Endothelial Progenitor Cells in Autoimmune Disorders

Feugray, Guillaume; Miranda, Sébastien; Le Cam Duchez, Véronique; Bellien, Jérémy; Billoir, Paul

doi:10.1007/s12015-023-10617-y

Cited by 2 publications

(2 citation statements)

References 104 publications

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“…EPCs are the precursor cells of VECs. The main functions of EPCs include inhibiting the inflammatory response of the vascular wall, reducing intimal hyperplasia to promote the repair of the injured endothelium, and preventing the narrowing of blood vessels 58 . EPCs play an important role in ischaemic tissue.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Cai,

Li,

Gao

et al. 2024

Sci Rep

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Ischaemic bowel disease (ICBD) is a group of intestinal ischaemia syndromes caused by various aetiologies of reduced intestinal blood flow or vascular occlusion. ICBD can present as abdominal pain, bloody stool, and diarrhoea. This disease often occurs in middle-aged and elderly individuals with cardiovascular and cerebrovascular diseases. The incidence of ischaemic bowel disease has been increasing for decades, and it is difficult to diagnose, resulting in rapid disease progression and a high mortality rate. Therefore, fully understanding this disease, improving the diagnosis rate of this disease, and finding appropriate treatment methods are urgently needed to improve the condition and prognosis of patients. Umbilical cord blood stem cells are accessible, have weak immunogenicity, and have various biological functions, such as angiogenesis, inflammation and immune regulation. Many studies have confirmed that cord blood stem cells can relieve ischaemia, and these cells have attracted tremendous amounts of attention in regenerative medicine in recent years. In this paper, we discuss the clinical characteristics of ICBD, analyse the characteristics of human umbilical cord blood mononuclear cells (HUCB-MNCs), and use its to treat ischaemic bowel disease. Additionally, we compare the clinical manifestations and related indicators before and after treatment to evaluate the efficacy and safety of these methods.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Cai,

Li,

Gao

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The differentiation of vascular EPCs into mature endothelial cells is involved in repairing damaged endothelium. Evidence has shown that the downregulation of the quantity and function of EPCs is believed to be closely related to the occurrence of various cardiovascular diseases [ [178] , [179] , [180] , [181] ].…”

Section: The Mechanism Of Tongxinluo In Preventing and Treating Cardi...mentioning

confidence: 99%

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

Xin,

Wang,

Hou

et al. 2024

Heliyon

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Endothelial Progenitor Cells in Autoimmune Disorders

Cited by 2 publications

References 104 publications

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

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