Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

Kiewisz, Jolanta; Kaczmarek, Monika M.; Pawłowska, Anna; Kmieć, Zbigniew; Stompór, Tomasz

doi:10.18388/abp.2016_1284

Cited by 25 publications

(21 citation statements)

References 72 publications

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“…Moreover, the SDF-1/CXCR4 axis acts as a key regulator of angiogenesis and contributes to the regulation of endothelial progenitor cell (EPC) recruitment in ischemic tissues. EPCs represent a small population of blood cells that can differentiate into endothelial cells and participate in postnatal angiogenesis [47]. In addition, EPCs are involved in physiological and pathological angiogenesis/vasculogenesis [48].…”

Section: Discussionmentioning

confidence: 99%

Altered microRNA profile during fracture healing in rats with diabetes

et al. 2020

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Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications. We hypothesized that the functions of certain miRNAs and the changes in their patterns of expression may contribute to the pathogenesis of impaired fractures due to DM. Methods: In this study, 108 male Sprague-Dawley rats were divided into DM and control groups. DM rats were created by a single intravenous injection of streptozotocin. Closed transverse femoral shaft fractures were created in both groups. On post-fracture days 5, 7, 11, 14, 21, and 28, miRNA was extracted from the newly generated tissue at the fracture site. Microarray analysis was conducted with miRNA samples from each group on post-fracture days 5 and 11. The microarray findings were validated by real-time polymerase chain reaction (PCR) analysis at each time point. Results: Microarray analysis revealed that, on days 5 and 11, 368 and 207 miRNAs, respectively, were upregulated in the DM group, compared with the control group. The top four miRNAs on day 5 were miR-339-3p, miR451-5p, miR-532-5p, and miR-551b-3p. The top four miRNAs on day 11 were miR-221-3p, miR376a-3p, miR-379-3p, and miR-379-5p. Among these miRNAs, miR-221-3p, miR-339-3p, miR-376a-3p, miR-379-5p, and miR-451-5p were validated by real-time PCR analysis. Furthermore, PCR analysis revealed that these five miRNAs were differentially expressed with dynamic expression patterns during fracture healing in the DM group, compared with the control group. Conclusions: Our findings will aid in understanding the pathology of impaired fracture healing in DM and may support the development of molecular therapies using miRNAs for the treatment of impaired fracture healing in patients with DM.

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Section: Discussionmentioning

confidence: 99%

Altered microRNA profile during fracture healing in rats with diabetes

et al. 2020

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“…When the endothelium is damaged, the connection between EPCs and stromal cells is weakened due to the influence of some inflammatory cytokines and mobilization factors, such as tumor necrosis factor-a, interleukin-6, and vascular endothelial growth factor, stimulating EPCs mobilization and release from bone marrow to peripheral circulation (Patel et al, 2016). After EPCs enter the peripheral blood, they migrate and adhere to the damaged blood vessels, proliferate and differentiate into mature endothelial cells, promote reendothelialization and neovascularization, so as to maintain the integrity of endothelial structure and repair ischemic tissue (Minhajat et al, 2015;Kiewisz et al, 2016). However, it has been shown that Ang II impairs the proliferative and migratory ability of EPCs, resulting in diminished vascular regeneration (Endtmann et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial progenitor cells (EPCs) are the precursor cells of endothelial cells, which mainly exist in bone marrow, cord blood, and peripheral blood (Murohara et al, 2000). EPCs are quite capable of repairing damaged vascular endothelium and regenerating blood vessel (Altabas et al, 2016;Kiewisz et al, 2016). Therefore, EPCs have a broad prospect in the research and treatment of cardiovascular and cerebrovascular diseases, diabetes, peripheral vascular diseases, and other vascular injury diseases.…”

Section: Introductionmentioning

confidence: 99%

Rhynchophylline Attenuates Senescence of Endothelial Progenitor Cells by Enhancing Autophagy

Lin

Zhang

et al. 2020

Front. Pharmacol.

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The increase of blood pressure accelerates endothelial progenitor cells (EPCs) senescence, hence a significant reduction in the number of EPCs is common in patients with hypertension. Autophagy is a defense and stress regulation mechanism to assist cell homeostasis and organelle renewal. A growing number of studies have found that autophagy has a positive role in repairing vascular injury, but the potential mechanism between autophagy and senescence of EPCs induced by hypertension has rarely been studied. Therefore, in this study, we aim to explore the relationship between senescence and autophagy, and investigate the protective effect of rhynchophylline (Rhy) on EPCs. In angiotensin II (Ang II)treated EPCs, enhancing autophagy through rapamycin mitigated Ang II-induced cell senescence, on the contrary, 3-methyladenine aggravated the senescence by weakening autophagy. Similarly, Rhy attenuated senescence and improved cellular function by rescuing the impaired autophagy in Ang II-treated EPCs. Furthermore, we found that Rhy promoted autophagy by activating AMP-activated protein kinase (AMPK) signaling pathway. Our results show that enhanced autophagy attenuates EPCs senescence and Rhy rescues autophagy impairment to protect EPCs against Ang II injury.

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“…Endothelial progenitor cells (EPCs) are also involved in the physiological and pathological progression of new vessel formation (Kiewisz, Kaczmarek, Pawlowska, Kmiec, & Stompor, 2016;Patel, Donovan, & Khosrotehrani, 2016). EPCs contain cell surface markers CD133, CD34 and vascular endothelial growth factor receptor-2 (VEGFR2), which facilitate postnatal vasculogenesis (Asahara et al, 1999) and exert regenerative effects.…”

Section: Introductionmentioning

confidence: 99%