%). Our findings are consistent with a lower genetic diversity in Amerindians compared with blacks and whites. These striking differences may be of major relevance for case-control association studies focusing on eNOS gene polymorphisms and may explain, at least in part, differences in the responses to cardiovascular drugs.

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Section: T -786 C Glu298aspcontrasting

confidence: 82%

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

Luizon

Izidoro-Toledo²,

Simões³

et al. 2009

DNA and Cell Biology

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“…Contradictory results have been obtained in other studies on a possible correlation between the eNOS Glu298Asp polymorphism and heart disease (Hibi et al, 1998;Miyamoto et al, 1998;Kato et al, 1999;Nassar et al, 2001;Colombo et al, 2003;Shaw et al, 2005;van Beynum et al, 2008;Velloso et al, 2010;Gamil et al, 2017;Khatami et al, 2017;Shahid and Rehman, 2017). This may depend on group selection, due to variable distribution of the polymorphism in different ethnic groups, and small sample size (Chen et al, 2001;Rosas-Vargas et al, 2003;Sandrim et al, 2006). The Glu allele has been reported to have different allelic frequencies: 74% in the USA (Fatini et al, 2004), 99% in Japan (Kato et al, 1999), 99% in Korea (Park et al, 2004), 88% in Mexico (Stephens et al, 1996), 85% in Chile (Jaramillo et al, 2006), 83% in Turkey (Cam et al, 2005) and 67% in Brazil (Velloso et al, 2010).…”

Section: Discussionmentioning

confidence: 87%

Research Article Glu298Asp polymorphism in the <i>NOS3</i> gene is not associated with susceptibility to chronic heart failure in a Russian population

Goppe¹,

Maltese²,

Чернова³

et al. 2019

Genet. Mol. Res.

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The eNOS Glu298Asp (rs1799983) polymorphism of the NOS3 gene has been implicated as a risk factor for cardiovascular diseases; however, not all studies find significant associations. We examined this possibility in a Russian (Siberian) population. One hundred patients with chronic heart failure and 40 controls were investigated. PCR analysis was performed on DNA samples. The aim was to evaluate a possible association between the (Glu298Asp) polymorphism (rs1799983) of the NOS3 gene and susceptibility to chronic heart failure in the Russian population. We evaluated genotype distributions in patient and control groups and assessed the relationship between genotypes and chronic heart failure. We found that this polymorphism is not associated with increased risk of chronic heart failure in our study cohort. In conclusion, testing of the NOS3 gene polymorphism does not seem useful for evaluating predisposition for chronic heart failure or its diagnosis and prognosis.

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“…26 The frequency of the endothelial cell nitric oxide synthase (eNOS) 894 G/T polymorphism that is associated with ED is similar among the healthy Mexican Mestizo, Huastec, Mayo and Mayan subpopulations, but differs from that of Caucasians. 27 In Mexican Mestizo men, the 894 G/T polymorphism was identified as an independent risk factor for ED along with hypertension and diabetes mellitus. 28 Although no study of sildenafil response in relationship to the 894 polymorphism is available in a Mexican population, the sildenafil response was decreased in German ED patients heterozygous for Relationship satisfaction in men with ED E Zonana Farca et al the 894 T polymorphism, with a gene dosage effect evident in homozygous patients.…”

Section: Discussionmentioning

confidence: 99%

Self-esteem, confidence and relationship satisfaction in men with erectile dysfunction: a randomized, parallel-group, double-blind, placebo-controlled study of sildenafil in Mexico

et al. 2008

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Erectile dysfunction (ED) negatively impacts self-esteem and relationship satisfaction. The Self-Esteem and Relationship (SEAR) questionnaire is a validated, ED-specific, patient-reported instrument that specifically addresses self-esteem and relationship issues within the context of ED. Effective ED treatment with sildenafil in a double-blind, placebo-controlled clinical trial conducted in Brazil, Mexico, Australia and Japan showed pooled cross-cultural improvements in self-esteem, confidence and relationship satisfaction. This report focuses on the results from the subgroup of men from nine Mexican centers who participated in the multinational study. A total of 95 men aged X18 years with clinically diagnosed ED and currently in a stable relationship were randomized to placebo (n ¼ 47) or sildenafil (n ¼ 48). The SEAR results for Mexican men showed that sildenafil treatment led to significant improvements in self-esteem, confidence and relationship satisfaction. These data support an earlier study showing that Latin American men taking sildenafil have similar safety and efficacy profiles compared to non-Latin counterparts.

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Endothelial Nitric Oxide Synthase Gene Polymorphism in the Indian and Mestizo Populations of Mexico

Cited by 16 publications

References 13 publications

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

Research Article Glu298Asp polymorphism in the <i>NOS3</i> gene is not associated with susceptibility to chronic heart failure in a Russian population

Self-esteem, confidence and relationship satisfaction in men with erectile dysfunction: a randomized, parallel-group, double-blind, placebo-controlled study of sildenafil in Mexico

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