Endothelial progenitor cells: what use for the cardiologist?

Siddique, Aurangzeb; Shantsila, Eduard; Lip, Gregory Y.H.; Varma, Chetan

doi:10.1186/2040-2384-2-6

Cited by 35 publications

(42 citation statements)

References 120 publications

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“…However, other studies provided evidence to support the development of mature ECs from the homing of endothelial progenitor cells (EPCs) within the blood [7,8]. In the past decades, intensive effort has been undertaken to understand the biological properties of EPCs and their relevant contribution towards endothelial repair, but the results are still conflicting [9,10]. Some recent reports suggest that EPC may not contribute directly to regrowth of the endothelium during the vascular healing process [9] and perhaps, the only valid & 2014 The Author(s) Published by the Royal Society.…”

Section: Introductionmentioning

confidence: 99%

Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling

Tahir

Bona-Casas

Narracott

et al. 2014

J. R. Soc. Interface.

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Re-establishing a functional endothelium following endovascular treatment is an important factor in arresting neointimal proliferation. In this study, both histology (in vivo) and computational simulations (in silico) are used to evaluate neointimal growth patterns within coronary arteries along the axial direction of the stent. Comparison of the growth configurations in vivo and in silico was undertaken to identify candidate mechanisms for endothelial repair. Stent, lumen and neointimal areas were measured from histological sections obtained from eight right coronary stented porcine arteries. Two reendothelialization scenarios (endothelial cell (EC) random seeding and EC growth from proximal and distal ends) were implemented in silico to evaluate their influence on the morphology of the simulated lesions. Subject to the assumptions made in the current simulations, comparison between in vivo and in silico results suggests that endothelial growth does not occur from the proximal and distal ends alone, but is more consistent with the assumption of a random seeding process. This may occur either from the patches of endothelium which survive following stent implantation or from attachment of circulating endothelial progenitor cells.

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Section: Introductionmentioning

confidence: 99%

Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling

Tahir

Bona-Casas

Narracott

et al. 2014

J. R. Soc. Interface.

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“…Increased number of endothelial progenitor cells after exercise is probably caused by acute mobilization process of endothelial progenitor cells contained in bone marrow or due to shear stress that induces the release of endothelial progenitor cells into circulation. 8,9 Given the important role of exercise for cardiovascular health, in 2007 the American College of Sports Medicine (ACSM) and the American Heart Association (AHA) recommend that all healthy adults need to do moderateintensity aerobic exercise for a minimum of 30 minutes (or can be accumulated toward the 30 minutes minimum by performing bouts each lasting 10 minutes) five days per week.…”

Section: Conclusion: the Percentage Of Circulating Cd31mentioning

confidence: 99%

The effect of moderate-intensity acute aerobic exercise duration on the percentage of circulating CD31<sup>+</sup> cells in lymphocyte population

2016

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“…Accordingly, misleading conclusions extracted from a huge number of studies (about 1,800 listed in the PubMed database, according to an estimation by Pober [198]), await reinterpretation. These studies predominantly associated alterations and/or reduction of the circulating pool of ‘endothelial progenitor cells' with multiple manifestations of cardiovascular disorders [199]. This is why the extent of this pool has been considered a mirror of vascular health or a surrogate biomarker of cardiovascular risk and of the ongoing vascular damage [194]; however, current knowledge and recent methodological advances allow the analysis and discrimination of genuine vascular precursor cells with more homogeneous, clonogenic, proliferative and vasculogenic abilities in vivo.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The Challenges for Cardiac Vascular Precursor Cell Therapy: Lessons from a Very Elusive Precursor

2013

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There is compelling evidence that cardiovascular disorders arise and/or progress due mainly to endothelial dysfunction. Novel therapeutic strategies aim to generate new myocardial tissue using cells with regenerative potential, either alone or in combination with biomaterials, cytokines and advanced monitoring devices. Among the human adult progenitor cells used in such methods, those historically termed ‘endothelial progenitor cells' show promise for vascular growth and repair. Asahara et al. [Science 1997;275:964-967] initially described putative endothelial cell precursors in 1997. Subsequently, distinct cell populations termed endothelial colony-forming units-Hill, circulating angiogenic cells and endothelial colony-forming cells were identified that varied in terms of phenotype, vascular homeostasis contribution and purity. Notably, most of these cells are not genuine vascular precursor cells belonging to the endothelial lineage. This review provides a broad overview of the main properties of the endothelium, focusing on the basis governing its growth and repair. We discuss efforts to identify true vascular precursors, a matter of debate for the past 15 years, as well as recent methodological advances in identifying new hierarchies of more homogeneous, clonogenic and proliferative vascular endothelial-lineage precursors. Consideration of these issues provides insights that may help develop more effective therapies against human diseases that involve vascular deficits.

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Endothelial progenitor cells: what use for the cardiologist?

Cited by 35 publications

References 120 publications

Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling

Endothelial repair process and its relevance to longitudinal neointimal tissue patterns: comparing histology with in silico modelling

The effect of moderate-intensity acute aerobic exercise duration on the percentage of circulating CD31<sup>+</sup> cells in lymphocyte population

The Challenges for Cardiac Vascular Precursor Cell Therapy: Lessons from a Very Elusive Precursor

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